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BioActivity Data for Compound Valproic Acid (CID 3121)

BioActivity Outcomes:
Active(45)
 
 
Inactive(1116)
 
 
Inconclusive(44)
 
 
Unspecified(2345)
 
 
Top Targets:
7tm 4(59)
 
 
 
NR LBD PPAR(39)
 
 
 
NR LBD ER(29)
 
 
 
 
NR LBD AR(28)
 
 
 
 
p450(23)
 
 
 
 
BioAssay Types:
Confirmatory(705)
 
 
 
 
 
Literature(696)
 
 
 
 
 
Screening(357)
 
 
 
Summary(72)
 
 
BioActivity Types:
Potency(523)
 
 
 
 
 
IC50(163)
 
 
 
 
AC50(6)
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3133    Data Row: 3550   Total Pages: 178   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177883]
IC50 39Inhibition of human recombinant HDAC1 [AID569928, Type: Literature]Histone deacetylase 1 [gi:2498443]
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2
[SID26752921]
Potency 501.187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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3
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 3 [gi:3334210]
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4
[SID103177883]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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5
[SID103177883]
Succinate semialdehyde dehydrogenase inhibitor [AID742836, Type: Literature]Succinate-semialdehyde dehydrogenase, mitochondrial [gi:7531278]
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6
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 1 [gi:2498443]
View
7
[SID103177883]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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8
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 9 [gi:19865267]
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9
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 11 [gi:26394832]
View
10
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 10 [gi:27734403]
View
11
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 8 [gi:29839394]
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12
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 7 [gi:30913097]
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13
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 2 [gi:68068066]
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14
[SID103177883]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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15
[SID103177883]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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16
[SID103177883]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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17
[SID103177883]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
View
18
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 6 [gi:205371758]
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19
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 4 [gi:259016348]
View
20
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 5 [gi:296434519]
View