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Haloperidol (CID 3559) - Compound BioActivity Data
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BioActivity Outcomes:
Active(857)
 
 
Inactive(1553)
 
 
Inconclusive(197)
 
 
Unspecified(2331)
 
 
Top Targets:
7TM GPCR Srsx(227)
 
 
 
 
 
7TM GPCR Srx(152)
 
 
 
 
 
ERG2 Sigma1R(57)
 
 
 
p450(35)
 
 
 
 
 
NR LBD PPAR(27)
 
 
 
 
BioAssay Types:
Literature(1620)
 
 
 
 
 
Confirmatory(917)
 
 
 
 
 
Screening(660)
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(746)
 
 
 
 
 
Ki(490)
 
 
 
 
IC50(378)
 
 
 
 
 
EC50(20)
 
 
 
 
 
Kd(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 4184    Data Row: 4938   Total Pages: 99   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167216]
IC50 7.5e-05In vivo binding affinity against dopamine (D2) receptor in rat caudate-putamen tissue using [3H]nemonapride as radioligand [AID64435, Type: Literature]
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2
[SID103167216]
Ki 0.0001Ratio of Ki for human dopamine D2 receptor to Ki for human dopamine D4 receptor [AID392767, Type: Literature]
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3
[SID103167216]
Ki 0.00012Binding affinity towards human Dopamine receptor D2 using [3H]spiroperidol as radioligand [AID63061, Type: Literature]
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4
[SID103167216]
Ki 0.00016Displacement of [3H]quinpirole from Dopamine receptor D2 [AID63075, Type: Literature]
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5
[SID103167216]
Ki 0.00016Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in LtK cells [AID61612, Type: Literature]D(2) dopamine receptor [gi:118206]
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6
[SID103167216]
Ki 0.0002Binding towards Dopamine receptor D2 using [3H]spiperone from rat striatal membrane [AID65560, Type: Literature]D(2) dopamine receptor [gi:47117674]
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7
[SID103167216]
Ki 0.0002Affinity for Dopamine receptor D2 [AID65243, Type: Literature]D(2) dopamine receptor [gi:47117674]
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8
[SID103167216]
Ki 0.0002Binding affinity was determined against Dopamine receptor D2 using [3H]spiperone [AID65247, Type: Literature]
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9
[SID103167216]
Ki 0.0002Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239347, Type: Literature]
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10
[SID103167216]
Ki 0.0002Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum [AID65908, Type: Literature]
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11
[SID103167216]
IC50 0.00028Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate [AID63028, Type: Literature]D(2) dopamine receptor [gi:47117674]
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12
[SID103167216]
IC50 0.00028Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate [AID63028, Type: Literature]D(3) dopamine receptor [gi:118211]
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13
[SID103167216]
IC50 0.00028Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate [AID63028, Type: Literature]D(1A) dopamine receptor [gi:118229]
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14
[SID103167216]
IC50 0.00028Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate [AID63028, Type: Literature]D(1B) dopamine receptor [gi:118251]
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15
[SID103167216]
IC50 0.00028Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenate [AID63028, Type: Literature]D(4) dopamine receptor [gi:6226851]
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16
[SID103167216]
Ki 0.0003Evaluated for binding towards Dopamine receptor D2 using [3H]-spiperone as radioligand, in cloned mammalian receptors expressed in CHO-K1 cells [AID62338, Type: Literature]
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17
[SID103167216]
Ki 0.00033Tested for [3H](+)-pentazocine binding to sigma-1 receptor in guinea pig brain membrane [AID229213, Type: Literature]
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18
[SID103167216]
Ki 0.00033Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2 [AID65562, Type: Literature]D(2) dopamine receptor [gi:47117674]
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19
[SID103167216]
Ki 0.00037Binding affinity towards dopamine D2 receptors in rat brain synaptosomal preparations [AID65905, Type: Literature]D(2) dopamine receptor [gi:47117674]
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20
[SID103167216]
Ki 0.00037Compound was evaluated for its binding affinity with Dopamine receptor D2 using membranes prepared from rat striatum [AID65402, Type: Literature]
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21
[SID103167216]
IC50 0.0004Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol [AID63027, Type: Literature]D(2) dopamine receptor [gi:47117674]
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22
[SID103167216]
IC50 0.0004Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol [AID63027, Type: Literature]D(4) dopamine receptor [gi:6226851]
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23
[SID103167216]
IC50 0.0004Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol [AID63027, Type: Literature]D(1B) dopamine receptor [gi:118251]
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24
[SID103167216]
IC50 0.0004Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol [AID63027, Type: Literature]D(1A) dopamine receptor [gi:118229]
