STK393606 (CID 3245059) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(8)
 
 
Inactive(688)
 
 
Inconclusive(11)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(10)
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(486)
 
 
 
 
 
Confirmatory(199)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(136)
 
 
 
 
 
IC50(45)
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 708    Data Row: 714   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99343744]
 Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2407, Type: summary]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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2
[SID99343744]
 Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2407, Type: summary]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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3
[SID99343744]
 Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2407, Type: summary]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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4
[SID4251360]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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5
[SID4251360]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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6
[SID4251360]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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7
[SID87550717]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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8
[SID87550717]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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9
[SID87550717]
Potency 0.1413Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2429, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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10
[SID4251360]
Potency 0.2239qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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11
[SID4251360]
Potency 0.2239qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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12
[SID4251360]
Potency 0.2239qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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13
[SID4251360]
 Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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14
[SID87550717]
 Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2427, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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15
[SID87550717]
 Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2427, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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16
[SID87550717]
 Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID2427, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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17
[SID4251360]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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18
[SID4251360]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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19
[SID4251360]
 Fluorescent Polarization-based biochemical high throughput orthogonal assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651607, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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20
[SID4251360]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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21
[SID4251360]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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22
[SID4251360]
 Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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23
[SID4251360]
 Plasma Stability Human - 2 [AID624420, Type: other]
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24
[SID4251360]
 Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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25
[SID4251360]
 Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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26
[SID4251360]
 Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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27
[SID4251360]
Potency 22.3872qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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28
[SID87550717]
Potency 39.8107qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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29
[SID87550717]
Potency 39.8107qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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30
[SID4251360]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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31
[SID4251360]
IC50 100Chemical Antagonists IAP-family anti-apoptotic proteins [AID1018, Type: confirmatory]X-linked inhibitor of apoptosis [Homo sapiens] [gi:8744934]
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32
[SID4251360]
IC50 100Counter Screen using XIAP-Bir3 for Chemical Antagonists of Bir1/2 domains of IAP-family anti-apoptotic proteins [AID1513, Type: confirmatory]X-linked inhibitor of apoptosis [Homo sapiens] [gi:8744934]
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33
[SID4251360]
 High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary Screen [AID1066, Type: screening]acetyl-CoA acetyltransferase/HMG-CoA reductase [Enterococcus faecalis] [gi:9937384]
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34
[SID4251360]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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35
[SID4251360]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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36
[SID4251360]
Potency qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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37
[SID87550717]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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38
[SID4251360]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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39
[SID4251360]
 Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase [AID1556, Type: screening]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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40
[SID4251360]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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41
[SID4251360]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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42
[SID4251360]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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43
[SID4251360]
 Primary cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 binding [AID861, Type: screening]toll-like receptor 4 [Homo sapiens] [gi:55662034]
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44
[SID4251360]
 QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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45
[SID4251360]
 Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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46
[SID4251360]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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47
[SID4251360]
 Primary HTS assay for chemical inhibitors of TNF alpha stimulated E-Selectin expression [AID1246, Type: screening]selectin E (endothelial adhesion molecule 1) [Homo sapiens] [gi:56417702]
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48
[SID4251360]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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49
[SID4251360]
 Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain A, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Dom [gi:67463988]
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50
[SID4251360]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) [AID1706, Type: screening]3C-like protease [Infectious bronchitis virus] [gi:73745819]
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