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AP-970/43375858 (CID 3161521) - Compound BioActivity Data
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BioActivity Outcomes:
Active(73)
 
 
Inactive(527)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
 
Bcl-2 like(8)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(390)
 
 
 
 
Confirmatory(220)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(155)
 
 
 
 
 
IC50(35)
 
 
 
AC50(15)
 
 
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 572    Data Row: 628   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24808858]
CC50 4.57e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID24808858]
Potency 0.6497qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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3
[SID24808858]
Potency 0.7051HBEC Cell Viability Secondary Assay for qHTS Assay for Epigenetic Modulators [AID493066, Type: confirmatory]
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4
[SID24808858]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24808858]
AC50_uM 0.85Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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6
[SID24808858]
Potency 1.4068H358 Cell Viability Secondary Assay for qHTS Assay for Epigenetic Modulators: Round 2 [AID493074, Type: confirmatory]
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7
[SID24808858]
AC50_uM 2.21Counterscreen:CMV reporter Measured in Cell-Based System Using Plate Reader - 7054-04_Inhibitor_Dose_DryPowder_Activity [AID743020, Type: confirmatory]
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8
[SID24808858]
Potency 2.807HCC4017 Cell Viability Secondary Assay for qHTS Assay for Epigenetic Modulators [AID493071, Type: confirmatory]
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9
[SID24808858]
Potency 3.6626qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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10
[SID24808858]
Potency 3.6898qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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11
[SID24808858]
AC50_uM 4.12HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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12
[SID24808858]
Potency 5.0119qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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13
[SID24808858]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID24808858]
AC50_uM 5.2Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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15
[SID24808858]
AC50_uM 6.085MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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16
[SID24808858]
AC50_uM 6.085MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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17
[SID24808858]
AC50_uM 6.085MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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18
[SID24808858]
Potency 7.3078qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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19
[SID24808858]
Potency 7.9433Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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20
[SID24808858]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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21
[SID24808858]
Potency 9.2qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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22
[SID24808858]
AC50_uM 9.974MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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23
[SID24808858]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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24
[SID24808858]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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25
[SID24808858]
Potency 11.2202qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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26
[SID24808858]
Potency 11.5821qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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27
[SID24808858]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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28
[SID24808858]
Potency 12.5893Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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29
[SID24808858]
Potency 14.1254qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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30
[SID24808858]
Potency 19.9526qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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31
[SID24808858]
AC50_uM 20.48Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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32
[SID24808858]
Potency 20.5962qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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33
[SID24808858]
AC50_uM 24.764MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID493240, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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34
[SID24808858]
AC50_uM 35MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity [AID540346, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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35
[SID24808858]
AC50_uM 35MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID540335, Type: confirmatory]
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36
[SID24808858]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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37
[SID24808858]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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38
[SID24808858]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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39
[SID24808858]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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40
[SID24808858]
Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput screening assay to identify activators of the GAA30 frataxin promoter [AID588350, Type: screening] [geneid:2395]
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41
[SID24808858]
Luminescence-based cell-based high throughput confirmation assay for activators of the GAA850 frataxin (FXN) promoter [AID588351, Type: screening] [geneid:2395]
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42
[SID24808858]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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43
[SID24808858]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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44
[SID24808858]
HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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45
[SID24808858]
Leishmania major promastigote HTS [AID1063, Type: screening]
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46
[SID24808858]
Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity [AID743247, Type: screening]
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47
[SID24808858]
HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules: Confirmation Assay [AID463116, Type: screening]
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48
[SID24808858]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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49
[SID24808858]
Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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50
[SID24808858]
Counterscreen for inhibitors of Janus kinase 2 mutant JAK2V617F: Cell-based high throughput assay to identify inhibitors of parental Ba/F3 cell viability. [AID1486, Type: screening]
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