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Gemfibrozil (CID 3463) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(1650)
 
 
Inconclusive(81)
 
 
Unspecified(2326)
 
 
Top Targets:
7tm 4(81)
 
 
 
NR LBD PPAR(53)
 
 
 
 
 
NR LBD ER(32)
 
 
 
 
p450(28)
 
 
 
 
 
NR LBD AR(27)
 
 
 
 
BioAssay Types:
Confirmatory(927)
 
 
 
 
 
Screening(672)
 
 
 
Literature(350)
 
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(722)
 
 
 
 
 
IC50(171)
 
 
 
 
EC50(16)
 
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3414    Data Row: 4088   Total Pages: 205   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166445]
Ki 1.86Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay [AID407366, Type: Literature]Fatty acid-binding protein, liver [gi:119810]
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2
[SID103166445]
IC50 4.0738pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells [AID977600, Type: Literature]
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3
[SID103166445]
IC50 4.1Inhibition of CYP2C8 [AID705607, Type: Literature]
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4
[SID11112705]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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5
[SID103166445]
IC50 7.07946pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells [AID977603, Type: Literature]
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6
[SID103166445]
IC50 9.6Reversible inhibition of CYP2C9 in human liver microsomes [AID705589, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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7
[SID855780]
Potency 19.9526VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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8
[SID144209195]
Potency-Replicate_1 48.9036qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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9
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_14, Type: screening]oxysterols receptor LXR-beta isoform 1 [Homo sapiens] [gi:85362735]
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10
[SID11112705]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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11
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_24, Type: screening]COUP transcription factor 1 [Homo sapiens] [gi:5032173]
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12
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_46, Type: screening]retinoic acid receptor alpha isoform 1 [Homo sapiens] [gi:4506419]
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13
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_47, Type: screening]retinoic acid receptor alpha isoform 1 [Homo sapiens] [gi:4506419]
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14
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_50, Type: screening]retinoic acid receptor gamma isoform 1 [Homo sapiens] [gi:4506423]
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15
[SID103166445]
Agonist activity at PPARalpha in human HepG2 cells assessed as upregulation of CPT1a mRNA expression at 0.1 to 100 uM after 24 hrs by quantitative RT-PCR analysis [AID620231, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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16
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_52, Type: screening]nuclear receptor ROR-alpha isoform c [Homo sapiens] [gi:4506577]
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17
[SID855780]
High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary Screen [AID1066, Type: screening]acetyl-CoA acetyltransferase/HMG-CoA reductase [Enterococcus faecalis] [gi:9937384]
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18
[SID11112705]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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19
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_36, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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20
[SID87219219]
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors. [AID2277_37, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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