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Citric Acid (CID 311) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(1001)
 
 
Inconclusive(46)
 
 
Unspecified(153)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(28)
 
 
 
NR LBD PPAR(28)
 
 
 
NR LBD ER(27)
 
 
 
 
NR LBD AR(26)
 
 
 
 
BioAssay Types:
Confirmatory(453)
 
 
 
 
 
Screening(341)
 
 
 
 
Summary(63)
 
 
 
Literature(32)
 
 
 
 
BioActivity Types:
Potency(441)
 
 
 
 
 
IC50(138)
 
 
 
 
Ki(3)
 
 
Kd(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 816    Data Row: 1226   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103387432]
Kd 2.5Binding affinity for Helicobacter pylori DHQase 2 [AID260163, Type: Literature]3-dehydroquinate dehydratase [gi:2492957]
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2
[SID47193731]
IC50 3.545Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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3
[SID47193731]
IC50 3.545Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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4
[SID47193731]
IC50 3.708Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID651672, Type: confirmatory]perilipin-1 [Homo sapiens] [gi:223718203]
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5
[SID47193731]
IC50 5.632Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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6
[SID47193731]
IC50 5.632Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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7
[SID103387432]
Kd 7.3Binding affinity for Streptomyces coelicolor DHQase 2 [AID260164, Type: Literature]3-dehydroquinate dehydratase [gi:8039781]
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8
[SID17389961]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID17389961]
Potency 50.1187Cell Viability - LYMP2-007 [AID979, Type: confirmatory]
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10
[SID26752850]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID47193731]
Potency 79.4328qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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12
[SID47193731]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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13
[SID47193731]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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14
[SID47193731]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
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15
[SID46394149]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain B, Structure Of Pure (N5-Carboxyaminoimidazole Ribonucleotide Mutase) Mutant H59n From The Acidophilic Bacterium Acetobacter Aceti, At Ph 5.4 [gi:110591482]
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16
[SID46394150]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain B, Structure Of Pure (N5-Carboxyaminoimidazole Ribonucleotide Mutase) H59n From The Acidophilic Bacterium Acetobacter Aceti, Bound To Isocair [gi:110591503]
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17
[SID46393959]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, H. Pylori Type Ii Dhqase In Complex With Citrate [gi:90108965]
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18
[SID47193731]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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19
[SID47193731]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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20
[SID46392735]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Sh2 In Complex With Fragment2. [gi:46015001]
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21
[SID46393096]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Mycobacterium Tuberculosis Ftsz In Complex With Citrate [gi:52695397]
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22
[SID46393906]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Dissection Of Mannosylglycerate Synthase: An Archetypal Mannosyltransferase [gi:71042670]
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23
[SID89571]
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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24
[SID17389961]
Cellular Toxicity (caspase-3) Jurkat [AID655, Type: confirmatory]
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25
[SID17389961]
Cell Viability - Jurkat [AID426, Type: confirmatory]
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26
[SID48415787]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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27
[SID103387432]
Km 110Inhibitory activity against rat ATP-Citrate lyase measured in terms of Km. [AID32396, Type: Literature]
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28
[SID103387432]
IC50 300Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis [AID734755, Type: Literature]Alpha-ketoglutarate-dependent dioxygenase FTO [gi:148841515]
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29
[SID103387432]
Ki 490Inhibition of Bacillus licheniformis BS3 beta-lactamase at pH 5 [AID420346, Type: Literature]Beta-lactamase [gi:115032]
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30
[SID103387432]
Ki 490Inhibition of Bacillus licheniformis beta-lactamase BS3 in 25 mM acetate buffer at pH 5 [AID406767, Type: Literature]
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31
[SID103387432]
Ki 730Inhibition of beta-lactamase TEM1 in 25 mM acetate buffer at pH 5 [AID406768, Type: Literature]
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32
[SID103387432]
IC50 40000Inhibitory activity against SH2 domain of human p60 c-Src tyrosine kinase using surface plasmon resonance (SPR) assay. [AID224309, Type: Literature]
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33
[SID103387432]
Binding energy by using the equation deltaG obsd = -RT ln KD [AID227718, Type: Literature]
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34
[SID103387432]
Hypoglycemic activity in Swiss-Webster mouse assessed as change plasma glucose level at 250 mg/kg, ip after 4 hrs [AID398683, Type: Literature]
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35
[SID103387432]
Toxicity in brine shrimp [AID398684, Type: Literature]
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36
[SID47193731]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID103387432]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A1 [gi:231473]
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38
[SID103387432]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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39
[SID103387432]
IC50 DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) [AID625174, Type: other]Caspase-1 [gi:266321]
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40
[SID103387432]
IC50 DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) [AID625159, Type: other]Nitric oxide synthase, brain [gi:266646]
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41
[SID103387432]
DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) [AID625160, Type: other]Nitric oxide synthase, inducible [gi:266649]
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42
[SID103387432]
IC50 DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
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43
[SID103387432]
IC50 DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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44
[SID103387432]
IC50 DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) [AID625242, Type: other]Cholecystokinin receptor type A [gi:416772]
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45
[SID103387432]
DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) [AID625232, Type: other]Vasoactive intestinal polypeptide receptor 1 [gi:418253]
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46
[SID103387432]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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47
[SID103387432]
IC50 DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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48
[SID103387432]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2a [gi:543740]
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49
[SID103387432]
IC50 DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M5 [gi:543761]
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50
[SID103387432]
IC50 DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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