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Glutamic Acid (CID 33032) - Compound BioActivity Data
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BioActivity Outcomes:
Active(187)
 
 
Inactive(251)
 
 
Inconclusive(22)
 
 
Unspecified(80)
 
 
Top Targets:
PBPe(12)
 
 
 
p450(11)
 
 
 
7tm 3(9)
 
 
SDF(9)
 
 
PBP1 iGluR NM..(9)
 
 
 
BioAssay Types:
Literature(257)
 
 
 
 
 
Confirmatory(240)
 
 
 
 
Summary(15)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(230)
 
 
 
 
EC50(97)
 
 
 
Ki(79)
 
 
 
IC50(30)
 
 
 
Kd(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 463    Data Row: 540   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103699331]
IC50 0.0057Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8 [AID242207, Type: Literature]Metabotropic glutamate receptor 8 [gi:12644040]
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2
[SID103699331]
EC50 0.022Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse [AID107403, Type: Literature]
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3
[SID103699331]
Ki 0.051Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells [AID339909, Type: Literature]Excitatory amino acid transporter 3 [gi:1352332]
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4
[SID103699331]
Ki 0.063Binding affinity towards Ionotropic glutamate receptor kainate by displacement of [3H]-kainic acid radioligand [AID93739, Type: Literature]
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5
[SID103699331]
IC50 0.069Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membrane [AID355928, Type: Literature]
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6
[SID103699331]
Ki 0.07Displacement of [3H]kainic acid from rat KA receptor expressed in BHK cells [AID298027, Type: Literature]
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7
[SID103699331]
IC50 0.07Antagonist activity at NMDA receptor (unknwon origin) [AID711557, Type: Literature]
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8
[SID103699331]
Ki 0.08Displacement of [3H]AMPA from rat AMPA receptor expressed in BHK cells [AID298028, Type: Literature]
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9
[SID103699331]
Ki 0.092Displacement of [3H]kainic acid from kainate receptor in rat brain membranes [AID411488, Type: Literature]
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10
[SID103699331]
EC50 0.12Compound was evaluated for the inhibition of [3H]MK-801 binding at N-methyl-D-aspartate glutamate receptor [AID144321, Type: Literature]
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11
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat recombinant iGluR5 [AID339927, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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12
[SID103699331]
Ki 0.14Displacement of [3H]SYM2081 from rat iGluR5 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting [AID478467, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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13
[SID103699331]
Ki 0.14Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillation counting [AID723874, Type: Literature]Glutamate receptor ionotropic, kainate 1 [gi:1169962]
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14
[SID103699331]
Ki 0.169Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells [AID391442, Type: Literature]Glutamate receptor 1 [gi:97536283]
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15
[SID103699331]
Ki 0.17Displacement of [3H]AMPA from AMPA receptor in rat brain membranes [AID411487, Type: Literature]
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16
[SID103699331]
IC50 0.17In vitro binding affinity against synaptic membrane from rat brain using [3H](S)-Glu as the radioligand [AID179581, Type: Literature]
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17
[SID103699331]
IC50 0.171Inhibition of N-methyl-D-aspartate glutamate receptor by using [3H]CPP as a radioligand from the rat cortical membranes. [AID144621, Type: Literature]
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18
[SID103699331]
IC50 0.172Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor [AID144612, Type: Literature]
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19
[SID103699331]
Ki 0.2Binding affinity towards NMDA receptor by displacement of [3H]CGP-39653 radioligand. [AID145324, Type: Literature]
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20
[SID103699331]
Ki 0.2Displacement of [3H]CGP39653 from NMDA receptor in rat brain cortex after 60 mins by Packard TopCount microplate scintillator counting [AID723876, Type: Literature]
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