Bookmark and Share
AC1ML9ZP (CID 3216691) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(102)
 
 
Inactive(612)
 
 
Inconclusive(35)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(21)
 
 
 
Death TRAILR..(12)
 
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(503)
 
 
 
 
 
Confirmatory(230)
 
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(54)
 
 
 
 
 
AC50(26)
 
 
 
 
EC50(7)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 686    Data Row: 760   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24802680]
IC50_Mean 0.252Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
View
2
[SID24802680]
AC50_uM 0.26HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
3
[SID24802680]
IC50_Mean 0.32Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
View
4
[SID131285800]
IC50 0.4Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by MTT assay [AID593287, Type: Literature]
View
5
[SID24802680]
AC50_uM 0.631CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
View
6
[SID24802680]
AC50_uM 0.678PAX8: non-specific cytotoxicity Measured in Cell-Based System Using Plate Reader - 7054-05_Inhibitor_Dose_DryPowder_Activity [AID743021, Type: confirmatory]
View
7
[SID24802680]
AC50_uM 0.839HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Antagonist_Dose_CherryPick_Activity [AID743416, Type: confirmatory]
View
8
[SID24802680]
Potency 0.92qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
9
[SID24802680]
AC50_uM 1.11Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
View
10
[SID24802680]
Potency 1.2589qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
11
[SID24802680]
Potency 1.5849qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
View
12
[SID131285800]
IC50 1.7Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay [AID593284, Type: Literature]
View
13
[SID131285800]
IC50 1.7Cytotoxicity against human 5637 cells after 72 hrs by MTT assay [AID593286, Type: Literature]
View
14
[SID24802680]
AC50_uM 1.87HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Antagonist_Dose_CherryPick_Activity [AID743446, Type: confirmatory]
View
15
[SID24802680]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
16
[SID24802680]
Potency 2.1192qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
17
[SID131285800]
IC50 2.3Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay [AID593281, Type: Literature]
View
18
[SID24802680]
AC50_uM 3.91MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_Dose_CherryPick_Activity [AID720514, Type: confirmatory]
View
19
[SID131285800]
IC50 4.1Cytotoxicity against human HEY cells after 72 hrs by MTT assay [AID593279, Type: Literature]
View
20
[SID24802680]
AC50_uM 4.23Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
View
21
[SID24802680]
AC50_uM 4.53Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
View
22
[SID24802680]
AC50_uM 4.734MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
23
[SID24802680]
AC50_uM 4.734MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
24
[SID24802680]
AC50_uM 4.734MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
25
[SID24802680]
IC50_Mean 4.97Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
View
26
[SID24802680]
Potency 6.3096qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
27
[SID24802680]
AC50_uM 6.64LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
View
28
[SID131285800]
IC50 6.9Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay [AID593282, Type: Literature]
View
29
[SID131285800]
IC50 7Cytotoxicity against p53 deficient human HCT116 cells expressing p53 after 72 hrs by MTT assay [AID593283, Type: Literature]
View
30
[SID24802680]
AC50_uM 7.12Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
View
31
[SID24802680]
Potency 7.9433VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
32
[SID24802680]
AC50_uM 8.43Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
View
33
[SID24802680]
AC50_uM 9.92HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
View
34
[SID24802680]
Potency 10qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
View
35
[SID24802680]
Potency 10qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
View
36
[SID24802680]
AC50_uM 13.36A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Antagonist_Dose_CherryPick_Activity [AID743412, Type: confirmatory]
View
37
[SID24802680]
AC50_uM 14.37Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
View
38
[SID24802680]
AC50_uM 14.8HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
View
39
[SID24802680]
AC50_uM 19.912MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID493240, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
40
[SID24802680]
Potency 23.7781qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
View
41
[SID24802680]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
42
[SID24802680]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
View
43
[SID24802680]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
44
[SID24802680]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
45
[SID24802680]
Single concentration confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID651580, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
46
[SID24802680]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
47
[SID24802680]
Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
View
48
[SID24802680]
Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
49
[SID24802680]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
View
50
[SID24802680]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
View