GW 7647 (CID 3392731) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(64)
 
 
Inactive(593)
 
 
Inconclusive(92)
 
 
Unspecified(20)
 
 
Top Targets:
NR LBD PPAR(22)
 
 
 
 
 
7TM GPCR Srx(19)
 
 
 
 
p450(13)
 
 
 
 
 
NR LBD TR(10)
 
 
 
Pyr redox dim(8)
 
 
 
BioAssay Types:
Confirmatory(403)
 
 
 
 
 
Screening(284)
 
 
 
 
Literature(52)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(343)
 
 
 
 
 
IC50(16)
 
 
 
EC50(14)
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 642    Data Row: 769   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103187301]
IC50 0.00046Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay [AID683294, Type: Literature]
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2
[SID103187301]
EC50 0.001Activation of murine PPAR alpha ligand binding domain [AID142312, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
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3
[SID103187301]
EC50 0.0018Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay [AID675854, Type: Literature]
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4
[SID103187301]
EC50 0.006In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain [AID156137, Type: Literature]
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5
[SID26752230]
Potency 0.0158qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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6
[SID26752230]
Potency 0.0158qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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7
[SID103187301]
EC50 0.05Agonist activity at human PPARalpha [AID677054, Type: Literature]
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8
[SID103187301]
EC50 0.178Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay [AID388012, Type: Literature]
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9
[SID103187301]
EC50 0.2Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay [AID609349, Type: Literature]
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10
[SID103187301]
EC50 0.2Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay [AID620228, Type: Literature]
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11
[SID103187301]
EC50 0.2Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay [AID438409, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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12
[SID103187301]
EC50 0.2Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay [AID438409, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
13
[SID103187301]
EC50 0.23Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay [AID473107, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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14
[SID103187301]
EC50 0.23Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay [AID473107, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
15
[SID103187301]
EC50 0.4Agonist activity at human PPARalpha LBD by cell based luciferase reporter gene assay [AID569826, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
16
[SID103187301]
EC50 0.4Agonist activity at human PPARalpha LBD by cell based luciferase reporter gene assay [AID569826, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
17
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
18
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
19
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
20
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
21
[SID103187301]
EC50 1.3Activation of murine PPAR gamma ligand binding domain [AID142314, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
22
[SID103187301]
EC50 2.9Activation of murine PPAR delta ligand binding domain [AID142313, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
View
23
[SID11114179]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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24
[SID11114179]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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25
[SID11114179]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
26
[SID56463261]
IC50 4.4Fluorescence-based biochemical high throughput dose response assay to identify molecules that bind r(CAG) RNA repeats [AID686959, Type: confirmatory]
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27
[SID56463261]
AC50 4.459Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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28
[SID11111235]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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29
[SID11111235]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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30
[SID11111235]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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31
[SID56463261]
AC50 5.568Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
View
32
[SID103187301]
EC50 6.2In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain [AID156359, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
33
[SID103187301]
EC50 6.2In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain [AID156359, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
34
[SID103187301]
EC50 6.2In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain [AID156359, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
35
[SID103187301]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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36
[SID90340884]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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37
[SID90340884]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
38
[SID90340884]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
39
[SID90340884]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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40
[SID103187301]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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41
[SID90340884]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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42
[SID90340884]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
View
43
[SID50104932]
Potency 12.5893Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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44
[SID11114179]
Potency 14.1254qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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45
[SID11114179]
Potency 14.1254qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
View
46
[SID11114179]
Potency 14.1254qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
View
47
[SID11114179]
Potency 14.1254qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
View
48
[SID26752230]
Potency 15.8489qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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49
[SID26752230]
Potency 15.8489qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
50
[SID26752230]
Potency 15.8489qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View