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N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine (CID 3081361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(511)
 
 
Inactive(309)
 
 
Inconclusive(51)
 
 
Unspecified(547)
 
 
Top Targets:
PKc(99)
 
 
 
 
PKc like(80)
 
 
 
 
STKc AGC(46)
 
 
 
 
PTKc Abl(44)
 
 
 
 
 
PTKc EGFR(40)
 
 
 
 
BioAssay Types:
Literature(1137)
 
 
 
 
 
Confirmatory(222)
 
 
 
 
Summary(24)
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(882)
 
 
 
 
Potency(131)
 
 
 
 
IC50(77)
 
 
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1151    Data Row: 1418   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID435935, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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2
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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3
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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6
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103194628]
IC50 0.009Inhibition of human Vascular endothelial growth factor receptor 2 [AID241758, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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14
[SID103194628]
Kd 0.009Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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16
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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17
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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19
[SID103194628]
Kd 0.0098Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103194628]
Kd 0.011Binding constant for EGFR(L861Q) kinase domain [AID625005, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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21
[SID103194628]
Kd 0.011Binding constant for EGFR(L861Q) kinase domain [AID435907, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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22
[SID103194628]
Kd 0.011Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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23
[SID103194628]
Kd 0.011Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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24
[SID103194628]
Kd 0.012Binding constant for EGFR(S752-I759del) kinase domain [AID435792, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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25
[SID103194628]
Kd 0.012Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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26
[SID103194628]
Kd 0.012Binding constant for EGFR(S752-I759del) kinase domain [AID625006, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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27
[SID103194628]
Kd 0.012Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID625000, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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28
[SID103194628]
Kd 0.013Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID103194628]
Kd 0.014Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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30
[SID103194628]
Kd 0.014Binding constant for RET(M918T) kinase domain [AID435323, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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31
[SID103194628]
Kd 0.014Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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32
[SID103194628]
IC50 0.015Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells [AID257076, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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33
[SID103194628]
Kd 0.015Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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34
[SID103194628]
Kd 0.016Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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35
[SID103194628]
Kd 0.016Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID103194628]
IC50 0.016In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirus [AID69880, Type: Literature]
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37
[SID103194628]
IC50 0.017In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) [AID216649, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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38
[SID103194628]
Kd 0.017Average Binding Constant for EGFR ; NA=Not Active at 10 uM [AID256664, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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39
[SID103194628]
Kd 0.017Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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40
[SID103194628]
Kd 0.017Binding constant for LCK kinase domain [AID435676, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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41
[SID103194628]
Kd 0.018Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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42
[SID103194628]
Kd 0.02Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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43
[SID103194628]
IC50 0.022Inhibition of VEGFR2 phosphorylation in presence of 2 uM ATP by HTRF assay [AID263455, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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44
[SID103194628]
IC50 0.022Inhibition of VEGFR2 by enzymatic assay [AID262070, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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45
[SID103194628]
IC50 0.022Inhibitory activity against VEGFR2 by HTRF assay [AID259702, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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46
[SID103194628]
IC50 0.022Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assay [AID261930, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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47
[SID103194628]
IC50 0.022Inhibition of VEGFR1 by HTRF assay [AID305869, Type: Literature]
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48
[SID103194628]
IC50 0.025Inhibition of human endothelial cell growth stimulate by vascular endothelial growth factor [AID84824, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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49
[SID103194628]
IC50 0.025Inhibition of human endothelial cell growth stimulate by vascular endothelial growth factor [AID84824, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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50
[SID103194628]
IC50 0.025Inhibition of human endothelial cell growth stimulate by vascular endothelial growth factor [AID84824, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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