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Hexachlorophene (CID 3598) - Compound BioActivity Data
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BioActivity Outcomes:
Active(585)
 
 
Inactive(859)
 
 
Inconclusive(336)
 
 
Unspecified(311)
 
 
Top Targets:
7TM GPCR Srx(43)
 
 
 
 
7TM GPCR Srsx(42)
 
 
 
 
NR LBD PPAR(40)
 
 
 
 
NR LBD ER(34)
 
 
 
 
 
NR LBD AR(26)
 
 
 
 
BioAssay Types:
Confirmatory(871)
 
 
 
 
 
Screening(598)
 
 
 
 
Literature(135)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(635)
 
 
 
 
 
IC50(193)
 
 
 
 
 
EC50(28)
 
 
 
 
AC50(14)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1444    Data Row: 2091   Total Pages: 105   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103171247]
IC50 0.0876DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: confirmatory]Mitogen-activated protein kinase 14 [gi:2499600]
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2
[SID144208548]
Potency-Replicate_1 0.1733qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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3
[SID103171247]
IC50 0.196DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: confirmatory]Mitogen-activated protein kinase 1 [gi:119554]
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4
[SID8139957]
EC50 0.202Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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5
[SID8139957]
EC50 0.244Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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6
[SID8139957]
EC50 0.262Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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7
[SID144213058]
Potency-Replicate_1 0.3438qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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8
[SID144213058]
Ratio Potency (uM) 0.432771qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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9
[SID144208548]
Potency-Replicate_1 0.4841qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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10
[SID103171247]
IC50 0.6389DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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11
[SID103171247]
IC50 0.6443DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: confirmatory]Prostaglandin G/H synthase 2 [gi:3915797]
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12
[SID56422370]
AC50_uM 0.676Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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13
[SID144208548]
Ratio Potency (uM) 0.683804qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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14
[SID103171247]
IC50 0.7486DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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15
[SID56422370]
AC50_uM 0.77HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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16
[SID144208548]
Potency-Replicate_1 0.7743qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID56436644]
AC50_uM 0.84Luminescence Whole-Organism Dose Retest to Confirm Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID463204, Type: confirmatory]
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18
[SID144204650]
Potency-Replicate_1 0.8413qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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19
[SID8139957]
Absolute IC50 0.86Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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20
[SID8139957]
Potency 0.92A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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