N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine (CID 3081361) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(470)
 
 
Inactive(249)
 
 
Inconclusive(22)
 
 
Unspecified(530)
 
 
Top Targets:
PKc(111)
 
 
 
 
PKc like(75)
 
 
 
 
STKc AGC(66)
 
 
 
 
PTKc Abl(41)
 
 
 
 
 
PTKc EGFR(39)
 
 
 
 
BioAssay Types:
Literature(1112)
 
 
 
 
 
Confirmatory(149)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(879)
 
 
 
 
IC50(73)
 
 
 
 
 
Potency(39)
 
 
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1028    Data Row: 1271   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID435935, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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2
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID435935, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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3
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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4
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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5
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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6
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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14
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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15
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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16
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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17
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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19
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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20
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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21
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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22
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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23
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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24
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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25
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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26
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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27
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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28
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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29
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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30
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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31
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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32
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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33
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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34
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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35
[SID103194628]
IC50 0.009Inhibition of human Vascular endothelial growth factor receptor 2 [AID241758, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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36
[SID103194628]
IC50 0.009Inhibition of human Vascular endothelial growth factor receptor 2 [AID241758, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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37
[SID103194628]
Kd 0.009Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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38
[SID103194628]
Kd 0.009Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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39
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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40
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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41
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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42
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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43
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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44
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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45
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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46
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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47
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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48
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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49
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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50
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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