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25
[SID103167216]
IC50 0.0004Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidol [AID63027, Type: Literature]D(3) dopamine receptor [gi:118211]
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26
[SID103167216]
Ki 0.00044Displacement of [3H]raclopride from human dopamine D2A receptors expressed in LtK cells [AID61613, Type: Literature]D(2) dopamine receptor [gi:118206]
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27
[SID103167216]
Ki 0.00044Displacement of [3H]spiperone from CHO-K1 cell membranes expressing human dopamine receptor D2 [AID45419, Type: Literature]D(2) dopamine receptor [gi:118206]
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28
[SID103167216]
Ki 0.00044Inhibition of [3H]pentazocine binding to Sigma opioid receptor type 1 [AID204149, Type: other]
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29
[SID103167216]
Ki 0.00047In vitro binding affinity towards dopamine receptor D2 in rat striatal membranes by [3H]sulpiride displacement. [AID65740, Type: Literature]
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30
[SID103167216]
Ki 0.00047Binding affinity against dopamine receptor D2 from rat corpus striatum by using radioligand [3H]sulpiride [AID65078, Type: Literature]
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31
[SID103167216]
Ki 0.0005Tested for binding affinity towards human D2L receptor using [3H]spiperone as radioligand [AID64198, Type: Literature]
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32
[SID103167216]
Ki 0.0005Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239296, Type: Literature]
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33
[SID103167216]
Ki 0.00059Binding affinity was evaluated against Dopamine receptor D2 on rat striatum using [3H]spiperone as radioligand; ND = Not determined [AID63956, Type: Literature]D(2) dopamine receptor [gi:47117674]
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34
[SID103167216]
Ki 0.0006Binding affinity for Sigma opioid receptor type 1 in guinea pig brain homogenate with 0.5 nM [3H](+)-PENT [AID204147, Type: other]
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35
[SID103167216]
Ki 0.0006The compound was evaluated for affinity at sigma-1 site by inhibition of [3H](+)-pentazocine (PENT) binding in guinea pig brain. [AID203702, Type: Literature]
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36
[SID103167216]
Ki 0.000603Displacement of [3H]spiperone from human cloned dopamine D2 receptor [AID391273, Type: Literature]D(2) dopamine receptor [gi:118206]
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37
[SID103167216]
Ki 0.000603Displacement of [3H]spiperone from human cloned dopamine D2 receptor [AID439064, Type: Literature]D(2) dopamine receptor [gi:118206]
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38
[SID103167216]
IC50 0.00065Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay. [AID204762, Type: Literature]
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39
[SID103167216]
IC50 0.00065Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine [AID204763, Type: Literature]
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40
[SID103167216]
Ki 0.00066Inhibition of [3H]raclopride binding to Dopamine receptor D2 [AID63076, Type: Literature]D(2) dopamine receptor [gi:118206]
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41
[SID103167216]
Ki 0.00069Tested for binding affinity towards human D3 receptor using [3H]spiperone as radioligand [AID65280, Type: Literature]
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42
[SID103167216]
Ki 0.0007Evaluated for binding towards Dopamine receptor D2 using [3H]N-0437 as radioligand from rat striatal membrane [AID65559, Type: Literature]
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43
[SID103167216]
Ki 0.0007Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]U-86170 [AID62337, Type: Literature]D(2) dopamine receptor [gi:118205]
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44
[SID103167216]
Ki 0.00071Displacement of [3H]NPA from rat brain Dopamine receptor D2 [AID65713, Type: Literature]D(2) dopamine receptor [gi:47117674]
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45
[SID103167216]
Ki 0.00074Binding affinity towards human Dopamine receptor D4 using [3H]spiroperidol as radioligand [AID63533, Type: Literature]
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46
[SID103167216]
Ki 0.00075Binding affinity towards Dopamine receptor D2 [AID65239, Type: Literature]
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47
[SID103167216]
Ki 0.0008Binding affinity towards dopamine receptor D2 in rat striatal membranes [AID65245, Type: Literature]
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48
[SID103167216]
Ki 0.00083Displacement of [3H]-(+)-pentazocine from Sigma1-receptor in guinea pig brain membrane [AID578855, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81862796]
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49
[SID103167216]
Ki 0.00083Displacement of [3H](+)-PTZ from sigma1 receptor in Hartley guinea pig brain [AID317390, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81862796]
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50
[SID103167216]
Ki 0.00084In vitro binding affinity against human D2 dopamine receptor in CHO cells by [3H]spiperone displacement. [AID61316, Type: Literature]
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