Glutamic Acid (CID 33032) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(161)
 
 
Inactive(170)
 
 
Inconclusive(16)
 
 
Unspecified(68)
 
 
Top Targets:
PBPe(10)
 
 
 
p450(10)
 
 
 
 
7tm 3(9)
 
 
SDF(9)
 
 
 
PBP1 mGluR gr..(8)
 
 
BioAssay Types:
Literature(225)
 
 
 
 
 
Confirmatory(168)
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
EC50(96)
 
 
 
Ki(64)
 
 
 
IC50(22)
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 373    Data Row: 415   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103699331]
IC50 0.0057Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8 [AID242207, Type: Literature]Metabotropic glutamate receptor 8 [gi:12644040]
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2
[SID103699331]
EC50 0.022Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse [AID107403, Type: Literature]
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3
[SID103699331]
Ki 0.051Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells [AID339909, Type: Literature]Excitatory amino acid transporter 3 [gi:1352332]
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4
[SID103699331]
Ki 0.063Binding affinity towards Ionotropic glutamate receptor kainate by displacement of [3H]-kainic acid radioligand [AID93739, Type: Literature]
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5
[SID103699331]
IC50 0.069Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membrane [AID355928, Type: Literature]
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6
[SID103699331]
Ki 0.07Displacement of [3H]kainic acid from rat KA receptor expressed in BHK cells [AID298027, Type: Literature]
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7
[SID103699331]
Ki 0.08Displacement of [3H]AMPA from rat AMPA receptor expressed in BHK cells [AID298028, Type: Literature]
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8
[SID103699331]
Ki 0.092Displacement of [3H]kainic acid from kainate receptor in rat brain membranes [AID411488, Type: Literature]
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9
[SID103699331]
EC50 0.12Compound was evaluated for the inhibition of [3H]MK-801 binding at N-methyl-D-aspartate glutamate receptor [AID144321, Type: Literature]
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10
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat recombinant iGluR5 [AID339927, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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11
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat recombinant iGluR5 [AID339927, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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12
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478467, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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13
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478467, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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14
[SID103699331]
Ki 0.169Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells [AID391442, Type: Literature]Glutamate receptor 1 [gi:97536283]
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15
[SID103699331]
IC50 0.17In vitro binding affinity against synaptic membrane from rat brain using [3H](S)-Glu as the radioligand [AID179581, Type: Literature]
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16
[SID103699331]
Ki 0.17Displacement of [3H]AMPA from AMPA receptor in rat brain membranes [AID411487, Type: Literature]
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17
[SID103699331]
IC50 0.171Inhibition of N-methyl-D-aspartate glutamate receptor by using [3H]CPP as a radioligand from the rat cortical membranes. [AID144621, Type: Literature]
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18
[SID103699331]
IC50 0.172Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor [AID144612, Type: Literature]
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19
[SID103699331]
Ki 0.2Binding affinity towards NMDA receptor by displacement of [3H]CGP-39653 radioligand. [AID145324, Type: Literature]
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20
[SID103699331]
Ki 0.2Displacement of [3H]CGP39653 from NMDA receptor in rat cortical synaptosome [AID339879, Type: Literature]
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21
[SID103699331]
Ki 0.2Displacement of [3H]CGP-39653 from rat NMDA receptor expressed in BHK cells [AID298026, Type: Literature]
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22
[SID103699331]
Ki 0.2Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membranes [AID478464, Type: Literature]
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23
[SID103699331]
Ki 0.249Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR3 expressed in Sf9 cells [AID391444, Type: Literature]Glutamate receptor 3 [gi:121434]
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24
[SID103699331]
Ki 0.25Displacement of [3H]quisqualate from mGluR1 receptor expressed in BHK cells [AID298022, Type: Literature]Metabotropic glutamate receptor 1 [gi:311033443]
