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7-chloro-N-methyl-4-nitro-2,1,3-benzoxadiazol-5-amine (CID 3128197) - Compound BioActivity Data
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BioActivity Outcomes:
Active(122)
 
 
Inactive(504)
 
 
Inconclusive(37)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
G-alpha(8)
 
 
 
Bcl-2 like(8)
 
 
RGS RGS4(7)
 
 
 
BioAssay Types:
Screening(407)
 
 
 
 
Confirmatory(232)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(53)
 
 
 
 
 
EC50(20)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 595    Data Row: 670   Total Pages: 34   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24817041]
CC50 1.22e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID24817041]
Potency 0.3548qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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3
[SID24817041]
Potency 0.4467qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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4
[SID24817041]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24817041]
Potency 0.6513qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID24817041]
EC50 0.752Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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7
[SID24817041]
Potency 1qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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8
[SID24817041]
IC50 1.11343Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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9
[SID24817041]
IC50 1.676Counterscreen for inhibitors of TLR9-MyD88 binding: Luminescence-based cell-based high throughput dose response assay to identify cytotoxic compounds using TLR9-MyD88 CHO cells [AID588339, Type: confirmatory]
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10
[SID24817041]
EC50_uM 1.77Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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11
[SID24817041]
Potency 2.5929qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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12
[SID24817041]
IC50 2.951Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding [AID588340, Type: confirmatory]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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13
[SID24817041]
IC50 2.96uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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14
[SID24817041]
Potency 3.2643qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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15
[SID24817041]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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16
[SID24817041]
Potency 3.5481VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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17
[SID24817041]
EC50 3.65A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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18
[SID24817041]
IC50 4.73Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID588341, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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19
[SID24817041]
Potency 4.7755qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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20
[SID24817041]
AC50_uM 5.306Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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