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zingerone (CID 31211) - Compound BioActivity Data
.
BioActivity Outcomes:
Inactive(81)
 
 
Inconclusive(12)
 
 
Unspecified(23)
 
 
Top Targets:
NR LBD AR(9)
 
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD ER(7)
 
 
 
Tyrosinase(6)
 
 
NR LBD Fxr(4)
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
Literature(24)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(80)
 
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 116    Data Row: 116   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192537]
IC50 100Inhibition of mushroom tyrosinase [AID450483, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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2
[SID103192537]
IC50 100Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay [AID450477, Type: Literature]
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3
[SID103192537]
IC50 100Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells after 72 hrs [AID450471, Type: Literature]
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4
[SID103192537]
ED50 129Effective dose to protect IMR-32 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay [AID91529, Type: Literature]
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5
[SID103192537]
ED50 129Effective dose to protect PC12 cells from beta-Amyloid (BA) insult was determined using MTT reduction assay [AID156507, Type: Literature]
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6
[SID103192537]
IC50 153Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay [AID473864, Type: Literature]Androgen receptor [gi:113830]
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7
[SID103192537]
Inhibition of mushroom tyrosinase at 1 uM [AID450478, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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8
[SID103192537]
Inhibition of mushroom tyrosinase at 3 uM [AID450479, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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9
[SID103192537]
Inhibition of mushroom tyrosinase at 10 uM [AID450480, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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10
[SID103192537]
Inhibition of mushroom tyrosinase at 30 uM [AID450481, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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11
[SID103192537]
Inhibition of mushroom tyrosinase at 100 uM [AID450482, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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12
[SID103192537]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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13
[SID103192537]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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14
[SID103192537]
Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 1 uM after 72 hrs [AID450466, Type: Literature]
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15
[SID103192537]
Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 3 uM after 72 hrs [AID450467, Type: Literature]
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16
[SID103192537]
Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 10 uM after 72 hrs [AID450468, Type: Literature]
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17
[SID103192537]
Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 30 uM after 72 hrs [AID450469, Type: Literature]
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18
[SID103192537]
Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 1 uM after 68 hrs by WST8 assay [AID450472, Type: Literature]
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19
[SID103192537]
Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 3 uM after 68 hrs by WST8 assay [AID450473, Type: Literature]
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20
[SID103192537]
Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 10 uM after 68 hrs by WST8 assay [AID450474, Type: Literature]
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21
[SID103192537]
Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 30 uM after 68 hrs by WST8 assay [AID450475, Type: Literature]
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22
[SID103192537]
Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 100 uM after 68 hrs by WST8 assay [AID450476, Type: Literature]
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23
[SID103192537]
Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 100 uM after 72 hrs [AID450470, Type: Literature]
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24
[SID144212810]
Ratio Potency (uM) qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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25
[SID144212810]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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26
[SID144212810]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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27
[SID144212810]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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28
[SID144212810]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway [AID743223, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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29
[SID144212810]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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30
[SID144212810]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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31
[SID144212810]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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32
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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33
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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34
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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35
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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36
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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37
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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38
[SID144212810]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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39
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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40
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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41
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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42
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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43
[SID144212810]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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44
[SID144212810]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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45
[SID144212810]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743215, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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46
[SID144212810]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743226, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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47
[SID144212810]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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48
[SID144212810]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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49
[SID144212810]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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50
[SID144212810]
qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743242, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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