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Phloroglucinol (CID 359) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(103)
 
 
Inconclusive(5)
 
 
Unspecified(13)
 
 
Top Targets:
Tyrosinase(4)
 
 
Bromo ALL-1(3)
 
 
Menin(2)
 
 
Geminin(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(87)
 
 
 
 
 
Confirmatory(35)
 
 
 
BioActivity Types:
Potency(32)
 
 
 
IC50(8)
 
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 65    Data Row: 129   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103595115]
Ki 0.00877Inhibition of Crotalus adamanteus venom PLA2 assessed as effect on 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol hydrolysis at 0.15 uM [AID395644, Type: Literature]
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2
[SID103595115]
Ki 0.00886Inhibition of Crotalus adamanteus venom PLA2 assessed as effect on 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol hydrolysis at 0.30 uM [AID395645, Type: Literature]
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3
[SID103595115]
ED50 20.9Antiproliferative activity against human HT1080 cells by MTT assay [AID358853, Type: Literature]
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4
[SID103595115]
ED50 26.4Antiproliferative activity against mouse Colon 26-L5 cells by MTT assay [AID358852, Type: Literature]
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5
[SID103595115]
IC50 36.47Inhibition of human recombinant BACE1 after 60 mins by FRET assay [AID483707, Type: Literature]Beta-secretase 1 [gi:296434407]
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6
[SID103595115]
IC50 Inhibition of sheep COX1 measured by oxygen consumption [AID403716, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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7
[SID103595115]
Inhibition of Crotalus adamanteus venom PLA2-induced edema in Swiss mouse at 50 ug, id [AID395646, Type: Literature]
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8
[SID68348]
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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9
[SID103595115]
IC50 115.2Antioxidant activity assessed as superoxide radical scavenging activity [AID393272, Type: Literature]
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10
[SID103595115]
IC50 128.9Antioxidant activity assessed as APPH generated peroxyl radical scavenging formation by ESR spectrometer [AID393273, Type: Literature]
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11
[SID103595115]
CC50 200Cytotoxicity against african green monkey Vero cells assessed as cell death by MTT assay [AID753302, Type: Literature]
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12
[SID103595115]
IC50 200Inhibition of C-terminal His6-tagged recombinant SARS coronavirus 3C-like protease trans-cleavage activity expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKME as substrate after 60 mins by FRET assay [AID753310, Type: Literature]
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13
[SID103595115]
IC50 392.5Antioxidant activity assessed as Fenton system generated hydroxyl radical scavenging activity by ESR spectrometer [AID393270, Type: Literature]
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14
[SID103595115]
Km 12060Activity of Crotalus adamanteus venom PLA2 assessed as 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol hydrolysis at 0.15 uM [AID395642, Type: Literature]
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15
[SID103595115]
Km 23210Activity of Crotalus adamanteus venom PLA2 assessed as 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol hydrolysis at 0.30 uM [AID395643, Type: Literature]
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16
[SID103595115]
Cytotoxicity against human MRC5 cells at 100 uM after 24 hrs by MTT assay [AID393274, Type: Literature]
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17
[SID103595115]
Inactivation of tyrosinase (unknown origin) assessed as decay half-life using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry [AID733599, Type: Literature]Tyrosinase [gi:401235]
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18
[SID103595115]
Inactivation of tyrosinase (unknown origin) assessed as total oxygen uptake using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry [AID733601, Type: Literature]Tyrosinase [gi:401235]
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19
[SID103595115]
Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization at absorbance 400 nm using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry [AID733603, Type: Literature]Tyrosinase [gi:401235]
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20
[SID103595115]
Inactivation of tyrosinase (unknown origin) assessed as initial rate of oxygen utilization using 4-methylcatechol substrate at 850 uM equimolar concentrations resorcinol by spectrophotometry [AID733605, Type: Literature]Tyrosinase [gi:401235]
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