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F0646-3456 (CID 3241407) - Compound BioActivity Data
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BioActivity Outcomes:
Active(40)
 
 
Inactive(777)
 
 
Inconclusive(52)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(21)
 
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(561)
 
 
 
 
Confirmatory(274)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(56)
 
 
 
EC50(18)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 797    Data Row: 870   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4247173]
EC50 2.116Dose response cell-based assay to measure STAT1 activation [AID1397, Type: confirmatory]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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2
[SID4247173]
Potency 2.5119qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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3
[SID4247173]
Potency 2.8184qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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4
[SID4247173]
EC50 3.371Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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5
[SID4247173]
Potency 4.7755qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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6
[SID4247173]
EC50 6.641Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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7
[SID4247173]
EC50 14.3uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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8
[SID4247173]
IC50_Mean 14.8Dose Response confirmation of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay [AID504728, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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9
[SID4247173]
IC50 14.851HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction [AID2485, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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10
[SID4247173]
Potency 15.8489qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID4247173]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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12
[SID4247173]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID4247173]
EC50 17.83Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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14
[SID4247173]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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15
[SID4247173]
Counterscreen for activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM): Luminescence-based cell-based high throughput screening assay to identify non-selective compounds using the VP16 reporter assay [AID686939, Type: screening]
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16
[SID4247173]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
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17
[SID4247173]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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18
[SID4247173]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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19
[SID4247173]
Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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20
[SID4247173]
Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1 [AID1304, Type: screening]neuropeptide Y receptor type 1 [Homo sapiens] [gi:4505445]
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