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1-(2-chloro-5-nitrophenyl)sulfonyl-N-(6-fluoro-1,3-benzothiazol-2-yl)piperidine-4-carboxamide (CID 3608891) - Compound BioActivity Data
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BioActivity Outcomes:
Active(70)
 
 
Inactive(632)
 
 
Inconclusive(46)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(44)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
ABCC CFTR1(8)
 
 
 
 
BioAssay Types:
Screening(494)
 
 
 
 
 
Confirmatory(233)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(161)
 
 
 
 
 
IC50(50)
 
 
 
 
 
EC50(11)
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 680    Data Row: 754   Total Pages: 38   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22409218]
IC50 2.34HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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2
[SID22409218]
IC50 2.37HTS Counterscreen for Detection of Compound Cytotoxicity in MIN6 Cells [AID2122, Type: confirmatory]
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3
[SID22409218]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID22409218]
Potency 4.1095qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID22409218]
EC50 4.696Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1999, Type: confirmatory]
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6
[SID22409218]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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7
[SID22409218]
Potency 6.7016qHTS Assay for the Inhibitors of L3MBTL1: Hit Validation [AID540279, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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8
[SID22409218]
AC50_uM 7.006ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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9
[SID22409218]
Potency 7.0795Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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10
[SID22409218]
IC50 7.724Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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11
[SID22409218]
AC50_uM 8.244Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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12
[SID22409218]
Potency 8.9125qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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13
[SID22409218]
Potency 9.2qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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14
[SID22409218]
Potency 9.2qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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15
[SID22409218]
Potency 10qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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16
[SID22409218]
Potency 10.691qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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17
[SID22409218]
IC50 10.88High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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18
[SID22409218]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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19
[SID22409218]
CC50 11.97An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) [AID2410, Type: confirmatory]
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20
[SID22409218]
IC50 12.01A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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