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Guanethidine (CID 3518) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(177)
 
 
Inconclusive(22)
 
 
Unspecified(188)
 
 
Top Targets:
p450(17)
 
 
 
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(15)
 
 
HSD10-like SD..(4)
 
 
STKc ERK1 2 l..(4)
 
 
 
BioAssay Types:
Literature(136)
 
 
 
 
 
Confirmatory(107)
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(81)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 320    Data Row: 391   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using iNOS (nitric oxide synthases) [AID92306, Type: Literature]
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2
[SID103203421]
NO releasing ability of compound measured through formation of nitrite using nNOS (nitric oxide synthases) [AID146288, Type: Literature]
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3
[SID85209451]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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4
[SID48416075]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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5
[SID11112157]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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6
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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7
[SID103203421]
IC50 DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) [AID625209, Type: other]Type-2 angiotensin II receptor [gi:1703214]
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8
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) [AID625238, Type: other]C-C chemokine receptor type 4 [gi:1705894]
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9
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) [AID625239, Type: other]C-C chemokine receptor type 5 [gi:1705896]
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10
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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11
[SID103203421]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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12
[SID103203421]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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13
[SID103203421]
IC50 DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: other]Aldose reductase [gi:1168407]
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14
[SID103203421]
IC50 DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) [AID625237, Type: other]C-C chemokine receptor type 2 [gi:1168965]
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15
[SID103203421]
IC50 DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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16
[SID103203421]
IC50 DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone) [AID625255, Type: other]D(4) dopamine receptor [gi:1345939]
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17
[SID103203421]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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18
[SID103203421]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A3 [gi:1351831]
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19
[SID103203421]
IC50 DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) [AID625241, Type: other]C-X-C chemokine receptor type 2 [gi:1352454]
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20
[SID103203421]
IC50 DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) [AID625157, Type: other]Neuropeptide Y receptor type 2 [gi:1352610]
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21
[SID103203421]
IC50 DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) [AID625183, Type: other]Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [gi:1352673]
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22
[SID103203421]
IC50 DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: other]Estrogen receptor beta [gi:6166154]
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23
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) [AID625220, Type: other]5-hydroxytryptamine receptor 4 [gi:6224984]
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24
[SID103203421]
IC50 DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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25
[SID103203421]
IC50 DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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26
[SID103203421]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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27
[SID103203421]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: other]Mitogen-activated protein kinase 14 [gi:2499600]
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28
[SID103203421]
IC50 DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) [AID625213, Type: other]B2 bradykinin receptor [gi:2506481]
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29
[SID103203421]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
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30
[SID103203421]
IC50 DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: other]Angiotensin-converting enzyme [gi:2822103]
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31
[SID103203421]
IC50 DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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32
[SID103203421]
IC50 DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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33
[SID103203421]
IC50 DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: other]Cysteinyl leukotriene receptor 1 [gi:20138087]
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34
[SID103203421]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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35
[SID103203421]
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) [AID625188, Type: other]Receptor-type tyrosine-protein phosphatase C [gi:33112650]
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36
[SID103203421]
IC50 DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625148, Type: other]Melanocortin receptor 4 [gi:60392672]
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37
[SID103203421]
IC50 DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: other]Cytochrome P450 2C19 [gi:60416369]
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38
[SID103203421]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A1 [gi:231473]
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39
[SID103203421]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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40
[SID103203421]
IC50 DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) [AID625174, Type: other]Caspase-1 [gi:266321]
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41
[SID103203421]
IC50 DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) [AID625159, Type: other]Nitric oxide synthase, brain [gi:266646]
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42
[SID103203421]
DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) [AID625160, Type: other]Nitric oxide synthase, inducible [gi:266649]
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43
[SID103203421]
IC50 DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
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44
[SID103203421]
IC50 DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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45
[SID103203421]
IC50 DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) [AID625242, Type: other]Cholecystokinin receptor type A [gi:416772]
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46
[SID103203421]
DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) [AID625232, Type: other]Vasoactive intestinal polypeptide receptor 1 [gi:418253]
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47
[SID103203421]
IC50 DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) [AID625206, Type: other]Beta-3 adrenergic receptor [gi:461604]
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48
[SID103203421]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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49
[SID103203421]
IC50 DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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50
[SID103203421]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2a [gi:543740]
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