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2-n-octyl-4-isothiazolin-3-one (CID 33528) - Compound BioActivity Data
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BioActivity Outcomes:
Active(340)
 
 
Inactive(481)
 
 
Inconclusive(152)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(26)
 
 
 
7TM GPCR Srx(21)
 
 
 
 
NR LBD ER(18)
 
 
 
 
NR LBD AR(18)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
BioAssay Types:
Confirmatory(436)
 
 
 
 
 
Screening(308)
 
 
 
 
Summary(48)
 
 
 
 
Literature(6)
 
 
 
BioActivity Types:
Potency(401)
 
 
 
 
 
IC50(24)
 
 
 
 
 
EC50(5)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 638    Data Row: 984   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389310]
Potency 0.4467qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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2
[SID144210883]
Potency-Replicate_1 0.4535qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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3
[SID17389310]
Potency 0.631VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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4
[SID17389310]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID17389310]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID85146933]
AC50_uM 0.649HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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7
[SID144210883]
Potency-Replicate_1 0.7188qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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8
[SID85146933]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID85146933]
AC50_uM 0.871Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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10
[SID144208657]
Potency-Replicate_1 0.8727qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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11
[SID85146933]
EC50_MICROM 0.912Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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12
[SID144210883]
Potency-Replicate_1 1.0153qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID144210883]
Potency-Replicate_1 1.149qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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14
[SID85146933]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID85146933]
EC50_MICROM 1.226Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 based on MLPCN hits [AID2742, Type: confirmatory]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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16
[SID85146933]
IC50 1.29High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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17
[SID144208657]
Potency-Replicate_1 1.3831qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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18
[SID144208657]
Potency-Replicate_1 1.5519qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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19
[SID144210883]
Potency-Replicate_1 1.821qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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20
[SID144208657]
Potency-Replicate_1 1.9537qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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21
[SID17389310]
Potency 1.9953Cell Viability - LYMP2-001 [AID921, Type: confirmatory]
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22
[SID144210883]
Potency-Replicate_1 2.0432qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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23
[SID85146933]
IC50 2.06A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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24
[SID144208657]
Potency-Replicate_1 2.1734qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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25
[SID17389310]
Potency 2.5119Cell Viability - LYMP2-022 [AID987, Type: confirmatory]
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26
[SID17389310]
Potency 2.5119Cell Viability - LYMP2-024 [AID988, Type: confirmatory]
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27
[SID17389310]
Potency 2.5119Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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28
[SID17389310]
Potency 2.5119Cell Viability - LYMP2-007 [AID979, Type: confirmatory]
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29
[SID144208657]
Potency-Replicate_1 3.07qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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30
[SID17389310]
Potency 3.1623Cell Viability - LYMP2-015 [AID971, Type: confirmatory]
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31
[SID85146933]
Potency 3.5481Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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32
[SID144210883]
Potency-Replicate_1 3.6026qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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33
[SID144208657]
Ratio Potency (uM) 3.68004qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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34
[SID85146933]
IC50_Mean 3.75Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504765, Type: confirmatory]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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35
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-017 [AID972, Type: confirmatory]
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36
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-005 [AID967, Type: confirmatory]
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37
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-020 [AID986, Type: confirmatory]
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38
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-019 [AID973, Type: confirmatory]
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39
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-021 [AID974, Type: confirmatory]
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40
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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41
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-004 [AID966, Type: confirmatory]
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42
[SID17389310]
Potency 3.9811Cell Viability - LYMP2-026 [AID989, Type: confirmatory]
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43
[SID144208657]
Potency-Replicate_1 4.3737qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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44
[SID144210883]
Potency-Replicate_1 4.5743qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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45
[SID85146933]
Potency 4.7444qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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46
[SID144208657]
Potency-Replicate_1 4.8657qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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47
[SID144208657]
Potency-Replicate_1 4.8657qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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48
[SID17389310]
Potency 5.0119MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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49
[SID17389310]
Potency 5.0119Cell Viability - LYMP2-018 [AID985, Type: confirmatory]
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50
[SID17389310]
Potency 5.0119Cell Viability - LYMP2-009 [AID968, Type: confirmatory]
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