oxalylglycine (CID 3080614) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(25)
 
 
Unspecified(11)
 
 
Top Targets:
P4Hc(10)
 
 
Cupin 8(1)
 
 
BioAssay Types:
Literature(36)
 
 
 
BioActivity Types:
IC50(18)
 
 
 
Kd(4)
 
 
Ki(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 36    Data Row: 36   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103297835]
Ki 0.54Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160201, Type: Literature]
View
2
[SID103297835]
IC50 0.842Inhibition of PHD1 by HTRF assay [AID517384, Type: Literature]
View
3
[SID103297835]
IC50 2.1Inhibition of PHD1 [AID639778, Type: Literature]
View
4
[SID103297835]
IC50 2.1Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay [AID499338, Type: Literature]Egl nine homolog 2 [gi:32129513]
View
5
[SID103297835]
Kd 2.8Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature [AID446354, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
6
[SID103297835]
IC50 2.89Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160198, Type: Literature]
View
7
[SID103297835]
Kd 3.1Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
8
[SID103297835]
Kd 3.1Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
9
[SID103297835]
Kd 3.4Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature [AID446355, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
10
[SID103297835]
IC50 5.6Inhibition of human recombinant PHD2 expressed in Sf9 cells by time-resolved fluorescence assay [AID499339, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
11
[SID103297835]
IC50 6.2Inhibition of PHD2 [AID639776, Type: Literature]
View
12
[SID103297835]
Ki 8Inhibition of human recombinant PHD2 [AID344914, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
13
[SID103297835]
IC50 18.5Inhibition of human PHD2 at 293K temperature by solvent relaxation technique [AID446353, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
14
[SID103297835]
IC50 18.5Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
View
15
[SID103297835]
IC50 24Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay [AID344918, Type: Literature]
View
16
[SID103297835]
IC50 26Inhibition of human PHD2 catalytic domain (181-426) by FRET assay [AID440674, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
17
[SID103297835]
IC50 32Inhibition of Escherichia coli AlkB deltaN11 mutant using 5'-TTCmTTTTTTTTTTTT-3'-fluorescein as substrate after 4.5 mins by capillary electrophoresis-based laser-induced fluorescence assay [AID661346, Type: Literature]
View
18
[SID103297835]
 Binding affinity to Escherichia coli AlkB expressed in Escherichia coli BL21(DE3) at 15 uM for 30 mins by nondenaturing ESI-MS analysis [AID661344, Type: Literature]
View
19
[SID103297835]
IC50 Inhibition of human PHD2 [AID604084, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
20
[SID103297835]
 Inhibition of JMJD2D-mediated H3K9 demethylation activity at 3 mM [AID426464, Type: Literature]
View
21
[SID103297835]
 Inhibition of JMJD2D-mediated H3K9 demethylation activity at 1 mM [AID426465, Type: Literature]
View
22
[SID103297835]
 Inhibition of JMJD2C-mediated H3K9 demethylation activity at 3 mM [AID426466, Type: Literature]
View
23
[SID103297835]
 Inhibition of JMJD2A-mediated H3K9 demethylation activity at 3 mM [AID426467, Type: Literature]
View
24
[SID103297835]
 Inhibition of JMJD2A-mediated H3K9 demethylation activity at 1 mM [AID426472, Type: Literature]
View
25
[SID103297835]
 Inhibition of JMJD2C-mediated H3K9 demethylation activity at 1 mM [AID426473, Type: Literature]
View
26
[SID103297835]
IC50 78Inhibition of 2-oxoglutarate-dependent human JMJD2E in prescence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
View
27
[SID103297835]
IC50 250Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay [AID499337, Type: Literature]
View
28
[SID103297835]
IC50 250Inhibition of KDM4A [AID639772, Type: Literature]
View
29
[SID103297835]
IC50 500Inhibition of KDM4C [AID639774, Type: Literature]
View
30
[SID103297835]
IC50 500Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay [AID499336, Type: Literature]
View
31
[SID103297835]
IC50 830Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
View
32
[SID103297835]
Ki 1200Inhibition of asparaginyl hydroxylase factor-inhibiting-HIF [AID604083, Type: Literature]
View
33
[SID103297835]
Ki 1200Inhibition of human FIH [AID344915, Type: Literature]Hypoxia-inducible factor 1-alpha inhibitor [gi:32129605]
View
34
[SID103297835]
 Binding affinity to Escherichia coli AlkB deltaN11 mutant assessed as change in melting temperature at 200 uM by differential scanning fluorimetry [AID661345, Type: Literature]
View
35
[SID103297835]
 Selectivity ratio of IC50 for recombinant His-tagged JMJD2A to IC50 for recombinant His-tagged JMJD2C [AID499340, Type: Literature]
View
36
[SID103297835]
 Inhibition of human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) by TR-FRET assay [AID349747, Type: Literature]
View