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Fluoxetine (CID 3386) - Compound BioActivity Data
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BioActivity Outcomes:
Active(201)
 
 
Inactive(192)
 
 
Inconclusive(116)
 
 
Unspecified(332)
 
 
Top Targets:
SLC6sbd SERT(57)
 
 
 
7TM GPCR Srx(30)
 
 
 
 
 
p450(24)
 
 
 
 
7TM GPCR Srsx(23)
 
 
 
 
SLC6sbd DAT1(16)
 
 
 
 
BioAssay Types:
Literature(447)
 
 
 
 
 
Confirmatory(182)
 
 
 
 
Screening(24)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
IC50(208)
 
 
 
 
 
Potency(196)
 
 
 
 
Ki(66)
 
 
 
 
Kd(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 741    Data Row: 841   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165728]
IC50 0.00051DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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2
[SID103165728]
Ki 0.00072Binding inhibition towards human serotonin transporter [AID254322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103165728]
Kd 0.00081Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT [AID204080, Type: Literature]
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4
[SID103165728]
Ki 0.0011Displacement of [125I]RTI55 from human recombinant SERT expressed in HEK293 cells [AID412739, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103165728]
Ki 0.0011Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells by scintillation counting [AID395334, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103165728]
Ki 0.002Binding affinity to human SERT [AID292944, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103165728]
Ki 0.0022Binding affinity to human SERT [AID306609, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103165728]
Ki 0.0022Binding affinity at human SERT [AID305407, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103165728]
Ki 0.0022Binding affinity to human SERT [AID300626, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID103165728]
IC50 0.0025Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cells [AID459375, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103165728]
EC50 0.0027Inhibition of human SERT-mediated serotonin reuptake in HEK293 cells [AID652440, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103165728]
Ki 0.0027Displacement of [3H]paroxetine from rat cortical 5HTT reuptake site [AID339528, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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13
[SID103165728]
Ki 0.0027Displacement of [3H]paroxetine from 5HT transporter in rat cortical membrane [AID422846, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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14
[SID103165728]
Ki 0.00272Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]paroxetine [AID204533, Type: Literature]
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15
[SID103165728]
Ki 0.0028Binding affinity to rat SERT [AID292943, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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16
[SID103165728]
Ki 0.0029Binding affinity at rat SERT [AID305406, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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17
[SID103165728]
Ki 0.0029Binding affinity to rat SERT [AID306608, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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18
[SID103165728]
Ki 0.0029Binding affinity to rat SERT [AID300625, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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19
[SID103165728]
IC50 0.0031Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells [AID504077, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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20
[SID103165728]
Ki 0.00317Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assay [AID205020, Type: other]
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21
[SID103165728]
Ki 0.0035Compound was evaluated for its binding affinity towards human serotonin transporter [AID204093, Type: Literature]
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22
[SID103165728]
Ki 0.0039Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membrane [AID388702, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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23
[SID103165728]
Ki 0.0039Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranes [AID268270, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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24
[SID103165728]
IC50 0.00501Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation counting [AID578419, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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25
[SID103165728]
IC50 0.00501Inhibition of serotonin reuptake at SERT expressed in HEK293 cells [AID611191, Type: Literature]
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26
[SID103165728]
IC50 0.0052Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation counting [AID550776, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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27
[SID103165728]
IC50 0.007Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cells [AID412742, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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28
[SID103165728]
IC50 0.0073Displacement of [3H]serotonin from human recombinant SERT expressed in HEK293 cells by scintillation counting [AID395503, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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29
[SID103165728]
Ki 0.0073Inhibition of [3H]5-HT uptake into rat synaptosomes by Serotonin transporter [AID204846, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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30
[SID103165728]
Ki 0.0073Inhibition of [3H]5-HT uptake by Serotonin transporter of rat midbrain or parietal synaptosomes [AID204698, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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31
[SID103165728]
Ki 0.0073Inhibition of high affinity re-uptake of [3H]5-HT (serotonin) into nerve ending synaptosomes [AID200773, Type: Literature]
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32
[SID103165728]
IC50 0.0081Compound was evaluated for its ability to antagonizing serotonin high affinity uptake was determined using [3H]5-HT on synaptosomes prepared from rat midbrain or parietal cortices. [AID181689, Type: Literature]
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33
[SID103165728]
Ki 0.0087Displacement of [3H]citalopram from Sprague-Dawley rat SERT [AID295325, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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34
[SID103165728]
IC50 0.0094Inhibition of [3H]hydroxytryptamine creatinine sulfate uptake at human SERT expressed in human JAR cells [AID431883, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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35
[SID103165728]
IC50 0.0094Inhibition of human SERT expressed in JAR cells [AID441347, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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36
[SID103165728]
IC50 0.0094Inhibition of seratonin uptake at human SERT expressed in JAR cells [AID446937, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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37
[SID103165728]
IC50 0.0094Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID459948, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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38
[SID103165728]
IC50 0.0094Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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39
[SID103165728]
IC50 0.0094Inhibition of SERT-mediated serotonin uptake in human JAR cells [AID483448, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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40
[SID103165728]
IC50 0.0094Inhibition of serotonin uptake at human SERT expressed in JAR cels [AID410151, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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41
[SID103165728]
IC50 0.0094Inhibition of 5HT uptake at human SERT expressed in human JAR cells [AID339394, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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42
[SID103165728]
IC50 0.0094Inhibition of human SERT expressed in JAR cells assessed as serotonin uptake [AID619832, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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43
[SID103165728]
IC50 0.01Inhibition of serotonin uptake at human SERT expressed in human JAR cells [AID352217, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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44
[SID103165728]
IC50 0.01Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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45
[SID103165728]
Ki 0.0108Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
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46
[SID103165728]
Ki 0.0122Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulation [AID596123, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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47
[SID103165728]
IC50 0.0126Displacement of [3H]paroxetine from SERT in rat cerebral cortex [AID504079, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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48
[SID103165728]
Ki 0.014Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes [AID186981, Type: Literature]
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49
[SID103165728]
IC50 0.015Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranes [AID196551, Type: other]
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50
[SID103165728]
IC50 0.015Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptake [AID200770, Type: Literature]
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