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N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide (CID 3111211) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(481)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
KCNQ channel(28)
 
 
 
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(13)
 
 
CAP ED(7)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(318)
 
 
 
Confirmatory(174)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(28)
 
 
 
EC50(26)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 453    Data Row: 509   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104223736]
EC50 0.23Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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2
[SID103073346]
EC50 0.35924Mode of action assay-Confirmatory dose response assay for compounds that activate KCNQ2 potassium channels [AID493037, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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3
[SID103073346]
EC50 0.36643Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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4
[SID103073346]
EC50 0.36643Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 3 [Rattus norvegicus] [gi:15826856]
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5
[SID103073346]
EC50 0.36865Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
6
[SID47200766]
EC50 0.41Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
7
[SID103073346]
EC50 0.51251Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
8
[SID103073346]
EC50 0.51251Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
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9
[SID103073346]
EC50 2.4Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
View
10
[SID103073346]
EC50 2.4Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
11
[SID47200766]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily E member 1 [Homo sapiens] [gi:189095237]
View
13
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
14
[SID103073346]
EC50 31.9263Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
View
15
[SID47200766]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
View
16
[SID47200766]
KCNQ2 Counter screen for compounds that protect hERG from block by proarrhythmic agents [AID1942, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
17
[SID47200766]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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18
[SID47200766]
Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
19
[SID47200766]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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20
[SID47200766]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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