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Diphenhydramine (CID 3100) - Compound BioActivity Data
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BioActivity Outcomes:
Active(101)
 
 
Inactive(766)
 
 
Inconclusive(93)
 
 
Unspecified(585)
 
 
Top Targets:
7tm 4(68)
 
 
 
 
p450(34)
 
 
 
 
 
NR LBD GR(9)
 
 
 
 
CAP ED(9)
 
 
 
NR LBD ER(9)
 
 
 
 
BioAssay Types:
Confirmatory(625)
 
 
 
 
 
Screening(285)
 
 
 
Literature(226)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(420)
 
 
 
 
 
IC50(139)
 
 
 
 
Ki(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1281    Data Row: 1545   Total Pages: 78   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189265]
IC50 0.001Antihistaminic activity against Histamine H1 receptor was measured on isolated terminal part of guinea pig ileum [AID86581, Type: Literature]Histamine H1 receptor [gi:399889]
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2
[SID103189265]
Kd 0.01175Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins [AID626461, Type: Literature]Histamine H1 receptor [gi:399889]
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3
[SID103189265]
Ki 0.01479Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting [AID626411, Type: Literature]Histamine H1 receptor [gi:547645]
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4
[SID103189265]
IC50 0.162DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: confirmatory]Muscarinic acetylcholine receptor M5 [gi:543761]
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5
[SID103189265]
IC50 0.171DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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6
[SID11111059]
Potency 0.1995qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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7
[SID103189265]
IC50 0.346DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: confirmatory]Muscarinic acetylcholine receptor M1 [gi:113118]
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8
[SID103189265]
IC50 0.372DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: confirmatory]Muscarinic acetylcholine receptor M4 [gi:23503039]
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9
[SID103189265]
IC50 0.647DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: confirmatory]Muscarinic acetylcholine receptor M3 [gi:113125]
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10
[SID103189265]
IC50 0.98DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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11
[SID103189265]
IC50 1.05DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: confirmatory]Muscarinic acetylcholine receptor M2 [gi:113122]
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12
[SID103189265]
IC50 1.118DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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13
[SID103189265]
IC50 1.295DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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14
[SID124879863]
Potency 1.495qHTS profiling of Chloroquine Analogs as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743326, Type: confirmatory]
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15
[SID11111059]
Potency 2.5119qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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16
[SID103189265]
IC50 2.5704Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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17
[SID103189265]
IC50 3.542DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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18
[SID11111060]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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19
[SID103189265]
IC50 6Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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20
[SID103189265]
IC50 7.28DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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