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BioActivity Data for Compound Guanethidine (CID 3518)

BioActivity Outcomes:
Active(4)
 
 
Inactive(177)
 
 
Inconclusive(22)
 
 
Unspecified(286)
 
 
Top Targets:
7tm 4(31)
 
 
p450(17)
 
 
 
HSD10-like SD..(4)
 
 
STKc ERK1 2 l..(4)
 
 
 
NR LBD GR(3)
 
 
 
BioAssay Types:
Confirmatory(223)
 
 
 
 
Literature(147)
 
 
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(81)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 418    Data Row: 489   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using iNOS (nitric oxide synthases) [AID92306, Type: Literature]
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2
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using nNOS (nitric oxide synthases) [AID146288, Type: Literature]
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3
[SID85209451]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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4
[SID48416075]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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5
[SID103203421]
Distribution in dog adrenal medulla 30 min after administration. [AID15565, Type: Literature]
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6
[SID103203421]
Distribution in dog adrenal medulla 72 hours after administration. [AID15566, Type: Literature]
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7
[SID11112157]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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8
[SID103203421]
Blood pressure change in rats after oral administration of 50 mg/kg dose after 4 hours [AID186701, Type: Literature]
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9
[SID103203421]
Maximum rate of rise of the left ventricular isovolumetric pressure was measured after iv administration of 25 uM/kg in anesthetized rats; ratio given for dP/dt [AID192754, Type: Literature]
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10
[SID103203421]
Maximum rate of rise of the left ventricular isovolumetric pressure administered at 25 uM/kg iv in anesthetized rats [AID192802, Type: Literature]
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11
[SID103203421]
Maximum rate of rise of the left ventricular isovolumetric pressure in anesthetized rats by i.v. administration [AID193681, Type: Literature]
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12
[SID103203421]
Percent change in diastolic blood pressure (mmHg)in anesthetized rats by i.v. administration [AID193687, Type: Literature]
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13
[SID103203421]
Percent change in heart rate expressed in beats / min in anesthetized rats by i.v. administration [AID193688, Type: Literature]
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14
[SID103203421]
Change in diastolic blood pressure after iv administration of 25 uM/kg in anesthetized rats [AID171655, Type: Literature]
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15
[SID103203421]
Change in systolic blood pressure after iv administration of 25 uM/kg in anesthetized rats [AID171813, Type: Literature]
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16
[SID103203421]
Antihypertensive activity was measured for systolic pressure using spontaneous hypertensive rats (SHR) at 10 mg/kg after oral administration [AID172424, Type: Literature]
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17
[SID103203421]
Change in heart rate after iv administration of 25 uM/kg in anesthetized rats [AID180651, Type: Literature]
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18
[SID103203421]
Tested for change in heart rate administered at 25 uM/kg iv in anesthetized rats [AID180831, Type: Literature]
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19
[SID103203421]
Blood pressure change in rats after oral administration of 50 mg/kg dose after 24 hours [AID186699, Type: Literature]
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20
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 4 hours of postdose-1 [AID171470, Type: Literature]
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