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25
[SID103699331]
IC50 0.27In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand [AID168917, Type: Literature]
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26
[SID103699331]
Ki 0.28Displacement of [3H]AMPA from rat iGluR2 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478466, Type: Literature]Glutamate receptor 2 [gi:3287964]
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27
[SID103699331]
Ki 0.282Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cells [AID391443, Type: Literature]Glutamate receptor 2 [gi:3287964]
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28
[SID103699331]
Ki 0.29Displacement of [3H]CGP39653 from NMDA receptor in rat brain membranes [AID411486, Type: Literature]
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29
[SID103699331]
EC50 0.29The effective concentration for 50% glutamate response was measured on Group II Metabotropic glutamate receptor [AID75021, Type: Literature]
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30
[SID103699331]
Ki 0.33Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478468, Type: Literature]Glutamate receptor ionotropic, kainate 2 [gi:3287965]
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31
[SID103699331]
Ki 0.331Displacement of [3H]SYM2081 from rat recombinant iGluR6 [AID339928, Type: Literature]Glutamate receptor ionotropic, kainate 2 [gi:3287965]
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32
[SID103699331]
Ki 0.332Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cells [AID391447, Type: Literature]Glutamate receptor ionotropic, kainate 2 [gi:3287965]
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33
[SID103699331]
IC50 0.34Displacement of [3H]AMPA from AMPA receptor in rat cortical synaptosome [AID339877, Type: Literature]
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34
[SID103699331]
IC50 0.34Displacement of [3H]AMPA from AMPA receptor in Sprague-Dawley rat brain membranes [AID478462, Type: Literature]
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35
[SID103699331]
Ki 0.354Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR4 expressed in Sf9 cells [AID391445, Type: Literature]Glutamate receptor 4 [gi:121435]
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36
[SID103699331]
IC50 0.38Displacement of [3H]KA from KA receptor in Sprague-Dawley rat brain membranes [AID478463, Type: Literature]
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37
[SID103699331]
IC50 0.38Displacement of [3H]KAIN from KA receptor in rat cortical synaptosome [AID339878, Type: Literature]
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38
[SID103699331]
Ki 0.39Binding affinity to mGluR5 receptor expressed in BHK cells [AID298024, Type: Literature]Metabotropic glutamate receptor 5 [gi:1709020]
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39
[SID103699331]
Ki 0.39Binding affinity to mGluR5 receptor expressed in BHK cells [AID298024, Type: Literature]Metabotropic glutamate receptor 5 [gi:1709020]
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40
[SID103699331]
EC50 0.4Effective concentration against NR1/NR2D receptor [AID146064, Type: other]
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41
[SID103699331]
EC50 0.45Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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42
[SID103699331]
EC50 0.45Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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43
[SID103699331]
EC50 0.45Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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44
[SID103699331]
Ki 0.49Displacement of [3H]SYM2081 from rat iGluR7 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478469, Type: Literature]Glutamate receptor ionotropic, kainate 3 [gi:1169965]
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45
[SID103699331]
Ki 0.494Displacement of [3H]SYM2081 from rat recombinant iGluR7 [AID339929, Type: Literature]Glutamate receptor ionotropic, kainate 3 [gi:1169965]
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46
[SID103699331]
IC50 0.5In vitro binding affinity against synaptic membrane from rat brain using [3H]-AMPA as the radioligand [AID168915, Type: Literature]
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47
[SID103699331]
Ki 0.57Displacement of [3H]Quisqualate from human mGluR1A receptor expressed in BHK cells [AID411489, Type: Literature]Metabotropic glutamate receptor 1 [gi:311033443]
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48
[SID103699331]
EC50 0.61Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor [AID221527, Type: Literature]
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49
[SID103699331]
IC50 0.613Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA [AID255079, Type: Literature]Adenosine receptor A [gi:1351831]
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50
[SID103699331]
IC50 0.613Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA [AID255079, Type: Literature]Adenosine receptor A [gi:1351831]
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