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SMR000023416 (CID 3237838) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(776)
 
 
Inconclusive(20)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(19)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
PTPc(9)
 
 
BioAssay Types:
Screening(533)
 
 
 
 
 
Confirmatory(253)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(164)
 
 
 
 
 
IC50(52)
 
 
EC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 753    Data Row: 816   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4243062]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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2
[SID4243062]
Potency 5.2213Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID4243062]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID4243062]
Potency 10qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID4243062]
Potency 25.929qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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6
[SID4243062]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID4243062]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID4243062]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID4243062]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID4243062]
CC50 34.71A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Sensitize Mycobacterium Tuberculosis to Beta-Lactam Antibiotics [AID434958, Type: confirmatory]
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11
[SID4243062]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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12
[SID4243062]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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13
[SID4243062]
Identification of Molecular Probes that Activate MRP-1 [AID799, Type: screening]multidrug resistance-associated protein 1 [Homo sapiens] [gi:134142337]
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14
[SID92709262]
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA2: Fluorescence-based biochemical gel-based ABPP inhibition [AID652029, Type: other]acyl-protein thioesterase 2 [Homo sapiens] [gi:9966764]
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15
[SID4243062]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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16
[SID4243062]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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17
[SID4243062]
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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18
[SID4243062]
Counterscreen for PME1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2232, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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19
[SID4243062]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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20
[SID4243062]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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21
[SID4243062]
Potency 6.3096qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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22
[SID4243062]
Potency 6.3096qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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23
[SID4243062]
Potency 10qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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24
[SID4243062]
Potency 10qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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25
[SID4243062]
Potency 28.1838qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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26
[SID4243062]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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27
[SID4243062]
Potency 89.1251qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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28
[SID4243062]
IC50 (with Meropenem) 100Screen and Counter Screen to Identify Novel Compounds that Selectively Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434987, Type: confirmatory]
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29
[SID4243062]
Potency 112.202qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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30
[SID4243062]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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31
[SID4243062]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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32
[SID4243062]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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33
[SID4243062]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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34
[SID4243062]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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35
[SID4243062]
uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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36
[SID4243062]
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]regulator of G-protein signaling 16 [Homo sapiens] [gi:156416009]
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37
[SID4243062]
IC50 Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase [AID690, Type: confirmatory]alkaline phosphatase, placental-like preproprotein [Homo sapiens] [gi:157266296]
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38
[SID4243062]
IC50 Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase [AID696, Type: confirmatory]alkaline phosphatase, placental-like preproprotein [Homo sapiens] [gi:157266296]
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39
[SID4243062]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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40
[SID4243062]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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41
[SID4243062]
High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) [AID2550, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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42
[SID4243062]
High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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43
[SID4243062]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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44
[SID4243062]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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45
[SID4243062]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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46
[SID4243062]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
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47
[SID4243062]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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48
[SID4243062]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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49
[SID4243062]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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50
[SID92709262]
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA2: Fluorescence-based biochemical gel-based ABPP inhibition and selectivity [AID652030_2, Type: other]lysophospholipase 2 [Mus musculus] [gi:123122209]
View