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312714-12-8 (CID 3136298) - Compound BioActivity Data
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BioActivity Outcomes:
Active(109)
 
 
Inactive(500)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srsx(17)
 
 
7TM GPCR Srx(16)
 
 
alkPPc(16)
 
 
 
Bcl-2 like(9)
 
 
 
Tryp SPc(8)
 
 
 
BioAssay Types:
Screening(375)
 
 
 
 
Confirmatory(228)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(54)
 
 
 
 
AC50(9)
 
 
 
EC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 566    Data Row: 629   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24801477]
IC50 0.57543TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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2
[SID24801477]
IC50 0.57543TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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3
[SID125317283]
IC50_Mean 0.989SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 [AID624087, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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4
[SID24801477]
Potency 1qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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5
[SID24801477]
Potency 1.2589qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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6
[SID24801477]
AC50_uM 1.45Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity [AID1053173, Type: confirmatory]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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7
[SID24801477]
IC50_Mean 1.45Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence resonance energy transfer selectivity assay [AID624384, Type: confirmatory]small ubiquitin-related modifier 2 isoform b precursor [Homo sapiens] [gi:54792071]
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8
[SID24801477]
Potency 1.5849qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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9
[SID125317283]
IC50_Mean 2.32SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 [AID624089, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3A isoform a [Homo sapiens] [gi:21955158]
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10
[SID24801477]
Potency 2.5119qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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11
[SID24801477]
IC50 3.015Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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12
[SID24801477]
IC50 3.015Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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13
[SID24801477]
Potency 3.5481qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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14
[SID24801477]
Potency 3.9811qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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15
[SID124360094]
AC50_uM 4.46C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_DryPowder_Activity [AID588363, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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16
[SID24801477]
IC50_Mean 4.87Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence polarization selectivity assay [AID624385, Type: confirmatory]small ubiquitin-related modifier 2 isoform b precursor [Homo sapiens] [gi:54792071]
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17
[SID24801477]
IC50_Mean 4.9Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay [AID624383, Type: confirmatory]SUMO-1 [Homo sapiens] [gi:1762973]
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18
[SID125317283]
IC50_Mean 5.03SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay [AID602136, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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19
[SID24801477]
IC50 5.10603Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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20
[SID125317283]
IC50_Mean 5.37SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay [AID588857, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3A isoform a [Homo sapiens] [gi:21955158]
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