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Guanidine (CID 3520) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Unspecified(52)
 
 
Top Targets:
MFS(25)
 
 
BioAssay Types:
Literature(52)
 
 
BioActivity Types:
Ki(4)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 53    Data Row: 53   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416076]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID103215917]
ED50 125Concentration of compound required to reduce by 50% the number of polio virus plaques in vero cells [AID217581, Type: Literature]
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3
[SID103215917]
IC50 171TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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4
[SID103215917]
Km 172TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681589, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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5
[SID103215917]
Ki 280TP_TRANSPORTER: inhibition of MPP+ uptake in OCT2-expressing HEK293 cells [AID679638, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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6
[SID103215917]
Ki 713.6TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells [AID681590, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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7
[SID103215917]
Ki 724.2TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells [AID681574, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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8
[SID103215917]
Km 730TP_TRANSPORTER: uptake in OCT2-expressing HEK293 cells [AID678807, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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9
[SID103215917]
Km 1660TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679822, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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10
[SID103215917]
IC50 4470TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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11
[SID103215917]
Ki 6201TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cells [AID681584, Type: Literature]Solute carrier family 22 member 3 [gi:24212063]
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12
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 5000 uM) in OCT3-expressing HRPE cells [AID680958, Type: Literature]Solute carrier family 22 member 3 [gi:24212075]
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13
[SID103215917]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679169, Type: Literature]Solute carrier family 22 member 3 [gi:24212075]
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14
[SID103215917]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, Guanidine: 5 uM) in Xenopus laevis oocytes [AID681054, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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15
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 500 uM, Guanidine: 5000 uM) in OCT1A expressing Xenopus laevis oocytes [AID679205, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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16
[SID103215917]
Ratio of the concentration levels determined for the adrenal medulla to the liver after 72 hr; [Adrenal Medulla] / [liver] [AID230956, Type: Literature]
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17
[SID103215917]
Dissociation constant, pKa of the compound [AID345041, Type: Literature]
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18
[SID103215917]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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19
[SID103215917]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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20
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 2500 uM) in OCTN2-expressing HRPE cells [AID681701, Type: Literature]Solute carrier family 22 member 5 [gi:8928242]
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