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6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline (CID 3644637) - Compound BioActivity Data
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BioActivity Outcomes:
Active(17)
 
 
Inactive(46)
 
 
Inconclusive(17)
 
 
Unspecified(33)
 
 
Top Targets:
7tm 4(21)
 
 
 
 
p450(10)
 
 
PIKKc TOR(4)
 
 
 
Pyr redox dim(4)
 
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(66)
 
 
 
 
Literature(46)
 
 
 
 
BioActivity Types:
Potency(67)
 
 
 
 
IC50(10)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 102    Data Row: 113   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176822]
Ki 0.001Binding affinity for human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]mesulergine [AID254608, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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2
[SID103176822]
Ki 0.1Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT [AID254604, Type: Literature]5-hydroxytryptamine receptor 2B [gi:1168220]
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3
[SID103176822]
Ki 0.15849Binding affinity for human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]ketanserin [AID254606, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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4
[SID90341546]
Potency 7.3078Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory] [geneid:4780]
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5
[SID90341546]
Potency 7.3078Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID90341546]
Potency 11.5774qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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7
[SID90341546]
Potency 14.1254HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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8
[SID90341546]
Potency 17.7828qHTS for Inhibitors of ATXN expression: Validation [AID588378, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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9
[SID90341546]
Potency 44.6684Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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10
[SID90341546]
Potency 44.6684qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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11
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2B [AID624218, Type: Literature]5-hydroxytryptamine receptor 2B [Homo sapiens] [gi:222080049]
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12
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2B [AID624218, Type: Literature]5-hydroxytryptamine receptor 2B [Homo sapiens] [gi:222080049]
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13
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2A [AID624223, Type: Literature]5-hydroxytryptamine receptor 2A isoform 2 [Homo sapiens] [gi:260099679]
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14
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2A [AID624223, Type: Literature]5-hydroxytryptamine receptor 2A isoform 2 [Homo sapiens] [gi:260099679]
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15
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2C [AID624209, Type: Literature]5-hydroxytryptamine receptor 2C isoform b precursor [Homo sapiens] [gi:377520139]
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16
[SID135650998]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2C [AID624209, Type: Literature]5-hydroxytryptamine receptor 2C isoform b precursor [Homo sapiens] [gi:377520139]
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17
[SID85209288]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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18
[SID103176822]
Ki 0.001GRAC: human 5-HT2C selective antagonist [AID540509, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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19
[SID103176822]
IC50 100Inhibition of heterologously expressed human cytochrome P450 1A2 [AID54209, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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20
[SID103176822]
IC50 100Inhibition of heterologously expressed human Cytochrome P450 1A2 at 500 uM [AID54223, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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