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Hycanthone (CID 3634) - Compound BioActivity Data
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BioActivity Outcomes:
Active(169)
 
 
Inactive(952)
 
 
Inconclusive(118)
 
 
Unspecified(66)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(22)
 
 
 
p450(19)
 
 
 
 
 
NR LBD PPAR(14)
 
 
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(540)
 
 
 
 
Confirmatory(514)
 
 
 
 
 
Literature(132)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(390)
 
 
 
 
 
IC50(45)
 
 
 
EC50(8)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1033    Data Row: 1305   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204082]
Potency-Replicate_1 0.2371qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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2
[SID144204082]
Potency-Replicate_1 0.2985qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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3
[SID144204082]
Potency 0.335qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID144204082]
Potency-Replicate_1 0.5308qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144204082]
Potency 0.5309qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID56424135]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID103188531]
EC50 0.8In vitro evaluation for intercalating potency by using calf thymus DNA in ethidium bromide displacement assay [AID46155, Type: Literature]
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8
[SID144204082]
Potency-Replicate_1 0.8413qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
9
[SID144204082]
TR Potency (uM) 0.87418qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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10
[SID144204082]
Potency-Replicate_1 1.0591qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
11
[SID56424135]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID144204082]
AhR Potency (uM) 1.18832qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
13
[SID103188531]
IC50 1.5Inhibitory concentration against cytochrome P450 2D6 [AID240619, Type: Literature]
View
14
[SID104171314]
Potency 1.6137S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
View
15
[SID11533028]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
16
[SID103188531]
IC50 3.024Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay [AID576507, Type: Literature]
View
17
[SID11533028]
Potency 3.6964Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
18
[SID104171314]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
19
[SID144204082]
Potency-Replicate_1 4.7308qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
View
20
[SID104171314]
Potency 4.7755Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
21
[SID11112528]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
View
22
[SID11112528]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
View
23
[SID144204082]
Potency-Replicate_1 5.9557qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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24
[SID56424135]
Potency 6.5131Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
25
[SID170466535]
Potency-Replicate_1 6.6819qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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26
[SID144204082]
Potency-Replicate_1 6.6824qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
View
27
[SID56424135]
AC50_uM 6.95Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity [AID651657, Type: confirmatory]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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28
[SID26748752]
Potency 7.9433Counterscreen for APE1 Inhibitors: Fluorescent Dye Displacement Assay [AID2564, Type: confirmatory]
View
29
[SID11112528]
Potency 7.9433qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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30
[SID11533028]
AC50_uM 9.33FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
View
31
[SID11533028]
Potency 10qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (Protease relase) [AID2669, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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32
[SID144204082]
Ratio Potency (uM) 10.2904qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
View
33
[SID104171314]
Potency 11.1749qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
34
[SID104171314]
Potency 11.2117S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
View
35
[SID144204082]
Potency 11.2202qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
36
[SID11112528]
Potency 11.2202qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
37
[SID56424135]
Potency 11.5821qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
38
[SID26748752]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
39
[SID170466535]
Potency-Replicate_1 13.3322qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
View
40
[SID170466535]
Potency-Replicate_1 13.3322qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
View
41
[SID144204082]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
View
42
[SID144204082]
Ratio Potency (uM) 13.4481qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
43
[SID11533028]
Potency 15.8489qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
View
44
[SID26748752]
Potency 15.8489Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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45
[SID56424135]
Potency 16.3601Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
View
46
[SID170466535]
Potency-Replicate_1 18.8322qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
View
47
[SID56424135]
Potency 19.9526qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
48
[SID144204082]
Ratio Potency (uM) 20.1215qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
49
[SID56424135]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
50
[SID144204082]
Potency-Replicate_1 21.3138qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View