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SMR000124622 (CID 3143083) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(731)
 
 
Inconclusive(18)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(9)
 
 
 
BioAssay Types:
Screening(530)
 
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(148)
 
 
 
 
 
IC50(48)
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 692    Data Row: 757   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14723283]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID14723283]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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3
[SID14723283]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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4
[SID14723283]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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5
[SID14723283]
Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) [AID651718, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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6
[SID14723283]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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7
[SID14723283]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID14723283]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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9
[SID14723283]
Potency 0.2818qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID14723283]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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11
[SID87225453]
IC50_Mean 20SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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12
[SID87225453]
IC50_Mean 20SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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13
[SID87225453]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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14
[SID87225453]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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15
[SID14723283]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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16
[SID14723283]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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17
[SID14723283]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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18
[SID14723283]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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19
[SID14723283]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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20
[SID14723283]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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21
[SID14723283]
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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22
[SID14723283]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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23
[SID14723283]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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24
[SID14723283]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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25
[SID14723283]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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26
[SID14723283]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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27
[SID14723283]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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28
[SID14723283]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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29
[SID14723283]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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30
[SID14723283]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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31
[SID14723283]
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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32
[SID14723283]
Factor XIa 1536 HTS [AID798, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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33
[SID14723283]
Factor XIa Single Well HTS [AID687, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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34
[SID14723283]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein, partial [Homo sapiens] [gi:190938]
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35
[SID14723283]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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36
[SID14723283]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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37
[SID14723283]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2. [AID950, Type: screening]Apoptosis regulator Bcl-2 [gi:231632]
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38
[SID14723283]
Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein [Homo sapiens] [gi:257380]
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39
[SID14723283]
Primary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translation [AID1285, Type: screening]amyloid precursor protein [Homo sapiens] [gi:257380]
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40
[SID14723283]
Thrombin 1536 HTS [AID1046, Type: screening]prothrombin [Homo sapiens] [gi:339641]
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41
[SID14723283]
Potency qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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42
[SID14723283]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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43
[SID14723283]
Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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44
[SID14723283]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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45
[SID14723283]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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46
[SID14723283]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1007, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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47
[SID14723283]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN. [AID2025, Type: screening]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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48
[SID14723283]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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49
[SID14723283]
Potency qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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50
[SID14723283]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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