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oxalylglycine (CID 3080614) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Unspecified(15)
 
 
Top Targets:
P4Hc(14)
 
 
 
FTO NTD(1)
 
 
Cupin 8(1)
 
 
zf-CXXC(1)
 
 
BioAssay Types:
Literature(45)
 
 
 
BioActivity Types:
IC50(21)
 
 
 
Kd(7)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 45    Data Row: 45   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103297835]
Ki 0.54Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160201, Type: Literature]
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2
[SID103297835]
IC50 0.842Inhibition of PHD1 by HTRF assay [AID517384, Type: Literature]
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3
[SID103297835]
Kd 2Displacement of [13C]-2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coli [AID721520, Type: Literature]Egl nine homolog 1 [gi:32129514]
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4
[SID103297835]
IC50 2.1Inhibition of human recombinant PHD1 expressed in Sf9 cells by time-resolved fluorescence assay [AID499338, Type: Literature]Egl nine homolog 2 [gi:32129513]
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5
[SID103297835]
IC50 2.1Inhibition of PHD1 [AID639778, Type: Literature]
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6
[SID103297835]
Kd 2.8Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature [AID446354, Type: Literature]Egl nine homolog 1 [gi:32129514]
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7
[SID103297835]
IC50 2.89Compound was evaluated for the inhibition of prolyl 4-hydroxylase [AID160198, Type: Literature]
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8
[SID103297835]
Kd 3Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721525, Type: Literature]Egl nine homolog 1 [gi:32129514]
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9
[SID103297835]
Kd 3.1Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
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10
[SID103297835]
Kd 3.1Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
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11
[SID103297835]
Kd 3.4Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature [AID446355, Type: Literature]Egl nine homolog 1 [gi:32129514]
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12
[SID103297835]
Kd 4Binding affinity to human FIH catalytic domain Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721524, Type: Literature]
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13
[SID103297835]
IC50 5.6Inhibition of human recombinant PHD2 expressed in Sf9 cells by time-resolved fluorescence assay [AID499339, Type: Literature]Egl nine homolog 1 [gi:32129514]
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14
[SID103297835]
IC50 6.2Inhibition of PHD2 [AID639776, Type: Literature]
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15
[SID103297835]
Ki 8Inhibition of human recombinant PHD2 [AID344914, Type: Literature]Egl nine homolog 1 [gi:32129514]
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16
[SID103297835]
IC50 18.5Inhibition of human PHD2 at 293K temperature by solvent relaxation technique [AID446353, Type: Literature]Egl nine homolog 1 [gi:32129514]
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17
[SID103297835]
IC50 18.5Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
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18
[SID103297835]
IC50 20Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721523, Type: Literature]Egl nine homolog 1 [gi:32129514]
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19
[SID103297835]
IC50 24Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay [AID344918, Type: Literature]
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20
[SID103297835]
IC50 26Inhibition of human PHD2 catalytic domain (181-426) by FRET assay [AID440674, Type: Literature]Egl nine homolog 1 [gi:32129514]
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21
[SID103297835]
IC50 32Inhibition of Escherichia coli AlkB deltaN11 mutant using 5'-TTCmTTTTTTTTTTTT-3'-fluorescein as substrate after 4.5 mins by capillary electrophoresis-based laser-induced fluorescence assay [AID661346, Type: Literature]
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22
[SID103297835]
IC50 44Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis [AID734755, Type: Literature]Alpha-ketoglutarate-dependent dioxygenase FTO [gi:148841515]
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23
[SID103297835]
IC50 Inhibition of human PHD2 [AID604084, Type: Literature]Egl nine homolog 1 [gi:32129514]
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24
[SID103297835]
Inhibition of JMJD2D-mediated H3K9 demethylation activity at 3 mM [AID426464, Type: Literature]
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25
[SID103297835]
Inhibition of JMJD2D-mediated H3K9 demethylation activity at 1 mM [AID426465, Type: Literature]
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26
[SID103297835]
Inhibition of JMJD2C-mediated H3K9 demethylation activity at 3 mM [AID426466, Type: Literature]
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27
[SID103297835]
Inhibition of JMJD2A-mediated H3K9 demethylation activity at 3 mM [AID426467, Type: Literature]
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28
[SID103297835]
Inhibition of JMJD2A-mediated H3K9 demethylation activity at 1 mM [AID426472, Type: Literature]
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29
[SID103297835]
Inhibition of JMJD2C-mediated H3K9 demethylation activity at 1 mM [AID426473, Type: Literature]
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30
[SID103297835]
Binding affinity to Escherichia coli AlkB expressed in Escherichia coli BL21(DE3) at 15 uM for 30 mins by nondenaturing ESI-MS analysis [AID661344, Type: Literature]
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31
[SID103297835]
IC50 50Inhibition of human FIH catalytic domain Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721522, Type: Literature]
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32
[SID103297835]
IC50 78Inhibition of 2-oxoglutarate-dependent human JMJD2E in prescence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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33
[SID103297835]
IC50 250Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay [AID499337, Type: Literature]
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34
[SID103297835]
IC50 250Inhibition of KDM4A [AID639772, Type: Literature]
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35
[SID103297835]
IC50 500Inhibition of KDM4C [AID639774, Type: Literature]
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36
[SID103297835]
IC50 500Inhibition of recombinant His-tagged JMJD2C expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assay [AID499336, Type: Literature]
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37
[SID103297835]
IC50 830Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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38
[SID103297835]
Ki 1200Inhibition of asparaginyl hydroxylase factor-inhibiting-HIF [AID604083, Type: Literature]
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39
[SID103297835]
Ki 1200Inhibition of human FIH [AID344915, Type: Literature]Hypoxia-inducible factor 1-alpha inhibitor [gi:32129605]
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40
[SID103297835]
Displacement of 2OG from FBXL11 (1 to 517) (unknown origin) expressed in Escherichia coli at 800 uM [AID721519, Type: Literature]Lysine-specific demethylase 2A [gi:38257795]
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41
[SID103297835]
Selectivity ratio of IC50 for recombinant His-tagged JMJD2A to IC50 for recombinant His-tagged JMJD2C [AID499340, Type: Literature]
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42
[SID103297835]
Displacement of 2OG from FIH (unknown origin) expressed in Escherichia coli at 400 uM [AID721528, Type: Literature]
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43
[SID103297835]
Displacement of 2OG from catalytic domain of PHD2 (181 to 426) (unknown origin) expressed in Escherichia coli at 400 uM [AID721529, Type: Literature]Egl nine homolog 1 [gi:32129514]
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44
[SID103297835]
Inhibition of human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) by TR-FRET assay [AID349747, Type: Literature]
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45
[SID103297835]
Binding affinity to Escherichia coli AlkB deltaN11 mutant assessed as change in melting temperature at 200 uM by differential scanning fluorimetry [AID661345, Type: Literature]
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