Echinomycin (CID 3197) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(138)
 
 
Inactive(200)
 
 
Inconclusive(21)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
BRLZ(5)
 
 
 
7TM GPCR Srsx(5)
 
 
Nuc rec co-ac..(4)
 
 
Alpha TIF(4)
 
 
BioAssay Types:
Screening(179)
 
 
 
 
Confirmatory(145)
 
 
 
 
 
Literature(4)
 
 
BioActivity Types:
Potency(57)
 
 
 
 
 
IC50(8)
 
 
AC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 354    Data Row: 360   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92763358]
Potency 0.0012qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID92763358]
Potency 0.0065Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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3
[SID92763358]
Potency 0.0065Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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4
[SID92763358]
Potency 0.0065Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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5
[SID92763358]
Potency 0.0065Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID92763358]
Potency 0.0117qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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7
[SID92763358]
Potency 0.2055qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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8
[SID92763358]
AC50 0.26Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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9
[SID92763358]
AC50 0.26Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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10
[SID92763358]
Potency 0.3162qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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11
[SID92763358]
Potency 0.3162qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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12
[SID92763358]
Potency 0.5323qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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13
[SID92763358]
Potency 0.5623qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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14
[SID92763358]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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15
[SID92763358]
 Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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16
[SID92763358]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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17
[SID92763358]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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18
[SID92763358]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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19
[SID92763358]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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20
[SID92763358]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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21
[SID92763358]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]
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22
[SID92763358]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]
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23
[SID92763358]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]NCOA2 gene product [Homo sapiens] [gi:5729858]
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24
[SID92763358]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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25
[SID92763358]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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26
[SID92763358]
 uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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27
[SID92763358]
 uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]EPAS1 gene product [Homo sapiens] [gi:40254439]
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28
[SID92763358]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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29
[SID92763358]
 Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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30
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6D2F1 (BDF1) mice [AID192, Type: other]
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31
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice [AID200, Type: other]
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32
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Sarcoma M5076 (intraperitoneal) in B6D2F1 (BDF1) mice [AID286, Type: other]
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33
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia resistant to Adriamycin; NSC 123127, Developed at Scr 08 (intraperitoneal) in CD2F1 (CDF1) mice [AID322, Type: other]
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34
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID328, Type: other]
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35
[SID580231]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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36
[SID92763358]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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37
[SID92763358]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504539, Type: confirmatory]
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38
[SID92763358]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_CherryPick_Activity [AID504592, Type: confirmatory]
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39
[SID92763358]
 Counterscreen for inhibitors of RecBCD: Absorbance-based cell-based high throughput assay to identify inhibitors of bacterial viability [AID651983, Type: screening]
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40
[SID92763358]
 Single concentration confirmation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651995, Type: screening]
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41
[SID92763358]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]
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42
[SID92763358]
 HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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43
[SID92763358]
 Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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44
[SID92763358]
 Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID652007, Type: screening]
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45
[SID92763358]
 Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID652008, Type: screening]
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46
[SID540556]
 NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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47
[SID540556]
 NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain [AID157, Type: other]
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48
[SID540556]
 NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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49
[SID540556]
 NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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50
[SID540556]
 NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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