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BioActivity Data for Compound Guanidine (CID 3520)

BioActivity Outcomes:
Active(1)
 
 
Unspecified(53)
 
 
Top Targets:
MFS(25)
 
 
BioAssay Types:
Literature(53)
 
 
BioAssay Categories:
In vitro(27)
 
 
Toxicity(4)
 
 
ADME(5)
 
 
Cell-based(44)
 
 
BioActivity Types:
Ki(4)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 54   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416076]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID103215917]
ED50 125Concentration of compound required to reduce by 50% the number of polio virus plaques in vero cells [AID217581, Type: Literature]
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3
[SID103215917]
IC50 171TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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4
[SID103215917]
Km 172TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681589, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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5
[SID103215917]
Ki 280TP_TRANSPORTER: inhibition of MPP+ uptake in OCT2-expressing HEK293 cells [AID679638, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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6
[SID103215917]
Ki 713.6TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells [AID681590, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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7
[SID103215917]
Ki 724.2TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells [AID681574, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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8
[SID103215917]
Km 730TP_TRANSPORTER: uptake in OCT2-expressing HEK293 cells [AID678807, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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9
[SID103215917]
Km 1660TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679822, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
View
10
[SID103215917]
IC50 4470TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
View
11
[SID103215917]
Ki 6201TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cells [AID681584, Type: Literature]Solute carrier family 22 member 3 [gi:24212063]
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12
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 5000 uM) in OCT3-expressing HRPE cells [AID680958, Type: Literature]Solute carrier family 22 member 3 [gi:24212075]
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13
[SID103215917]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679169, Type: Literature]Solute carrier family 22 member 3 [gi:24212075]
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14
[SID103215917]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, Guanidine: 5 uM) in Xenopus laevis oocytes [AID681054, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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15
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 500 uM, Guanidine: 5000 uM) in OCT1A expressing Xenopus laevis oocytes [AID679205, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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16
[SID103215917]
Dissociation constant, pKa of the compound [AID345041, Type: Literature]
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17
[SID103215917]
Ratio of the concentration levels determined for the adrenal medulla to the liver after 72 hr; [Adrenal Medulla] / [liver] [AID230956, Type: Literature]
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18
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 60 uM, Guanidine: 5000 uM) in Xenopus laevis oocytes [AID682100, Type: Literature]Solute carrier family 22 member 4 [gi:146345508]
View
19
[SID103215917]
Km TP_TRANSPORTER: uptake in OCT2A-expressing HEK293 cells [AID678793, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
View
20
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 5 uM, Guanidine: 1000 uM) in OCT2-expressing HEK293 cells [AID681990, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
View