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BioActivity Data for Compound 5-chloro-2-methyl-4-isothiazolin-3-one (CID 33344)

BioActivity Outcomes:
Active(8)
 
 
Inactive(232)
 
 
Inconclusive(17)
 
 
Unspecified(1)
 
 
Top Targets:
NR LBD AR(14)
 
 
 
 
NR LBD ER(14)
 
 
NR LBD PPAR(10)
 
 
NR LBD GR(8)
 
 
 
NR LBD TR(6)
 
 
 
 
BioAssay Types:
Confirmatory(150)
 
 
 
 
Literature(62)
 
 
 
Summary(44)
 
 
 
 
Screening(2)
 
 
BioAssay Categories:
Biochemical(1)
 
 
Toxicity(12)
 
 
 
BioActivity Types:
Potency(185)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 258   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210519]
Potency-Replicate_1 19.3312qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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2
[SID144210519]
Potency-Replicate_1 21.6899qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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3
[SID144206242]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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4
[SID144210519]
Ratio Potency (uM) 47.1227qHTS assay to identify small molecule agonists of the AP-1 signaling pathway: Summary [AID1159528, Type: summary]v-jun sarcoma virus 17 oncogene homolog (avian) [Homo sapiens] [gi:119627033]
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5
[SID144210519]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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6
[SID144210519]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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7
[SID144210519]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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8
[SID144210519]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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9
[SID50125776]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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10
[SID144210519]
Potency-Replicate_1 0.1548qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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11
[SID144206242]
Potency-Replicate_1 14.9601qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
12
[SID144210519]
Potency-Replicate_1 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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13
[SID144206242]
Potency-Replicate_1 29.8493qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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14
[SID144210519]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
15
[SID144206242]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144210519]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
17
[SID144210519]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway [AID1159516, Type: confirmatory]activating transcription factor 6 [Homo sapiens] [gi:119611100]
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18
[SID144210519]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway: Summary [AID1159519, Type: summary]activating transcription factor 6 [Homo sapiens] [gi:119611100]
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19
[SID144210519]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the NFkB signaling pathway: Summary [AID1159518, Type: summary]nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a [Homo sapiens] [gi:119626539]
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20
[SID144210519]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the NFkB signaling pathway [AID1159509, Type: confirmatory]nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a [Homo sapiens] [gi:119626539]
View