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oxalylglycine (CID 3080614) - Compound BioActivity Data
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BioActivity Outcomes:
Active(41)
 
 
Unspecified(22)
 
 
Top Targets:
P4Hc(14)
 
 
 
zf-CXXC(2)
 
 
 
zf-HC5HC2H 2(2)
 
 
JmjC(2)
 
 
FTO NTD(1)
 
 
BioAssay Types:
Literature(63)
 
 
 
BioActivity Types:
IC50(33)
 
 
 
Kd(9)
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 56    Data Row: 63   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103297835]
Ki 0.54Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160201, Type: Literature]
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2
[SID103297835]
IC50 0.842Inhibition of PHD1 by HTRF assay [AID517384, Type: Literature]
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3
[SID103297835]
Kd 2Displacement of [13C]-2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coli [AID721520, Type: Literature]Egl nine homolog 1 [gi:32129514]
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4
[SID103297835]
IC50 2.1Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay [AID499338, Type: Literature]Egl nine homolog 2 [gi:32129513]
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5
[SID103297835]
IC50 2.1Inhibition of PHD1 [AID639778, Type: Literature]
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6
[SID103297835]
Kd 2.8Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature [AID446354, Type: Literature]Egl nine homolog 1 [gi:32129514]
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7
[SID103297835]
IC50 2.89Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160198, Type: Literature]
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8
[SID208012289]
Kd 3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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9
[SID208012289]
Kd 3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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10
[SID103297835]
Kd 3Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721525, Type: Literature]Egl nine homolog 1 [gi:32129514]
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11
[SID103297835]
Kd 3.1Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
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12
[SID103297835]
Kd 3.1Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
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13
[SID103297835]
Kd 3.4Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature [AID446355, Type: Literature]Egl nine homolog 1 [gi:32129514]
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14
[SID103297835]
Kd 4Binding affinity to human FIH catalytic domain Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721524, Type: Literature]
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15
[SID103297835]
IC50 5.6Inhibition of human recombinant PHD2 expressed in Sf9 cells by time-resolved fluorescence assay [AID499339, Type: Literature]Egl nine homolog 1 [gi:32129514]
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16
[SID103297835]
IC50 6.2Inhibition of PHD2 [AID639776, Type: Literature]
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17
[SID103297835]
Ki 8Inhibition of human recombinant PHD2 [AID344914, Type: Literature]Egl nine homolog 1 [gi:32129514]
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18
[SID103297835]
IC50 18.5Inhibition of human PHD2 at 293K temperature by solvent relaxation technique [AID446353, Type: Literature]Egl nine homolog 1 [gi:32129514]
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19
[SID103297835]
IC50 18.5Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
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20
[SID103297835]
IC50 20Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721523, Type: Literature]Egl nine homolog 1 [gi:32129514]
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