Hydralazine (CID 3637) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(37)
 
 
Inactive(231)
 
 
Inconclusive(68)
 
 
Unspecified(277)
 
 
Top Targets:
p450(34)
 
 
 
 
 
7TM GPCR Srx(16)
 
 
 
7TM GPCR Srsx(11)
 
 
 
PLN02808(5)
 
 
NR LBD GR(5)
 
 
 
BioAssay Types:
Confirmatory(221)
 
 
 
 
Literature(218)
 
 
 
 
 
Screening(13)
 
 
BioActivity Types:
Potency(177)
 
 
 
 
IC50(117)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 476    Data Row: 613   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11111261]
Potency 0.0398qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway [AID917, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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2
[SID11111262]
Potency 0.0775Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID90341825]
Potency 0.8196Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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4
[SID90341825]
Potency 2.3109qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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5
[SID90341825]
Potency 2.5929qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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6
[SID103171825]
IC50 3.649DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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7
[SID11111262]
Potency 3.9811qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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8
[SID11111262]
Potency 3.9811qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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9
[SID11111262]
Potency 3.9811qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID11111262]
Potency 5.0119qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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11
[SID90341825]
Potency 7.9433qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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12
[SID11111261]
Potency 7.9433qHTS Assay for Inhibitors of Human Muscle Pyruvate Kinase [AID958, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286420]
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13
[SID11111261]
Potency 7.9433qHTS Assay for Inhibitors of Human Muscle Pyruvate Kinase [AID958, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286420]
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14
[SID11111261]
Potency 7.9433qHTS Assay for Inhibitors of Human Muscle Pyruvate Kinase [AID958, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286420]
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15
[SID11111262]
Potency 12.5594qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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16
[SID11111261]
Potency 12.5893qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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17
[SID11111262]
Potency 74.5Gel-Based Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID2707, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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18
[SID103171825]
 Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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19
[SID103171825]
 Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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20
[SID103171825]
 Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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21
[SID11111261]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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22
[SID11111261]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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23
[SID11111261]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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24
[SID11111262]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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25
[SID11111262]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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26
[SID11111262]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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27
[SID11111262]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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28
[SID11111262]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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29
[SID103171825]
 Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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30
[SID103171825]
 Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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31
[SID103171825]
 Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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32
[SID103171825]
 Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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33
[SID103171825]
 Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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34
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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35
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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36
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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37
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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38
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
View
39
[SID103171825]
 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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40
[SID103171825]
 Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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41
[SID103171825]
 Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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42
[SID103171825]
 Inhibition of 4-hydroxynonenal-induced carbonyl stress in HMEC1 cells assessed as prevention of increase in carbonylated protein level at 100 uM relative to control [AID408066, Type: Literature]
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43
[SID48416088]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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44
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_21, Type: Literature]
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45
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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46
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_39, Type: Literature]
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47
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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48
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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49
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_55, Type: Literature]
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50
[SID11111262]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
View