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AC1ML9ZP (CID 3216691) - Compound BioActivity Data
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BioActivity Outcomes:
Active(102)
 
 
Inactive(618)
 
 
Inconclusive(35)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(21)
 
 
 
Death TRAILR..(12)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(503)
 
 
 
 
 
Confirmatory(230)
 
 
 
 
 
Literature(21)
 
 
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(54)
 
 
 
 
 
AC50(26)
 
 
 
 
EC50(7)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 686    Data Row: 766   Total Pages: 39   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24802680]
IC50_Mean 0.252Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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2
[SID24802680]
AC50_uM 0.26HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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3
[SID24802680]
IC50_Mean 0.32Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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4
[SID131285800]
IC50 0.4Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by MTT assay [AID593287, Type: Literature]
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5
[SID24802680]
AC50_uM 0.631CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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6
[SID24802680]
AC50_uM 0.678PAX8: non-specific cytotoxicity Measured in Cell-Based System Using Plate Reader - 7054-05_Inhibitor_Dose_DryPowder_Activity [AID743021, Type: confirmatory]
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7
[SID24802680]
AC50_uM 0.839HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Antagonist_Dose_CherryPick_Activity [AID743416, Type: confirmatory]
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8
[SID24802680]
Potency 0.92qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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9
[SID24802680]
AC50_uM 1.11Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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10
[SID24802680]
Potency 1.2589qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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11
[SID24802680]
Potency 1.5849qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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12
[SID131285800]
IC50 1.7Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay [AID593284, Type: Literature]
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13
[SID131285800]
IC50 1.7Cytotoxicity against human 5637 cells after 72 hrs by MTT assay [AID593286, Type: Literature]
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14
[SID24802680]
AC50_uM 1.87HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Antagonist_Dose_CherryPick_Activity [AID743446, Type: confirmatory]
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15
[SID24802680]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID24802680]
Potency 2.1192qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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17
[SID131285800]
IC50 2.3Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay [AID593281, Type: Literature]
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18
[SID24802680]
AC50_uM 3.91MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_Dose_CherryPick_Activity [AID720514, Type: confirmatory]
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19
[SID131285800]
IC50 4.1Cytotoxicity against human HEY cells after 72 hrs by MTT assay [AID593279, Type: Literature]
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20
[SID24802680]
AC50_uM 4.23Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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