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2,6-di-tert-butyl-4-methylphenol (CID 31404) - Compound BioActivity Data
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BioActivity Outcomes:
Active(74)
 
 
Inactive(1177)
 
 
Inconclusive(69)
 
 
Unspecified(227)
 
 
Top Targets:
7tm 4(43)
 
 
NR LBD PPAR(40)
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(25)
 
 
 
NR LBD TR(21)
 
 
 
BioAssay Types:
Confirmatory(627)
 
 
 
 
 
Screening(497)
 
 
 
Literature(259)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(587)
 
 
 
 
 
IC50(107)
 
 
 
 
 
EC50(12)
 
 
 
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1183    Data Row: 1547   Total Pages: 78   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103199241]
IC50 0.04Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by TLC autographic assay [AID403737, Type: Literature]
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2
[SID103199241]
Ki 0.63Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate [AID416126, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103199241]
IC50 0.9Compound was tested for [Ca2+] overload inhibitory activity in the veratridine-induced [Ca2+] overload model of rat cardiac myocytes. [AID196205, Type: Literature]
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4
[SID103199241]
IC50 1.7Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes [AID248526, Type: Literature]
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5
[SID103199241]
IC50 1.7Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane [AID264513, Type: Literature]
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6
[SID103199241]
IC50 3Antioxidant activity assessed as inhibition of copper-induced human LDL oxidation [AID360576, Type: Literature]
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7
[SID103199241]
IC50 3.18Induction of DNA fragmentation in human HL60 cells after 16 hrs [AID282840, Type: Literature]
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8
[SID103199241]
IC50 3.2Inhibition of NADH-induced lipid peroxidation in rat brain microsome [AID312786, Type: Literature]
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9
[SID103199241]
IC50 3.25Inhibition of ferrous induced lipid peroxidation in rat brain microsomes [AID262310, Type: Literature]
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10
[SID103199241]
IC50 3.25Ability to inhibit [Fe2+] induced lipid peroxidation (LPO) in rat brain microsomes [AID195850, Type: Literature]
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11
[SID103199241]
IC50 4.03Compound was tested for its inhibitory concentration against formation of lipid peroxides in rat brain homogenates by thiobarbituric acid reactive substances (TBARS) assay according to the method of Stocks. [AID195714, Type: Literature]
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12
[SID103199241]
IC50 4.03Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay [AID314540, Type: Literature]
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13
[SID103199241]
IC50 4.5Antioxidant activity assessed as DPPH free radical scavenging activity by spectrophotometric analysis [AID750848, Type: Literature]
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14
[SID103199241]
IC50 4.5Antioxidant activity assessed as DPPH radical scavenging activity [AID1064280, Type: Literature]
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15
[SID103199241]
IC50 5.9Compound was tested for 50% Inhibition of lipid peroxidation in rat brain homogenate [AID195548, Type: Literature]
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16
[SID103199241]
IC50 5.9Compound was tested for its inhibitory activity against lipid peroxidation in rat brain homogenates. [AID179221, Type: Literature]
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17
[SID103199241]
EC50 6Ability to protect cerebellar granule cells (CGC) from iodoacetate (IAA)-induced toxicity [AID196215, Type: Literature]
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18
[SID103199241]
IC50 6.2Inhibition of Fe2+-induced lipid peroxidation in rat brain homogenate [AID312787, Type: Literature]
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19
[SID103199241]
IC50 6.38Antioxidant activity assessed as H2O2 scavenging activity by NBT reduction assay [AID758227, Type: Literature]
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20
[SID103199241]
IC50 6.85Antioxidant activity assessed as ABTS radical scavenging activity after 10 mins by spectrophotometric analysis [AID758228, Type: Literature]
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