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GW 7647 (CID 3392731) - Compound BioActivity Data
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BioActivity Outcomes:
Active(85)
 
 
Inactive(714)
 
 
Inconclusive(104)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD PPAR(40)
 
 
 
 
 
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(16)
 
 
p450(12)
 
 
 
 
NR LBD TR(10)
 
 
 
BioAssay Types:
Confirmatory(470)
 
 
 
 
 
Screening(340)
 
 
 
 
Literature(86)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(410)
 
 
 
 
 
EC50(23)
 
 
 
 
IC50(18)
 
 
 
 
AC50(3)
 
 
Kd(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 737    Data Row: 927   Total Pages: 47   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103187301]
IC50 0.00046Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay [AID683294, Type: Literature]
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2
[SID103187301]
EC50 0.0006Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control [AID688612, Type: Literature]
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3
[SID103187301]
EC50 0.001Activation of murine PPAR alpha ligand binding domain [AID142312, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
4
[SID103187301]
Kd 0.001Binding affinity to human PPARalpha (unknown origin) by competitive TR-FRET assay [AID731521, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID103187301]
EC50 0.0018Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay [AID675854, Type: Literature]
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6
[SID103187301]
EC50 0.006In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain [AID156137, Type: Literature]
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7
[SID26752230]
Potency 0.0158qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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8
[SID103187301]
EC50 0.05Agonist activity at human PPARalpha [AID677054, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
9
[SID103187301]
EC50 0.178Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay [AID388012, Type: Literature]
View
10
[SID103187301]
Kd 0.18Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay [AID731519, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
11
[SID103187301]
EC50 0.2Transactivation of GAL4-fused human PPARalpha ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay [AID709645, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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12
[SID103187301]
EC50 0.2Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay [AID718853, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
13
[SID103187301]
EC50 0.2Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay [AID609349, Type: Literature]
View
14
[SID103187301]
EC50 0.2Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay [AID693448, Type: Literature]
View
15
[SID103187301]
EC50 0.2Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay [AID438409, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
16
[SID103187301]
EC50 0.2Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay [AID620228, Type: Literature]
View
17
[SID103187301]
EC50 0.23Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay [AID473107, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
18
[SID103187301]
EC50 0.4Agonist activity at human PPARalpha LBD by cell based luciferase reporter gene assay [AID569826, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
19
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
20
[SID103187301]
EC50 1.3Activation of murine PPAR gamma ligand binding domain [AID142314, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View