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Valproic Acid (CID 3121) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(1082)
 
 
Inconclusive(53)
 
 
Unspecified(2069)
 
 
Top Targets:
NR LBD PPAR(39)
 
 
 
7TM GPCR Srx(31)
 
 
 
NR LBD ER(29)
 
 
 
 
NR LBD AR(28)
 
 
 
 
7TM GPCR Srsx(28)
 
 
 
BioAssay Types:
Literature(645)
 
 
 
 
 
Confirmatory(581)
 
 
 
 
 
Screening(347)
 
 
 
Summary(72)
 
 
BioActivity Types:
Potency(521)
 
 
 
 
 
IC50(162)
 
 
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2837    Data Row: 3247   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177883]
IC50 39Inhibition of human recombinant HDAC1 [AID569928, Type: Literature]Histone deacetylase 1 [gi:2498443]
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2
[SID26752921]
Potency 501.187qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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3
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 3 [gi:3334210]
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4
[SID103177883]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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5
[SID103177883]
Succinate semialdehyde dehydrogenase inhibitor [AID742836, Type: other]Succinate-semialdehyde dehydrogenase, mitochondrial [gi:7531278]
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6
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 1 [gi:2498443]
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7
[SID103177883]
Inhibition of HDAC in human GM15850 cells assessed as increase in total acetylated histone level at 400 uM after 12 hrs by western blot analysis [AID503529, Type: Literature]
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8
[SID103177883]
Induction of autophagy in rat stable inducible PC12 cells expressing A53T alpha-synuclein assessed as A53T alpha-synuclein clearance at 1 uM after 24 hrs by densitometric analysis [AID513626, Type: Literature]
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9
[SID103177883]
Induction of autophagy in rat stable inducible PC12 cells expressing EGFP-HDQ74 assessed as soluble EGFP-HDQ74 clearance at 1 uM after 96 hrs by densitometric analysis [AID513627, Type: Literature]
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10
[SID103177883]
Induction of autophagy in human SK-N-MC cells expressing EGFP-HDQ74 assessed as reduction in EGFP-HDQ74 aggregation at 1 uM after 48 hrs by densitometric analysis [AID513628, Type: Literature]
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11
[SID103177883]
Protection of neurodegeneration in zebrafish Huntington's disease model expressing EGFP-tagged huntingtin exon with EGFP-HDQ71 in rod photoreceptor assessed as decrease in EGFP-HDQ74 aggregation at 10 uM [AID514302, Type: Literature]
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12
[SID103177883]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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13
[SID103177883]
Compound was tested for the inhibition of succinic semialdehyde dehydrogenase; Active [AID208983, Type: Literature]
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14
[SID103177883]
Anti-convulsant activity in experimental animal model; ++ = relative to valproate [AID250473, Type: Literature]
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15
[SID103177883]
Increase in GRP78 protein level in HEK293 cells at 1 mM by immunoblot [AID299655, Type: Literature]
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16
[SID103177883]
Antioxidant activity against PTZ-induced lipid peroxidation in Swiss albino mouse brain assessed as malondialdehyde content per mg of protein at 100 mg/kg, ip preincubated for 30 mins before PTZ challenge measured after 4 hrs by TBARS assay [AID394951, Type: Literature]
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17
[SID103177883]
Antioxidant activity against PTZ-induced decrease in GSH-Px activity in Swiss albino mouse brain assessed as oxidized NADPH level per mg of protein at 100 mg/kg, ip administered 30 mins before PTZ challenge measured after 4 hrs by spectrophotometry [AID394952, Type: Literature]
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18
[SID103177883]
Increase in protein disulfide isomerase level in HEK293 cells at 1 mM by immunoblot [AID299648, Type: Literature]
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19
[SID103177883]
Anticonvulsant activity against pentylenetetrazole-induced seizures in Albino mouse at 300 mg/kg, ip after 0.5 hrs [AID305065, Type: Literature]
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20
[SID103177883]
Anticonvulsant activity against electric stimulation-induced pharmacoresistant limbic epilepsy in Sprague-Dawley rat kindling model assessed as reduction of seizure severity and excitability at > 300 mg/kg, ip administered 15 mins after last electric stimulation [AID471593, Type: Literature]
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21
[SID103177883]
Anticonvulsant activity in CF1 albino mouse assessed as inhibition of maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs [AID482726, Type: Literature]
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22
[SID103177883]
Anticonvulsant activity in CF1 albino mouse assessed as inhibition of subcutaneous pentylenetetrazole-induced seizures at 300 mg/kg, ip after 0.5 hrs [AID482732, Type: Literature]
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23
[SID103177883]
FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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24
[SID103177883]
FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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25
[SID103177883]
FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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26
[SID103177883]
FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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27
[SID103177883]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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28
[SID103177883]
Compound was tested for the inhibition of Gamma-amino-N-butyrate transaminase; Active [AID73513, Type: Literature]
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29
[SID48416692]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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30
[SID103177883]
Compound was evaluated for the anticonvulsant activity in amygdala kindled rats; Active [AID170147, Type: Literature]
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31
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 9 [gi:19865267]
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32
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 11 [gi:26394832]
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33
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 10 [gi:27734403]
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34
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 8 [gi:29839394]
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35
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 7 [gi:30913097]
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36
[SID103177883]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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37
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 2 [gi:68068066]
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38
[SID103177883]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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39
[SID103177883]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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40
[SID103177883]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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41
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 6 [gi:205371758]
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42
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 4 [gi:259016348]
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43
[SID103177883]
Inhibition of human HDAC in A549 cells assessed as increase in histone-H4 acetylation at 150 uM after 24 hrs by western blot [AID317819, Type: Literature]Histone deacetylase 5 [gi:296434519]
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44
[SID103177883]
IC50 1Antiproliferative activity against human A549 cells after 3 days [AID317817, Type: Literature]
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45
[SID103177883]
IC50 50In vitro inhibition of [3H]GABA uptake in rat Hippocampal slices. [AID179593, Type: Literature]
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46
[SID103177883]
IC50 50.1Inhibition of AK1A1 [AID537158, Type: Literature]
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47
[SID103177883]
IC50 50.1Inhibition of rat kidney aldehyde reductase at 0.1 mM after 20 mins by spectrometric analysis [AID462443, Type: Literature]Alcohol dehydrogenase [NADP(+)] [gi:1703237]
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48
[SID103177883]
IC50 56.1Inhibition of Fischer-344 rat kidney AK1A1 [AID537154, Type: Literature]Alcohol dehydrogenase [NADP(+)] [gi:1703237]
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49
[SID103177883]
IC50 56.1Inhibition of Fischer-344 rat kidney ALR1 using D,L-glyceraldehyde as substrate by spectrophotometry [AID720963, Type: Literature]Aldose reductase [gi:1168407]
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50
[SID103177883]
IC50 56.1Inhibition of Wistar rat kidney aldose reductase 1 [AID382323, Type: Literature]
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