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Guanethidine (CID 3518) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(177)
 
 
Inconclusive(22)
 
 
Unspecified(275)
 
 
Top Targets:
p450(17)
 
 
 
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(15)
 
 
HSD10-like SD..(4)
 
 
STKc ERK1 2 l..(4)
 
 
 
BioAssay Types:
Confirmatory(223)
 
 
 
 
Literature(136)
 
 
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(81)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 407    Data Row: 478   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using iNOS (nitric oxide synthases) [AID92306, Type: Literature]
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2
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using nNOS (nitric oxide synthases) [AID146288, Type: Literature]
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3
[SID85209451]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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4
[SID48416075]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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5
[SID11112157]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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6
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: confirmatory]5-hydroxytryptamine receptor 6 [gi:1703010]
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7
[SID103203421]
IC50 DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) [AID625209, Type: confirmatory]Type-2 angiotensin II receptor [gi:1703214]
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8
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) [AID625238, Type: confirmatory]C-C chemokine receptor type 4 [gi:1705894]
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9
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) [AID625239, Type: confirmatory]C-C chemokine receptor type 5 [gi:1705896]
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10
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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11
[SID103203421]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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12
[SID103203421]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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13
[SID103203421]
IC50 DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: confirmatory]Aldose reductase [gi:1168407]
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14
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) [AID625237, Type: confirmatory]C-C chemokine receptor type 2 [gi:1168965]
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15
[SID103203421]
IC50 DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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16
[SID103203421]
IC50 DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone) [AID625255, Type: confirmatory]D(4) dopamine receptor [gi:1345939]
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17
[SID103203421]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: confirmatory]Alpha-2A adrenergic receptor [gi:1351829]
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18
[SID103203421]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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19
[SID103203421]
IC50 DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) [AID625241, Type: confirmatory]C-X-C chemokine receptor type 2 [gi:1352454]
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20
[SID103203421]
IC50 DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) [AID625157, Type: confirmatory]Neuropeptide Y receptor type 2 [gi:1352610]
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