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AP-970/43375806 (CID 3161426) - Compound BioActivity Data
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BioActivity Outcomes:
Active(49)
 
 
Inactive(545)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
 
G-alpha(8)
 
 
 
Bcl-2 like(8)
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(388)
 
 
 
 
Confirmatory(204)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(145)
 
 
 
 
 
IC50(35)
 
 
 
AC50(9)
 
 
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 554    Data Row: 615   Total Pages: 31   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24809040]
CC50 6.29e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID24809040]
Potency 0.729qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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3
[SID24809040]
IC50 1.004High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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4
[SID24809040]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24809040]
Potency 3.2885qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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6
[SID24809040]
Potency 3.9811qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID24809040]
AC50_uM 5.17HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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8
[SID24809040]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24809040]
Potency 6.3096Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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10
[SID24809040]
Potency 6.5131qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID24809040]
Potency 7.0795Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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12
[SID24809040]
Potency 7.9433qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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13
[SID24809040]
AC50_uM 8.625MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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14
[SID24809040]
Potency 10qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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15
[SID24809040]
Potency 10qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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16
[SID24809040]
Potency 12.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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17
[SID24809040]
Potency 16.5113Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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18
[SID24809040]
AC50_uM 19.86Counterscreen:CMV reporter Measured in Cell-Based System Using Plate Reader - 7054-04_Inhibitor_Dose_DryPowder_Activity [AID743020, Type: confirmatory]
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19
[SID24809040]
Potency 22.3872qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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20
[SID24809040]
AC50_uM 24.155MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID493240, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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