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BioActivity Data for Compound Guanethidine (CID 3518)

BioActivity Outcomes:
Active(4)
 
 
Inactive(177)
 
 
Inconclusive(22)
 
 
Unspecified(286)
 
 
Top Targets:
7tm 4(30)
 
 
p450(17)
 
 
 
HSD10-like SD..(4)
 
 
STKc ERK1 2 l..(4)
 
 
 
ePHD KMT2A(3)
 
 
BioAssay Types:
Confirmatory(223)
 
 
 
 
Literature(147)
 
 
 
 
 
Screening(1)
 
 
BioAssay Categories:
In vitro(132)
 
 
In vivo(87)
 
 
Biochemical(135)
 
 
 
Toxicity(90)
 
 
 
ADME(19)
 
 
Cell-based(82)
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(81)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 418    Data Row: 489   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85209451]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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2
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using iNOS (nitric oxide synthases) [AID92306, Type: Literature]
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3
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using nNOS (nitric oxide synthases) [AID146288, Type: Literature]
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4
[SID48416075]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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5
[SID11112157]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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6
[SID103203421]
Tested for the change in diastolic blood pressure administered at 25 ug/kg intravenously in anesthetized rats [AID170668, Type: Literature]
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7
[SID103203421]
Tested for the change in systolic blood pressure administered at 25 ug/kg intravenously in anesthetized rats [AID170836, Type: Literature]
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8
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 25 mg/kg, p.o. after 24 hours of postdose-1 [AID171307, Type: Literature]
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9
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 25 mg/kg, p.o. after 24 hours of postdose-2 [AID171308, Type: Literature]
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10
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 25 mg/kg, po after 4 hours of postdose-1 [AID171309, Type: Literature]
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11
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 25 mg/kg, p.o. after 4 hours of postdose-2 [AID171311, Type: Literature]
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12
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 25 mg/kg, p.o. before predose [AID171312, Type: Literature]
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13
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 24 hours of postdose-1 [AID171328, Type: Literature]
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14
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 24 hours of postdose-1 [AID171329, Type: Literature]
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15
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 24 hours of postdose-2 [AID171330, Type: Literature]
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16
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 24 hours of postdose-2 [AID171468, Type: Literature]
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17
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 4 hours of postdose-1 [AID171469, Type: Literature]
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18
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 4 hours of postdose-1 [AID171470, Type: Literature]
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19
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, p.o. after 4 hours of postdose-2 [AID171471, Type: Literature]
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20
[SID103203421]
Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 50 mg/kg, po after 4 hours of postdose-2 [AID171472, Type: Literature]
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