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Domperidone (CID 3151) - Compound BioActivity Data
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BioActivity Outcomes:
Active(120)
 
 
Inactive(1389)
 
 
Inconclusive(157)
 
 
Unspecified(217)
 
 
Top Targets:
7tm 4(102)
 
 
 
 
 
p450(32)
 
 
 
 
Tryp SPc(17)
 
 
 
ANK(16)
 
 
 
PLDc mTdp1 2(16)
 
 
 
 
BioAssay Types:
Confirmatory(903)
 
 
 
 
 
Screening(633)
 
 
 
 
Literature(237)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(612)
 
 
 
 
 
IC50(211)
 
 
 
 
 
EC50(10)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1396    Data Row: 1883   Total Pages: 95   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503975]
IC50 0.0025Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand [AID61325, Type: Literature]
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2
[SID103503975]
IC50 0.00265DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: confirmatory]D(2) dopamine receptor [gi:118206]
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3
[SID103503975]
IC50 0.00268Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum [AID65470, Type: Literature]
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4
[SID103503975]
IC50 0.0028Tested for its affinity towards D2 receptor in rat striatal membrane [AID64607, Type: Literature]
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5
[SID103503975]
Ki 0.0035Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
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6
[SID103503975]
IC50 0.0052In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding [AID64290, Type: Literature]
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7
[SID103503975]
IC50 0.0136Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 in rat brain synaptic membrane [AID64277, Type: Literature]
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8
[SID103503975]
IC50 0.018DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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9
[SID103503975]
IC50 0.037DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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10
[SID103503975]
IC50 0.05754Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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11
[SID103503975]
Ki 0.152Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196754, Type: Literature]
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12
[SID103503975]
IC50 0.158DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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13
[SID103503975]
IC50 0.162K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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14
[SID103503975]
IC50 0.16218Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state [AID243188, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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15
[SID103503975]
IC50 0.16218Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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16
[SID103503975]
IC50 0.16218Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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17
[SID103503975]
IC50 0.16218Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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18
[SID50103922]
Potency 0.2239qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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19
[SID50103922]
Potency 0.2239qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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20
[SID103503975]
IC50 0.285DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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