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Valproic Acid (CID 3121) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(1099)
 
 
Inconclusive(45)
 
 
Unspecified(2313)
 
 
Top Targets:
NR LBD PPAR(39)
 
 
 
7TM GPCR Srx(31)
 
 
 
NR LBD ER(29)
 
 
 
 
7TM GPCR Srsx(28)
 
 
 
NR LBD AR(28)
 
 
 
 
BioAssay Types:
Confirmatory(698)
 
 
 
 
 
Literature(677)
 
 
 
 
 
Screening(348)
 
 
 
Summary(72)
 
 
BioActivity Types:
Potency(523)
 
 
 
 
 
IC50(162)
 
 
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3083    Data Row: 3500   Total Pages: 175   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177883]
IC50 39Inhibition of human recombinant HDAC1 [AID569928, Type: Literature]Histone deacetylase 1 [gi:2498443]
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2
[SID26752921]
Potency 501.187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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3
[SID103177883]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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4
[SID103177883]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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5
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by Western blot [AID317819, Type: Literature]Histone deacetylase 1 [gi:2498443]
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6
[SID103177883]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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7
[SID103177883]
Compound was tested for the inhibition of Gamma-amino-N-butyrate transaminase; Active [AID73513, Type: Literature]
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8
[SID103177883]
Compound was tested for the inhibition of succinic semialdehyde dehydrogenase; Active [AID208983, Type: Literature]
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9
[SID103177883]
Compound was evaluated for the anticonvulsant activity in amygdala kindled rats; Active [AID170147, Type: Literature]
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10
[SID103177883]
Anti-convulsant activity in experimental animal model; ++ = relative to valproate [AID250473, Type: Literature]
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11
[SID103177883]
Increase in GRP78 protein level in HEK293 cells at 1 mM by immunoblot [AID299655, Type: Literature]
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12
[SID103177883]
Increase in protein disulfide isomerase level in HEK293 cells at 1 mM by immunoblot [AID299648, Type: Literature]
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13
[SID103177883]
Anticonvulsant activity against pentylenetetrazole-induced seizures in Albino mouse at 300 mg/kg, ip after 0.5 hrs [AID305065, Type: Literature]
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14
[SID48416692]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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15
[SID103177883]
Antioxidant activity against PTZ-induced lipid peroxidation in Swiss albino mouse brain assessed as malondialdehyde content per mg of protein at 100 mg/kg, ip preincubated for 30 mins before PTZ challenge measured after 4 hrs by TBARS assay [AID394951, Type: Literature]
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16
[SID103177883]
Antioxidant activity against PTZ-induced decrease in GSH-Px activity in Swiss albino mouse brain assessed as oxidized NADPH level per mg of protein at 100 mg/kg, ip administered 30 mins before PTZ challenge measured after 4 hrs by spectrophotometry [AID394952, Type: Literature]
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17
[SID103177883]
Anticonvulsant activity against electric stimulation-induced pharmacoresistant limbic epilepsy in Sprague-Dawley rat kindling model assessed as reduction of seizure severity and excitability at > 300 mg/kg, ip administered 15 mins after last electric stimulation [AID471593, Type: Literature]
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18
[SID103177883]
Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs [AID482726, Type: Literature]
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19
[SID103177883]
Anticonvulsant activity in CF1 albino mouse assessed as inhibition of subcutaneous pentylenetetrazole-induced seizures at 300 mg/kg, ip after 0.5 hrs [AID482732, Type: Literature]
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20
[SID103177883]
Inhibition of HDAC in human GM15850 cells assessed as increase in total acetylated histone level at 400 uM after 12 hrs by Western blot analysis [AID503529, Type: Literature]
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