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N-((4-(2-cyanophenyl)-1-piperazinyl)methyl)-3-methylbenzamide (CID 3645619) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(237)
 
 
Inconclusive(31)
 
 
Unspecified(20)
 
 
Top Targets:
p450(18)
 
 
 
 
7TM GPCR Srsx(9)
 
 
 
 
HSD10-like SD..(8)
 
 
7TM GPCR Srx(8)
 
 
 
 
FAM101(8)
 
 
 
BioAssay Types:
Confirmatory(249)
 
 
 
 
Literature(43)
 
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(205)
 
 
 
Ki(19)
 
 
 
EC50(4)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 214    Data Row: 313   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103226857]
EC50 0.0083Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274437, Type: Literature]D(4) dopamine receptor [gi:1345939]
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2
[SID103226857]
EC50 0.0083Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay [AID268991, Type: Literature]D(4) dopamine receptor [gi:1345939]
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3
[SID103226857]
Ki 0.0087Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand [AID63520, Type: Literature]
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4
[SID103226857]
Ki 0.00871Binding affinity of compound towards human dopamine receptor D4 was determined [AID243277, Type: Literature]D(4) dopamine receptor [gi:1345939]
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5
[SID103226857]
Ki 0.009Binding affinity towards cloned human Dopamine receptor D4 [AID63530, Type: Literature]
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6
[SID103226857]
Ki 0.01698Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]thymidine as radioligand [AID243285, Type: Literature]D(4) dopamine receptor [gi:1345939]
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7
[SID103226857]
EC50 0.017Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand [AID65922, Type: Literature]
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8
[SID103226857]
Ki 0.025Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity) [AID62486, Type: Literature]D(2) dopamine receptor [gi:118205]
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9
[SID103226857]
Ki 0.025Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retina [AID63853, Type: Literature]
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10
[SID103226857]
Ki 0.168Binding affinity at alpha-1 adrenergic receptor [AID36324, Type: Literature]
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11
[SID103226857]
Ki 0.177Binding affinity at Alpha-2 adrenergic receptor [AID35784, Type: Literature]
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12
[SID103226857]
Ki 0.385Binding affinity at 5-hydroxytryptamine 1A receptor [AID4469, Type: Literature]
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13
[SID103226857]
Ki 2.81Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand [AID64981, Type: Literature]
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14
[SID103226857]
Ki 2.81838Binding affinity towards human dopamine receptor D2 was determined by using [3H]spiperone as radioligand [AID243284, Type: Literature]D(2) dopamine receptor [gi:118206]
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15
[SID103226857]
Ki 3.71535Binding affinity towards dopamine receptor D2 was determined by using [3H]spiperone as radioligand [AID243283, Type: Literature]
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16
[SID103226857]
Ki 3.74Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand [AID62925, Type: Literature]
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17
[SID103226857]
Ki 3.74Binding affinity towards cloned human Dopamine receptor D2 [AID63054, Type: Literature]
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18
[SID103226857]
Ki 4.01Binding affinity at 5-hydroxytryptamine 2A receptor [AID5369, Type: Literature]
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19
[SID103226857]
Ki 6.3Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (low-affinity) [AID62487, Type: Literature]D(2) dopamine receptor [gi:118205]
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20
[SID103226857]
Ki 18.3Binding affinity for dopamine D2-D3 like receptor labelled with [3H]YM-09151-2 in striatum [AID64302, Type: Literature]
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