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2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide (CID 3499) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(34)
 
 
Inconclusive(3)
 
 
Unspecified(518)
 
 
Top Targets:
PKc(50)
 
 
PKc like(46)
 
 
STKc AGC(26)
 
 
CYCLIN(24)
 
 
PTKc Src like(12)
 
 
BioAssay Types:
Confirmatory(29)
 
 
 
 
Screening(5)
 
 
Literature(2)
 
 
BioActivity Types:
Potency(29)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 502    Data Row: 556   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26756888]
Potency 7.0795qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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2
[SID103568539]
Millipore: Percentage of residual kinase activity of GRK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720175, Type: other]G protein-coupled receptor kinase 5 [gi:462203]
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3
[SID103568539]
Millipore: Percentage of residual kinase activity of GRK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720176, Type: other]G protein-coupled receptor kinase 5 [gi:462203]
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4
[SID103568539]
Millipore: Percentage of residual kinase activity of PRKCG at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol [AID720478, Type: other]Protein kinase C gamma type [gi:462455]
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5
[SID103568539]
Millipore: Percentage of residual kinase activity of PRKCG at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol [AID720479, Type: other]Protein kinase C gamma type [gi:462455]
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6
[SID103568539]
Millipore: Percentage of residual kinase activity of PDGFRB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720460, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
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7
[SID103568539]
Millipore: Percentage of residual kinase activity of PDGFRB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720461, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
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8
[SID103568539]
Millipore: Percentage of residual kinase activity of PDGFRA at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720458, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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9
[SID103568539]
Millipore: Percentage of residual kinase activity of PDGFRA at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720459, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
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10
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720061, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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11
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720062, Type: other]Cyclin-dependent kinase 3 [gi:231726]
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12
[SID103568539]
Millipore: Percentage of residual kinase activity of MAPK3 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA [AID720338, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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13
[SID103568539]
Millipore: Percentage of residual kinase activity of MAPK3 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA [AID720339, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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14
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720068, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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15
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720067, Type: other]Cyclin-dependent kinase 6 [gi:266423]
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16
[SID103568539]
Millipore: Percentage of residual kinase activity of PRKCE at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol [AID720482, Type: other]Protein kinase C epsilon type [gi:400135]
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17
[SID103568539]
Millipore: Percentage of residual kinase activity of PRKCE at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol [AID720483, Type: other]Protein kinase C epsilon type [gi:400135]
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18
[SID103568539]
Millipore: Percentage of residual kinase activity of MAP2K1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 [AID720348, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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19
[SID103568539]
Millipore: Percentage of residual kinase activity of MAP2K1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 [AID720349, Type: other]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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20
[SID103568539]
Millipore: Percentage of residual kinase activity of GCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA [AID720173, Type: other]Glucokinase [gi:547696]
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21
[SID103568539]
Millipore: Percentage of residual kinase activity of GCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA [AID720174, Type: other]Glucokinase [gi:547696]
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22
[SID103568539]
Millipore: Percentage of residual kinase activity of BTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720045, Type: other]Tyrosine-protein kinase BTK [gi:547759]
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23
[SID103568539]
Millipore: Percentage of residual kinase activity of BTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720046, Type: other]Tyrosine-protein kinase BTK [gi:547759]
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24
[SID103568539]
Millipore: Percentage of residual kinase activity of CSF1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720169, Type: other]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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25
[SID103568539]
Millipore: Percentage of residual kinase activity of CSF1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720170, Type: other]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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26
[SID103568539]
Millipore: Percentage of residual kinase activity of ACVR1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720021, Type: other]Activin receptor type-1B [gi:547775]
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27
[SID103568539]
Millipore: Percentage of residual kinase activity of ACVR1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720022, Type: other]Activin receptor type-1B [gi:547775]
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28
[SID103568539]
Millipore: Percentage of residual kinase activity of TGFBR1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 [AID720294, Type: other]TGF-beta receptor type-1 [gi:547777]
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29
[SID103568539]
Millipore: Percentage of residual kinase activity of TGFBR1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 [AID720295, Type: other]TGF-beta receptor type-1 [gi:547777]
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30
[SID103568539]
Millipore: Percentage of residual kinase activity of RET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720242, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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31
[SID103568539]
Millipore: Percentage of residual kinase activity of RET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720243, Type: other]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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32
[SID103568539]
Millipore: Percentage of residual kinase activity of ITK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720312, Type: other]Tyrosine-protein kinase ITK/TSK [gi:585361]
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33
[SID103568539]
Millipore: Percentage of residual kinase activity of ITK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720313, Type: other]Tyrosine-protein kinase ITK/TSK [gi:585361]
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34
[SID103568539]
Millipore: Percentage of residual kinase activity of CSK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 [AID720093, Type: other]Tyrosine-protein kinase CSK [gi:729887]
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35
[SID103568539]
Millipore: Percentage of residual kinase activity of CSK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 [AID720094, Type: other]Tyrosine-protein kinase CSK [gi:729887]
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36
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720057, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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37
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720058, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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38
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720059, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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39
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720060, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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40
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720056, Type: other]G2/mitotic-specific cyclin-B1 [gi:116176]
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41
[SID103568539]
Millipore: Percentage of residual kinase activity of CDK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720055, Type: other]G2/mitotic-specific cyclin-B1 [gi:116176]
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42
[SID103568539]
Millipore: Percentage of residual kinase activity of MAPK1 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA [AID720340, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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43
[SID103568539]
Millipore: Percentage of residual kinase activity of MAPK1 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA [AID720341, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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44
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720149, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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45
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720150, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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46
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 [AID720151, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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47
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 [AID720152, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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48
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720153, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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49
[SID103568539]
Millipore: Percentage of residual kinase activity of FGFR3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720154, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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50
[SID103568539]
Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol [AID720197, Type: other]Insulin-like growth factor 1 receptor [gi:124240]
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