Sodium Azide (CID 33557) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(11)
 
 
Inactive(142)
 
 
Inconclusive(10)
 
 
Unspecified(29)
 
 
Top Targets:
alpha CA I II..(6)
 
 
 
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
P53(3)
 
 
NR LBD ROR li..(3)
 
 
 
BioAssay Types:
Confirmatory(141)
 
 
 
 
Literature(37)
 
 
 
 
BioActivity Types:
Potency(105)
 
 
 
 
Ki(17)
 
 
 
IC50(6)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 184    Data Row: 192   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103329735]
IC50 1.2Inhibition of full-length recombinant HIV1 integrase [AID569226, Type: Literature]
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2
[SID103329735]
Ki 1.2Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598726, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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3
[SID103329735]
Ki 1.2Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 [AID587130, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103329735]
Ki 1.2Inhibition of human carbonic anhydrase 1 by Lineweaver-Burk curves [AID552171, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID17390030]
Potency 2.5119Cell Viability - LYMP2-005 [AID967, Type: confirmatory]
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6
[SID103329735]
Ki 5Inhibition of human carbonic anhydrase 9 by Lineweaver-Burk curves [AID552168, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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7
[SID17390030]
Potency 17.7828qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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8
[SID17390030]
Potency 17.7828qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID48413250]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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10
[SID48415472]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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11
[SID103329735]
 Increase in lactate production in primary human osteoblasts at 1 mM after 1 hr by ELISA [AID278886, Type: Literature]
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12
[SID103329735]
 Increase in lactate production in MG63 cells at 1mM after 1 hr by ELISA [AID278887, Type: Literature]
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13
[SID103329735]
IC50 257Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 200 uM dopamine as substrate preincubated for 30 mins before substrate addition [AID628708, Type: Literature]
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14
[SID103329735]
IC50 263Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 100 uM epinephrine as substrate preincubated for 30 mins before substrate addition [AID628706, Type: Literature]
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15
[SID103329735]
IC50 279Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 300 uM L-dopa as substrate preincubated for 30 mins before substrate addition [AID628709, Type: Literature]
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16
[SID103329735]
Ki 300Inhibition of human carbonic anhydrase 5 by Lineweaver-Burk curves [AID552169, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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17
[SID103329735]
IC50 329Inhibition of laccase in Cryptococcus neoformans var. grubii assessed as production of dopachrome using 100 uM epinephrine as substrate preincubated for 30 mins before substrate addition [AID628707, Type: Literature]
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18
[SID103329735]
Ki 350Inhibition of Streptococcus pneumoniae beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay [AID552785, Type: Literature]
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19
[SID103329735]
Ki 490Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay [AID677270, Type: Literature]
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20
[SID103329735]
Ki 750Inhibition of Salmonella Typhimurium carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598732, Type: Literature]
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21
[SID103329735]
Ki 830Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5 [AID587132, Type: Literature]
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22
[SID103329735]
Ki 830Inhibition of Helicobacter pylori alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay [AID677271, Type: Literature]
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23
[SID103329735]
Ki 920Inhibition of Salmonella Typhimurium carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598731, Type: Literature]
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24
[SID103329735]
Ki 1500Inhibition of human carbonic anhydrase 2 by Lineweaver-Burk curves [AID552172, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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25
[SID103329735]
Ki 1500Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 [AID587131, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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26
[SID103329735]
Ki 1510Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3 [AID598728, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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27
[SID103329735]
Ki 1563Inhibition of Dicentrarchus labrax alpha-carbonic anhydrase by Lineweaver-Burk curves [AID552170, Type: Literature]
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28
[SID103329735]
Ki 27800Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay [AID647373, Type: Literature]
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29
[SID103329735]
IC50 46000Inhibition of HIV-1 integrase by colorimetry [AID684672, Type: Literature]
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30
[SID103329735]
Ki 65100Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curves [AID552173, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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31
[SID17390030]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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32
[SID103329735]
 Inhibition of full-length recombinant HIV1 integrase at 5 ug/ml [AID569225, Type: Literature]
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33
[SID103329735]
 Protection against 30 mins photoirradiation-induced damage in rat liver mitochondria assessed as reduction of lipid hydroperoxide formation at 10 mM [AID323190, Type: Literature]
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34
[SID103329735]
 Protection against 30 mins photoirradiation-induced lipid peroxidation damage in rat liver mitochondria assessed as prevention of TBARS formation at 10 mM [AID323191, Type: Literature]
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35
[SID103329735]
 Mutagenic activity in Salmonella typhimurium TA100 assessed as increase in number of revertants at 5 ug/plate by Ames test absence of S9 fraction (Rvb=108+/-5) [AID465486, Type: Literature]
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36
[SID103329735]
 Cytotoxicity against human HEK293 cells at 30 mM after 48 hrs by neutral red assay [AID471636, Type: Literature]
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37
[SID103329735]
 Induction of mutagenicity in Salmonella serovar Typhimurium TA 100 assessed as number of revertant colonies at 5 ug by Ames assay [AID533734, Type: Literature]
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38
[SID103329735]
 Compound was tested for its ability to inhibit DNA strand scission induced by resveratrol and Cu2+, at concentration 50 mM [AID69151, Type: Literature]
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39
[SID103329735]
 Increase in lactate production in primary human osteoblasts by ELISA relative to control [AID278870, Type: Literature]
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40
[SID103329735]
 Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs below 1 mM [AID278883, Type: Literature]
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41
[SID103329735]
 Mutagenic activity in Salmonella typhimurium TA 100 assessed as increase in revertants at 5 ug/plate after 48 hrs by Ames test relative to control [AID661625, Type: Literature]
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42
[SID17390030]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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43
[SID17390030]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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44
[SID17390030]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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45
[SID17390030]
Potency 25.1189qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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46
[SID17390030]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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47
[SID17390030]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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48
[SID17390030]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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49
[SID17390030]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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50
[SID17390030]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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