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Guanidine (CID 3520) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(1)
 
 
Unspecified(50)
 
 
Top Targets:
MFS(25)
 
 
BioAssay Types:
Literature(25)
 
 
BioActivity Types:
Ki(4)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 51   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416076]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID103215917]
ED50 125Concentration of compound required to reduce by 50% the number of polio virus plaques in vero cells [AID217581, Type: Literature]
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3
[SID103215917]
IC50 171TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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4
[SID103215917]
Km 172TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681589, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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5
[SID103215917]
Ki 280TP_TRANSPORTER: inhibition of MPP+ uptake in OCT2-expressing HEK293 cells [AID679638, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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6
[SID103215917]
Ki 713.6TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells [AID681590, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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7
[SID103215917]
Ki 724.2TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells [AID681574, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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8
[SID103215917]
Km 730TP_TRANSPORTER: uptake in OCT2-expressing HEK293 cells [AID678807, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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9
[SID103215917]
Km 1660TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679822, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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10
[SID103215917]
IC50 4470TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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11
[SID103215917]
Ki 6201TP_TRANSPORTER: inhibition of MPP+ uptake in OCT3-expressing HRPE cells [AID681584, Type: other]Solute carrier family 22 member 3 [gi:24212063]
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12
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 5000 uM) in OCT3-expressing HRPE cells [AID680958, Type: other]Solute carrier family 22 member 3 [gi:24212075]
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13
[SID103215917]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679169, Type: other]Solute carrier family 22 member 3 [gi:24212075]
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14
[SID103215917]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, Guanidine: 5 uM) in Xenopus laevis oocytes [AID681054, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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15
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 500 uM, Guanidine: 5000 uM) in OCT1A expressing Xenopus laevis oocytes [AID679205, Type: other]Solute carrier family 22 member 1 [gi:81872095]
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16
[SID103215917]
Ratio of the concentration levels determined for the adrenal medulla to the liver after 72 hr; [Adrenal Medulla] / [liver] [AID230956, Type: Literature]
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17
[SID103215917]
Dissociation constant, pKa of the compound [AID345041, Type: Literature]
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18
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 2500 uM) in OCTN2-expressing HRPE cells [AID681701, Type: other]Solute carrier family 22 member 5 [gi:8928242]
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19
[SID103215917]
Km TP_TRANSPORTER: uptake in OCTN2-expressing HEK293 cells [AID681169, Type: other]Solute carrier family 22 member 5 [gi:8928257]
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20
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM, Guanidine: 5000 uM) in OCTN2-expressing HeLa cells [AID682268, Type: other]Solute carrier family 22 member 5 [gi:8928257]
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21
[SID103215917]
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.010? uM, Guanidine: 500 uM) in OCTN2-expressing HEK293 cells [AID682308, Type: other]Solute carrier family 22 member 5 [gi:8928257]
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22
[SID103215917]
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.01 uM, Guanidine: 500 uM) in OCTN2-expressing HEK293 cells [AID680540, Type: other]Solute carrier family 22 member 5 [gi:8928277]
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23
[SID103215917]
Km TP_TRANSPORTER: uptake in OCT3-expressing HeLa cells [AID680325, Type: other]Solute carrier family 22 member 3 [gi:24212062]
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24
[SID103215917]
TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID682218, Type: other]Solute carrier family 22 member 3 [gi:24212062]
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25
[SID103215917]
Distribution in dog adrenal medulla 30 min after administration. [AID15565, Type: Literature]
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26
[SID103215917]
Distribution in dog adrenal medulla 72 hours after administration. [AID15566, Type: Literature]
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27
[SID103215917]
pKa was determined [AID26079, Type: Literature]
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28
[SID103215917]
pKa value determined [AID26313, Type: Literature]
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29
[SID103215917]
Antiviral activity against the Coxsackie B5 virus (RNA virus) at a concentration of 3 ug/mL was determined as total cell infectious dose 50/mL (TCID50) by viral yield assay [AID54675, Type: Literature]
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30
[SID103215917]
Antiviral activity against the Coxsackie B5 virus (RNA virus) at a concentration of 80 ug/mL was determined as total cell infectious dose 50/mL (TCID50) by viral yield assay [AID54678, Type: Literature]
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31
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 14 which were grown on Ohio HeLa cells [AID199699, Type: Literature]
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32
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 15 which were grown on Ohio HeLa cells [AID199700, Type: Literature]
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33
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 2 which were grown on Ohio HeLa cells [AID199701, Type: Literature]
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34
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 29 which were grown on Ohio HeLa cells [AID199702, Type: Literature]
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35
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 39 which were grown on Ohio HeLa cells [AID199703, Type: Literature]
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36
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 41 which were grown on Ohio HeLa cells [AID199704, Type: Literature]
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37
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 59 which were grown on Ohio HeLa cells [AID199705, Type: Literature]
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38
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 63 which were grown on Ohio HeLa cells [AID199706, Type: Literature]
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39
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 70 which were grown on Ohio HeLa cells [AID199707, Type: Literature]
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40
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 85 which were grown on Ohio HeLa cells [AID199708, Type: Literature]
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41
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 89 which were grown on Ohio HeLa cells [AID199709, Type: Literature]
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42
[SID103215917]
Antirhinovirus activity against rhinovirus serotype 9 which were grown on Ohio HeLa cells [AID199710, Type: Literature]
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43
[SID103215917]
Cytotoxicity on the vero cell culture infected with Coxsackie B5 virus at a concentration of 3 ug/mL was determined as cell viability by the MTT test [AID217415, Type: Literature]
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44
[SID103215917]
Cytotoxicity on the vero cell culture infected with Coxsackie B5 virus at a concentration of 80 ug/mL was determined as cell viability by the MTT test [AID217418, Type: Literature]
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45
[SID103215917]
Cytotoxicity on the vero cell culture infected with mL and was determined as reduction in protein content by the Lowry test [AID217426, Type: Literature]
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46
[SID103215917]
Cytotoxicity on the vero cell culture infected with mL and was determined as reduction in protein content by the Lowry test [AID217429, Type: Literature]
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47
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 60 uM, Guanidine: 5000 uM) in Xenopus laevis oocytes [AID682100, Type: other]Solute carrier family 22 member 4 [gi:146345508]
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48
[SID103215917]
Km TP_TRANSPORTER: uptake in OCT2-expressing HEK293 cells [AID679158, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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49
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 5 uM, Guanidine: 1000 uM) in OCT2A-expressing HEK293 cells [AID681989, Type: other]Solute carrier family 22 member 2 [gi:313104182]
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50
[SID103215917]
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 5 uM, Guanidine: 1000 uM) in OCT2-expressing HEK293 cells [AID681990, Type: other]Solute carrier family 22 member 2 [gi:313104182]
View