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Salicylic Acid (CID 338) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(1016)
 
 
Inconclusive(33)
 
 
Unspecified(310)
 
 
Top Targets:
7TM GPCR Srx(40)
 
 
 
 
7TM GPCR Srsx(37)
 
 
 
NR LBD ER(26)
 
 
 
 
NR LBD PPAR(24)
 
 
 
NR LBD AR(22)
 
 
 
 
BioAssay Types:
Screening(528)
 
 
 
 
Confirmatory(427)
 
 
 
 
Literature(193)
 
 
 
 
 
Summary(63)
 
 
BioActivity Types:
Potency(414)
 
 
 
 
IC50(170)
 
 
 
 
Ki(25)
 
 
 
EC50(10)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1127    Data Row: 1389   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164944]
IC50 0.2Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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2
[SID103164944]
Ki 7.1Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay [AID342476, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103164944]
Ki 7.12Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay [AID331292, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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4
[SID103164944]
Ki 7.2Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay [AID331293, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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5
[SID103164944]
Ki 8.8Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay [AID342484, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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6
[SID103164944]
Ki 9.9Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay [AID342475, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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7
[SID103164944]
Ki 9.92Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay [AID331291, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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8
[SID103164944]
Ki 11.1Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay [AID342478, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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9
[SID103164944]
Ki 11.9Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay [AID342481, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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10
[SID103164944]
Ki 43.6516Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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11
[SID103164944]
Ki 49.8Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay [AID342485, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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12
[SID8139912]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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13
[SID8139912]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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14
[SID8139912]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors with Validation compound Set [AID588506, Type: screening]
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15
[SID8139912]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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16
[SID8139912]
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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17
[SID103164944]
Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as ompX upregulation after 60 mins relative to control [AID369250, Type: Literature]
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18
[SID103164944]
Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as increase in beta-galactosidase activity after 60 mins relative to control [AID369251, Type: Literature]
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19
[SID103164944]
Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as ompX upregulation after 60 mins relative to control [AID369252, Type: Literature]
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20
[SID103164944]
Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as increase in beta-galactosidase activity after 60 mins relative to control [AID369253, Type: Literature]
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21
[SID103164944]
Induction of ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as total RNA content after 30 mins by RT-PCR [AID369255, Type: Literature]
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22
[SID103164944]
Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604020, Type: Literature]
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23
[SID103164944]
Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
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24
[SID103164944]
Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
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25
[SID103164944]
Inhibition of TNF-alpha-induced NF-kappaB activation in human HCT116 cells at 1 mM after 6 hrs by luciferase reporter gene assay [AID639952, Type: Literature]
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26
[SID103164944]
Inhibition of NF-kappaB-mediated iNOS protein expression in LPS-stimulated mouse RAW264.7 cells at 5 mM by Western blot analysis [AID639955, Type: Literature]
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27
[SID103164944]
Inhibition of NF-kappaB-mediated iNOS protein expression in LPS-stimulated mouse RAW264.7 cells at 2 to 4 mM by Western blot analysis [AID639957, Type: Literature]
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28
[SID103164944]
Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL-8 release at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA [AID732288, Type: Literature]
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29
[SID103164944]
Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced IL-1beta release at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA [AID732289, Type: Literature]
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30
[SID103164944]
Antiinflammatory activity in human macrophages assessed as inhibition of LPS-induced TNFalpha release at 10 uM preincubated for 30 mins before LPS-challenge measured after 24 hrs post challenge by ELISA [AID732290, Type: Literature]
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31
[SID103164944]
Ki 1.8Inhibitory activity against binding of [125I]IMSB to amyloid beta in brain [AID38551, Type: Literature]
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32
[SID103164944]
Ki 67Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay [AID342486, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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33
[SID103164944]
Ki 78.7Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay [AID342483, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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34
[SID103164944]
Km 81.2TP_TRANSPORTER: uptake in Oat2-expressing LLC PK1 cells [AID678818, Type: other]Solute carrier family 22 member 7 [gi:81871841]
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35
[SID103164944]
Ki 82.1Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay [AID342482, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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36
[SID103164944]
Km 88.8TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681575, Type: other]Solute carrier family 22 member 7 [gi:81871841]
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37
[SID103164944]
IC50 100Inhibition of mushroom tyrosinase after 10 mins [AID566711, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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38
[SID103164944]
Ki 144.544Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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39
[SID103164944]
EC50 250Plaque growth inhibition [AID666145, Type: Literature]Polymerase acidic protein [gi:158931133]
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40
[SID103164944]
IC50 260GRAC: human ASIC3 blocker [AID540700, Type: other]Acid-sensing ion channel 3 [gi:82582992]
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41
[SID103164944]
IC50 280TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells [AID681331, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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42
[SID103164944]
Ki 324Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay [AID607497, Type: Literature]Carbonic anhydrase [gi:123910379]
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43
[SID103164944]
Ki 341TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID681340, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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44
[SID103164944]
Ki 355Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay [AID342480, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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45
[SID103164944]
IC50 560Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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46
[SID103164944]
Ki 620Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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47
[SID103164944]
Ki 678Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay [AID342479, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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48
[SID103164944]
IC50 680Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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49
[SID103164944]
Ki 740Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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50
[SID103164944]
Ki 885Inhibition of human carbonic anhydrase 3 by stopped-flow CO2 hydration assay [AID342477, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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