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BioActivity Data for Compound 3-cyclohexyl-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CID 3523871)

BioActivity Outcomes:
Active(41)
 
 
Inactive(724)
 
 
Inconclusive(24)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(43)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(9)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(535)
 
 
 
 
Confirmatory(225)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(117)
 
 
Toxicity(8)
 
 
 
Cell-based(149)
 
 
 
Organism-base..(11)
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 717    Data Row: 790   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14743139]
IC50 1.7378Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC [AID504840, Type: confirmatory]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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2
[SID14743139]
Potency 2.3109qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling: Hit Validation in Primary Screen [AID651558, Type: confirmatory]
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3
[SID14743139]
Potency 3.1623qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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4
[SID14743139]
IC50 3.414Luminescent dose response cell-based high throughput screening assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1691, Type: confirmatory]
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5
[SID14743139]
Potency 4.6535Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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6
[SID14743139]
IC50 7.519Luminescent counterscreen for inhibitors of the Janus kinase 2 mutant JAK2V617F: dose response cell-based high throughput screening assay for inhibitors of parental Ba/F3 cell viability. [AID1699, Type: confirmatory]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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7
[SID14743139]
Potency 8.1995qHTS of GLP-1 Receptor Agonists: Hit Validation [AID743262, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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8
[SID14743139]
irf1 Inhibition [Ba/F3 cells] (IC50) 8.925Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. [AID2165_4, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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9
[SID14743139]
irf1 Inhibition [HEL cells] (IC50) 13.34Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. [AID2165_3, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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10
[SID14743139]
Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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11
[SID14743139]
Confirmation cell-based high throughput screening assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1521, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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12
[SID14743139]
Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. [AID2165, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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13
[SID14743139]
Luminescence-based cell-based primary high throughput confirmation assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652260, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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14
[SID14743139]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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15
[SID14743139]
Primary Cell-Based High-Throughput Screening to Identify Agonists of the Sphingosine 1-phosphate receptor 2 (S1P2) [AID729, Type: screening]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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16
[SID14743139]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]galanin receptor type 3 [Homo sapiens] [gi:4503907]
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17
[SID14743139]
Fluorescence-based cell-based primary high throughput confirmation assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID652245, Type: screening]galanin receptor type 3 [Homo sapiens] [gi:4503907]
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18
[SID14743139]
Primary cell based high-throughput screening assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2) [AID793, Type: screening]neuropeptide Y receptor type 2 [Homo sapiens] [gi:4505447]
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19
[SID14743139]
Primary cell-based high-throughput screening assay for antagonists of NPY-Y1 [AID1040, Type: screening]neuropeptide Y receptor type 1 [Homo sapiens] [gi:4505445]
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20
[SID14743139]
Counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay [AID493000, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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