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2-n-octyl-4-isothiazolin-3-one (CID 33528) - Compound BioActivity Data
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BioActivity Outcomes:
Active(340)
 
 
Inactive(494)
 
 
Inconclusive(147)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(26)
 
 
 
7TM GPCR Srx(21)
 
 
 
 
NR LBD AR(18)
 
 
 
 
NR LBD ER(18)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
BioAssay Types:
Confirmatory(436)
 
 
 
 
 
Screening(309)
 
 
 
 
Summary(48)
 
 
 
 
Literature(13)
 
 
 
BioActivity Types:
Potency(402)
 
 
 
 
 
IC50(24)
 
 
 
 
 
EC50(5)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 639    Data Row: 992   Total Pages: 50   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389310]
Potency 0.4467qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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2
[SID144210883]
Potency-Replicate_1 0.4535qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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3
[SID17389310]
Potency 0.631VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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4
[SID17389310]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID17389310]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID85146933]
AC50_uM 0.649HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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7
[SID144210883]
Potency-Replicate_1 0.7188qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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8
[SID85146933]
Potency 0.7308qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID85146933]
AC50_uM 0.871Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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10
[SID144208657]
Potency-Replicate_1 0.8727qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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11
[SID85146933]
EC50_MICROM 0.912Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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12
[SID144210883]
Potency-Replicate_1 1.0153qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID144210883]
Potency-Replicate_1 1.149qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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14
[SID85146933]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID85146933]
EC50_MICROM 1.226Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically MEP2 based on MLPCN hits [AID2742, Type: confirmatory]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
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16
[SID85146933]
IC50 1.29High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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17
[SID144208657]
Potency-Replicate_1 1.3831qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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18
[SID144210883]
Potency-Replicate_1 1.821qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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19
[SID144208657]
Potency-Replicate_1 1.9537qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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20
[SID17389310]
Potency 1.9953Cell Viability - LYMP2-001 [AID921, Type: confirmatory]
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