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N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide (CID 3111211) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(475)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
KCNQ channel(28)
 
 
 
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(13)
 
 
CAP ED(7)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(318)
 
 
 
Confirmatory(174)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(28)
 
 
 
EC50(26)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 453    Data Row: 503   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104223736]
EC50 0.23Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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2
[SID103073346]
EC50 0.35924Mode of action assay-Confirmatory dose response assay for compounds that activate KCNQ2 potassium channels [AID493037, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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3
[SID103073346]
EC50 0.36643Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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4
[SID103073346]
EC50 0.36643Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 3 [Rattus norvegicus] [gi:15826856]
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5
[SID103073346]
EC50 0.36865Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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6
[SID47200766]
EC50 0.41Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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7
[SID103073346]
EC50 0.51251Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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8
[SID103073346]
EC50 0.51251Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
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9
[SID103073346]
EC50 2.4Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
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10
[SID103073346]
EC50 2.4Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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11
[SID47200766]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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13
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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14
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily E member 1 [Homo sapiens] [gi:189095237]
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15
[SID47200766]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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16
[SID47200766]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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17
[SID47200766]
Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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18
[SID47200766]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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19
[SID47200766]
KCNQ2 Counter screen for compounds that protect hERG from block by proarrhythmic agents [AID1942, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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20
[SID47200766]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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21
[SID47200766]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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22
[SID47200766]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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23
[SID47200766]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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24
[SID47200766]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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25
[SID47200766]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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26
[SID47200766]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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27
[SID47200766]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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28
[SID47200766]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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29
[SID47200766]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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30
[SID47200766]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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31
[SID47200766]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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32
[SID47200766]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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33
[SID47200766]
Potency qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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34
[SID47200766]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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35
[SID47200766]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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36
[SID47200766]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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37
[SID47200766]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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38
[SID47200766]
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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39
[SID47200766]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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40
[SID47200766]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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41
[SID47200766]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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42
[SID47200766]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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43
[SID47200766]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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44
[SID47200766]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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45
[SID47200766]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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46
[SID47200766]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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47
[SID47200766]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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48
[SID47200766]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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49
[SID47200766]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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50
[SID47200766]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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