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BioActivity Data for Compound N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine (CID 3081361)

BioActivity Outcomes:
Active(527)
 
 
Inactive(346)
 
 
Inconclusive(45)
 
 
Unspecified(558)
 
 
Top Targets:
PTKc Abl(45)
 
 
 
 
 
PTKc EGFR(43)
 
 
 
 
PTKc VEGFR2(31)
 
 
 
 
PTKc EphR A(25)
 
 
 
PTKc Kit(20)
 
 
 
BioAssay Types:
Literature(1151)
 
 
 
 
 
Confirmatory(253)
 
 
 
 
 
Summary(29)
 
 
 
Screening(10)
 
 
BioAssay Categories:
In vitro(466)
 
 
 
 
Biochemical(974)
 
 
 
 
 
Toxicity(14)
 
 
 
 
ADME(5)
 
 
Cell-based(50)
 
 
 
 
 
BioActivity Types:
Kd(882)
 
 
 
 
Potency(156)
 
 
 
 
IC50(93)
 
 
 
 
 
AC50(6)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1204    Data Row: 1476   Total Pages: 74   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID435935, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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2
[SID103194628]
Kd 0.0046Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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3
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103194628]
Kd 0.0048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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6
[SID103194628]
Kd 0.0059Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103194628]
Kd 0.0079Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103194628]
Kd 0.0087Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103194628]
Kd 0.0089Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103194628]
IC50 0.009Inhibition of human Vascular endothelial growth factor receptor 2 [AID241758, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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14
[SID103194628]
Kd 0.009Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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16
[SID103194628]
Kd 0.0095Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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17
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103194628]
Kd 0.0096Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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19
[SID103194628]
Kd 0.0098Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103194628]
Kd 0.011Binding constant for EGFR(L861Q) kinase domain [AID435907, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View