Fluorouracil (CID 3385) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(820)
 
 
Top Targets:
TS Pyrimidine..(5)
 
 
AAA 30(3)
 
 
COG2887(3)
 
 
DnaJ C(2)
 
 
Alpha TIF(1)
 
 
BioAssay Types:
Literature(670)
 
 
Confirmatory(33)
 
 
Screening(18)
 
 
BioActivity Types:
IC50(472)
 
 
Potency(19)
 
 
EC50(9)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 805    Data Row: 820   Total Pages: 17   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103507642]
IC50 1.1e-06Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay [AID603110, Type: Literature]
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2
[SID103507642]
IC50 1.7e-06Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay [AID603109, Type: Literature]
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3
[SID103507642]
IC50 2.7e-06Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID603108, Type: Literature]
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4
[SID103507642]
IC50 7.7e-06Cytotoxicity against human KB cells after 72 hrs by MTT assay [AID603209, Type: Literature]
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5
[SID103507642]
IC50 0.00446Cytotoxicity against human KB cells by MTT assay [AID353084, Type: Literature]
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6
[SID103507642]
GI50 0.01585Growth inhibition of human OVCAR-3 cells after 48 hrs by sulforhodamine B assay [AID538260, Type: Literature]
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7
[SID103507642]
IC50 0.016Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay [AID436373, Type: Literature]
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8
[SID103507642]
IC50 0.018Antiproliferative activity against human A431 cells after 48 hrs by MTT assay [AID436374, Type: Literature]
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9
[SID103507642]
IC50 0.02Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 24 hrs by liquid scintillation counting [AID589982, Type: Literature]Thymidylate synthase [gi:136614]
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10
[SID103507642]
GI50 0.0238Cytotoxicity against human SR cells after 48 hrs by SRB assay [AID644642, Type: Literature]
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11
[SID103507642]
GI50 0.02399Growth inhibition of human SR cells after 48 hrs by sulforhodamine B assay [AID538161, Type: Literature]
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12
[SID103507642]
IC50 0.03Antitumor activity against human MOLT4 cells after 24 hrs by MTT assay [AID475907, Type: Literature]
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13
[SID103507642]
GI50 0.04467Growth inhibition of human RPMI8266 cells after 48 hrs by sulforhodamine B assay [AID538160, Type: Literature]
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14
[SID103507642]
GI50 0.05129Growth inhibition of human MALME-3M cells after 48 hrs by sulforhodamine B assay [AID538252, Type: Literature]
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15
[SID103507642]
GI50 0.05248Growth inhibition of human HCC2998 cells after 48 hrs by sulforhodamine B assay [AID538239, Type: Literature]
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16
[SID103507642]
GI50 0.05623Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay [AID538168, Type: Literature]
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17
[SID103507642]
IC50 0.06Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxycytidine after preincubation for 24 hrs by liquid scintillation counting [AID589985, Type: Literature]Thymidylate synthase [gi:136614]
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18
[SID103507642]
GI50 0.0631Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay [AID538247, Type: Literature]
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19
[SID103507642]
CC50 0.07Cytotoxicity against human HL60 cells after 5 days by MTT assay [AID487439, Type: Literature]
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20
[SID103507642]
GI50 0.07244Growth inhibition of human Caki1 cells after 48 hrs by sulforhodamine B assay [AID538268, Type: Literature]
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21
[SID103507642]
GI50 0.07244Growth inhibition of human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay [AID538279, Type: Literature]
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22
[SID103507642]
GI50 0.07943Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay [AID538275, Type: Literature]
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23
[SID103507642]
ID50 0.1The compound was tested in vitro for antitumor activity(50% inhibition of tumor cell growth) against the P388/doxorubicin resistant murine cell lines after 72 hours [AID139457, Type: Literature]
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24
[SID103507642]
GI50 0.10965Growth inhibition of human HCT15 cells after 48 hrs by sulforhodamine B assay [AID538241, Type: Literature]
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25
[SID103507642]
IC50 0.12In vitro growth inhibition of L1210 cells 48 hours after administration of compound [AID98747, Type: Literature]
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26
[SID103507642]
IC50 0.125Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 48 hr [AID94110, Type: Literature]
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27
[SID103507642]
IC50 0.15Antitumor activity against colon carcinoma cell line (HT-29) [AID83946, Type: Literature]
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28
[SID103507642]
GI50 0.15849Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay [AID538238, Type: Literature]
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29
[SID103507642]
IC50 0.16Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID283688, Type: Literature]
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30
[SID103507642]
GI50 0.17783Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay [AID538242, Type: Literature]
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31
[SID103507642]
GI50 0.17783Growth inhibition of human NCI-H322M cells after 48 hrs by sulforhodamine B assay [AID538167, Type: Literature]
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32
[SID103507642]
ID50 0.18In vitro antitumor activity against mouse myeloid leukemia L1210 [AID96794, Type: Literature]
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33
[SID103507642]
IC50 0.18Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis [AID589873, Type: Literature]
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34
[SID103507642]
IC50 0.18Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine [AID589881, Type: Literature]
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35
[SID103507642]
GI50 0.18621Growth inhibition of human colon cancer cell after 48 hrs by sulforhodamine B assay [AID538288, Type: Literature]
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36
[SID103507642]
GI50 0.19055Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay [AID538162, Type: Literature]
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37
[SID103507642]
IC50 0.2Cytotoxicity against Vero cells [AID293618, Type: Literature]
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38
[SID103507642]
IC50 0.2Growth inhibition in L1210 mouse leukemia cells after 48 hr treatment [AID96473, Type: Literature]
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39
[SID103507642]
ID50 0.2In vitro antitumor activity (tumor cell growth inhibition) against MDAY-D2 cells [AID105451, Type: Literature]
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40
[SID103507642]
GI50 0.2138Growth inhibition of human KM12 cells after 48 hrs by sulforhodamine B assay [AID538243, Type: Literature]
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41
[SID103507642]
IC50 0.22Growth inhibition in L1210 mouse Leukemia cells for a treatment time of 24 hr [AID94108, Type: Literature]
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42
[SID103507642]
IC50 0.22In vitro growth inhibition of L1210 cells 24 hours after administration of compound [AID98746, Type: Literature]
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43
[SID103507642]
IC50 0.22Inhibition of thymidylate synthase in mouse L1210 cells assessed as inhibition of tritium release from [5-3H]deoxyuridine after preincubation for 4 hrs by liquid scintillation counting [AID589981, Type: Literature]Thymidylate synthase [gi:136614]
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44
[SID103507642]
GI50 0.22909Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay [AID538240, Type: Literature]
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45
[SID103507642]
GI50 0.22909Growth inhibition of human SF295 cells after 48 hrs by sulforhodamine B assay [AID538246, Type: Literature]
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46
[SID103507642]
EC50 0.23Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay [AID334278, Type: Literature]
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47
[SID103507642]
GI50 0.24547Growth inhibition of human LOXIMVI cells after 48 hrs by sulforhodamine B assay [AID538251, Type: Literature]
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48
[SID103507642]
IC50 0.28Cytostatic activity against mouse L1210 cells [AID310284, Type: Literature]
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49
[SID103507642]
IC50 0.28Concentration required to inhibit 50% of cell growth on murine L1210 cells. [AID224730, Type: Literature]
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50
[SID103507642]
GI50 0.29512Growth inhibition of human ACHN cells after 48 hrs by sulforhodamine B assay [AID538267, Type: Literature]
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