Bookmark and Share
Domperidone (CID 3151) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(112)
 
 
Inactive(1372)
 
 
Inconclusive(157)
 
 
Unspecified(196)
 
 
Top Targets:
7TM GPCR Srx(51)
 
 
 
 
 
7TM GPCR Srsx(43)
 
 
 
 
p450(32)
 
 
 
 
Tryp SPc(17)
 
 
 
ANK(16)
 
 
 
BioAssay Types:
Confirmatory(777)
 
 
 
 
 
Screening(630)
 
 
 
 
Literature(200)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(609)
 
 
 
 
 
IC50(203)
 
 
 
 
 
EC50(10)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1366    Data Row: 1837   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503975]
IC50 0.0025Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand [AID61325, Type: Literature]
View
2
[SID103503975]
IC50 0.00265DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
3
[SID103503975]
IC50 0.00268Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum [AID65470, Type: Literature]
View
4
[SID103503975]
IC50 0.0028Tested for its affinity towards D2 receptor in rat striatal membrane [AID64607, Type: Literature]
View
5
[SID103503975]
Ki 0.0035Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells [AID65133, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
6
[SID103503975]
IC50 0.0052In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding [AID64290, Type: Literature]
View
7
[SID103503975]
IC50 0.0136Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 in rat brain synaptic membrane [AID64277, Type: Literature]
View
8
[SID103503975]
IC50 0.018DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
View
9
[SID103503975]
IC50 0.037DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
View
10
[SID103503975]
IC50 0.05754Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
11
[SID103503975]
Ki 0.152Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196754, Type: Literature]
View
12
[SID103503975]
IC50 0.158DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
View
13
[SID103503975]
IC50 0.162K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
14
[SID103503975]
IC50 0.16218Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
15
[SID103503975]
IC50 0.16218Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
View
16
[SID103503975]
IC50 0.16218Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
View
17
[SID50103922]
Potency 0.2239qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
View
18
[SID103503975]
IC50 0.285DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
View
19
[SID103503975]
IC50 0.58884Compound was evaluated for its activity at membrane-bound receptor (M+L+P fraction) from rat frontal cortex [AID196752, Type: Literature]
View
20
[SID103503975]
Ki 0.998Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196755, Type: Literature]
View
21
[SID103503975]
IC50 1.011DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
View
22
[SID103503975]
IC50 1.035DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
View
23
[SID103503975]
IC50 1.065DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
View
24
[SID85230869]
Potency 1.1689Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
View
25
[SID103503975]
IC50 1.332DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
View
26
[SID103503975]
IC50 1.344DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
View
27
[SID103503975]
IC50 1.58489Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View
28
[SID103503975]
IC50 1.99526Compound was evaluated for its activity at solubilized receptor (CHAPS/salt-solubilized preparation) from rat frontal cortex [AID196753, Type: Literature]
View
29
[SID103503975]
IC50 2.125DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
View
30
[SID50103922]
Potency 2.2387qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
View
31
[SID103503975]
IC50 2.3Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay [AID721754, Type: Literature]Multidrug and toxin extrusion protein 1 [gi:74731723]
View
32
[SID103503975]
IC50 2.6DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
View
33
[SID103503975]
IC50 2.614DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
34
[SID103503975]
IC50 2.74DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
View
35
[SID103503975]
IC50 3.055DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
View
36
[SID50103922]
Potency 3.1623qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
View
37
[SID4254117]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
View
38
[SID103503975]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
View
39
[SID103503975]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
View
40
[SID103503975]
IC50 4.218DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
41
[SID50103922]
Potency 4.4668qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
View
42
[SID4254117]
Potency 4.7755Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
43
[SID103503975]
IC50 6.994DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
View
44
[SID103503975]
IC50 7.9Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay [AID721751, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
View
45
[SID103503975]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
View
46
[SID11111029]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
View
47
[SID50103922]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
View
48
[SID103503975]
IC50 10Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
View
49
[SID103503975]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
View
50
[SID103503975]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
View