dipropizine (CID 3169) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(914)
 
 
Inconclusive(28)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
7TM GPCR Srsx(11)
 
 
Tryp SPc(10)
 
 
BioAssay Types:
Screening(545)
 
 
 
 
Confirmatory(274)
 
 
 
 
Literature(77)
 
 
 
BioActivity Types:
Potency(204)
 
 
 
 
IC50(42)
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 834    Data Row: 963   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID855842]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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2
[SID855842]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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3
[SID855842]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
4
[SID855842]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
5
[SID855842]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
6
[SID855842]
 HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
7
[SID855842]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
8
[SID855842]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
9
[SID855842]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
10
[SID855842]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
View
11
[SID855842]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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12
[SID10321630]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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13
[SID10321630]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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14
[SID10321630]
 MDR-1 [AID377, Type: other]ABCB1 gene product [Homo sapiens] [gi:42741659]
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15
[SID56422462]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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16
[SID104171374]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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17
[SID103395114]
 Antitussive activity by inhibition of irritant citric acid aerosol-induced coughing in guinea pig upon oral administration. [AID74202, Type: Literature]
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18
[SID103395114]
 Inhibition of irritant electrically-induced coughing in guinea pig trachea following p.o. administration. [AID74204, Type: Literature]
View
19
[SID56422462]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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20
[SID56422462]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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21
[SID26747219]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
22
[SID8149692]
 Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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23
[SID8149692]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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24
[SID8149692]
 Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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25
[SID8149692]
 Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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26
[SID8149692]
 Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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27
[SID8149692]
 Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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28
[SID8149692]
 Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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29
[SID8149692]
 Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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30
[SID8149692]
 Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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31
[SID8149692]
 Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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32
[SID8149692]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
View
33
[SID104171374]
Potency 15.8489qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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34
[SID56422462]
Potency 35.4813qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
View
35
[SID855842]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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36
[SID855842]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
View
37
[SID855842]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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38
[SID56422462]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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39
[SID56422462]
 Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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40
[SID85788460]
 Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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41
[SID92124271]
 A screen for compounds that inhibit liver stage malaria [AID624349, Type: other]
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42
[SID103914118]
 Screening small molecules to find regulators of human embryonic stem cell survival. [AID493140, Type: screening]
View
43
[SID855842]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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44
[SID855842]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide for Validation Compound Set [AID2706, Type: screening]
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45
[SID855842]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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46
[SID855842]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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47
[SID855842]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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48
[SID26747219]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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49
[SID26747219]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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50
[SID26747219]
Potency qHTS Assay for Lipid Storage Modulators [AID1519, Type: confirmatory]
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