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GW 7647 (CID 3392731) - Compound BioActivity Data
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BioActivity Outcomes:
Active(82)
 
 
Inactive(702)
 
 
Inconclusive(103)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD PPAR(40)
 
 
 
 
 
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(16)
 
 
p450(12)
 
 
 
 
NR LBD TR(10)
 
 
 
BioAssay Types:
Confirmatory(466)
 
 
 
 
 
Screening(336)
 
 
 
 
Literature(77)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(404)
 
 
 
 
 
EC50(22)
 
 
 
 
IC50(17)
 
 
 
 
AC50(3)
 
 
Kd(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 727    Data Row: 909   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103187301]
IC50 0.00046Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay [AID683294, Type: Literature]
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2
[SID103187301]
EC50 0.0006Activation of PPARalpha transfected in HEK293 cells after 18 hrs by firefly luciferase reporter gene-based luminescence assay relative to control [AID688612, Type: Literature]
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3
[SID103187301]
EC50 0.001Activation of murine PPAR alpha ligand binding domain [AID142312, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
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4
[SID103187301]
Kd 0.001Binding affinity to human PPARalpha (unknown origin) by competitive TR-FRET assay [AID731521, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID103187301]
EC50 0.0018Displacement of pan-PPAR fluormone from PPARalpha LBD by TR-FRET based LanthaScreen assay [AID675854, Type: Literature]
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6
[SID103187301]
EC50 0.006In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain [AID156137, Type: Literature]
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7
[SID26752230]
Potency 0.0158qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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8
[SID103187301]
EC50 0.05Agonist activity at human PPARalpha [AID677054, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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9
[SID103187301]
EC50 0.178Agonist activity at human PPARalpha expressed in human MCF7 cells coexpressing TIF2 by luciferase reporter gene assay [AID388012, Type: Literature]
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10
[SID103187301]
Kd 0.18Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay [AID731519, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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11
[SID103187301]
EC50 0.2Transactivation of GAL4-fused human PPARalpha ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay [AID709645, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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12
[SID103187301]
EC50 0.2Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay [AID438409, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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13
[SID103187301]
EC50 0.2Transactivation of human GAL4-fused PPARalpha ligand binding domain transfected in HEK293 cells after 18 hrs by dual luciferase reporter gene assay [AID718853, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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14
[SID103187301]
EC50 0.2Transactivation of PPARalpha expressed in HEK293A cells co-expressing GAL4 after 16 to 18 hrs by luciferase reporter gene assay [AID693448, Type: Literature]
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15
[SID103187301]
EC50 0.2Agonist activity at PPARalpha ligand binding domain expressed in HEK293 cells co-expressing GAL4 after 18 hrs by dual-luciferase activity based transactivation assay [AID609349, Type: Literature]
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16
[SID103187301]
EC50 0.2Agonist activity at Gal4-fused PPARalpha expressed in HEK293 cells after 18 hrs by dual luciferase reporter gene assay [AID620228, Type: Literature]
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17
[SID103187301]
EC50 0.23Transactivation of human PPARalpha LBD expressed in african green monkey Cos7 cells co-transfected with fused GAL4-DBD after 14 hrs by Dual-Glo Luciferase reporter gene assay [AID473107, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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18
[SID103187301]
EC50 0.4Agonist activity at human PPARalpha LBD by cell based luciferase reporter gene assay [AID569826, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
19
[SID103187301]
EC50 1.1In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain [AID156937, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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20
[SID103187301]
EC50 1.3Activation of murine PPAR gamma ligand binding domain [AID142314, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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21
[SID103187301]
EC50 2.9Activation of murine PPAR delta ligand binding domain [AID142313, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
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22
[SID11114179]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
23
[SID56463261]
IC50 4.4Fluorescence-based biochemical high throughput dose response assay to identify molecules that bind r(CAG) RNA repeats [AID686959, Type: confirmatory]
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24
[SID56463261]
AC50_uM 4.459Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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25
[SID11111235]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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26
[SID56463261]
AC50_uM 5.568Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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27
[SID103187301]
EC50 6.2In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain [AID156359, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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28
[SID56463261]
AC50_uM 7.9MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5 [AID720591, Type: confirmatory]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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29
[SID103187301]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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30
[SID90340884]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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31
[SID103187301]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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32
[SID26752230]
Potency 12.5893qHTS assay for cell viability of the p53RE-bla HCT-116 cell line [AID743292, Type: confirmatory]
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33
[SID50104932]
Potency 12.5893Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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34
[SID90340884]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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35
[SID11114179]
Potency 14.1254qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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36
[SID26752230]
Potency 15.8489qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
37
[SID56463261]
Potency 18.8876qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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38
[SID56463261]
Potency 19.0115qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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39
[SID26752230]
Potency 19.9526qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
40
[SID11114179]
Potency 19.9526qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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41
[SID11114179]
Potency 19.9526qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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42
[SID124880245]
Potency 21.1142qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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43
[SID56463261]
Potency 21.1923qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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44
[SID124880245]
Potency 23.485Cytotoxicity counterscreen for NFkB agonists and antagonists [AID624476, Type: confirmatory]
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45
[SID144116848]
Potency 24.1489Inhibitors of USP1/UAF1: SAR in Primary Assay [AID651605, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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46
[SID90340884]
Potency 26.6795Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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47
[SID90340884]
Potency 26.6795qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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48
[SID50104932]
Potency 28.1838qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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49
[SID50104932]
Potency 28.1838qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2364, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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50
[SID11111235]
Potency 31.6228qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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