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F1031-0076 (CID 3491105) - Compound BioActivity Data
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BioActivity Outcomes:
Active(65)
 
 
Inactive(633)
 
 
Inconclusive(38)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(19)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(499)
 
 
 
 
Confirmatory(214)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(46)
 
 
 
 
 
EC50(12)
 
 
 
AC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 667    Data Row: 738   Total Pages: 37   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24832178]
AC50_uM 1.33ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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2
[SID24832178]
AC50_uM 1.33ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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3
[SID24832178]
AC50_uM 1.84Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_Dose_CherryPick_Activity [AID720495, Type: confirmatory]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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4
[SID24832178]
IC50 2.477Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Protein Phosphatase 1 (PP1) [AID2403, Type: confirmatory]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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5
[SID24832178]
Potency 2.8184qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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6
[SID24832178]
Potency 3.5481qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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7
[SID24832178]
EC50 6.016Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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8
[SID24832178]
Potency 7.0795qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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9
[SID24832178]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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10
[SID24832178]
Potency 7.9433qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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11
[SID24832178]
IC50 8.018Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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12
[SID24832178]
AC50_uM 8.13ARNT-TACC3: counter AlphaScreen Measured in Biochemical System Using Plate Reader - 2158-02_Inhibitor_Dose_CherryPick_Activity [AID651705, Type: confirmatory]
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13
[SID24832178]
AC50_uM 8.67Alphascreen Interference Assay Measured in Biochemical System Using Plate Reader - 2160-02_Inhibitor_Dose_CherryPick_Activity [AID720494, Type: confirmatory]
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14
[SID24832178]
EC50 8.878Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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15
[SID24832178]
IC50 9.046Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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16
[SID24832178]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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17
[SID24832178]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID24832178]
Potency 14.581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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19
[SID24832178]
EC50 15.405Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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20
[SID24832178]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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