pyrrolidine (CID 31268) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(6)
 
 
Unspecified(5)
 
 
BioAssay Types:
Literature(8)
 
 
 
 
BioActivity Types:
Kd(1)
 
 
Ki(1)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189394]
Kd 25Ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 2 [AID30389, Type: Literature]
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2
[SID103189394]
Ki 38000Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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3
[SID103189394]
 Maximum percent of enhancement of binding. [AID30377, Type: Literature]
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4
[SID103189394]
 Compounds was evaluate for their ability to enhance (+/-)-[3H]nicotine binding at a dose range 10 E -10 - 10 E -6 M was reported [AID30521, Type: Literature]
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5
[SID103189394]
 Maximum percent of inhibition of binding was determined [AID30378, Type: Literature]
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6
[SID103189394]
 Compound was evaluated for ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 1; 10e-10-10e-6 [AID30382, Type: Literature]
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7
[SID109780]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P1534 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID316, Type: other]
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8
[SID109780]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P1534 Leukemia (intraperitoneal) in DBA/2 mice [AID314, Type: other]
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9
[SID109780]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lewis Lung Carcinoma (subcutaneous) in B6D2F1 (BDF1) mice [AID270, Type: other]
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10
[SID109780]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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11
[SID103189394]
 Superoxide release activity in potassium phosphate buffer at pH 7.4 and 25 uM after 30 mins by luminol-based colorimetric assay [AID661629, Type: Literature]
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12
[SID103189394]
 Hydrogen peroxide release activity in potassium phosphate buffer at pH 7.4 after 60 mins by xylene-orange based colorimetric assay [AID661627, Type: Literature]
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