3,3'-diindolylmethane (CID 3071) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(226)
 
 
Inconclusive(10)
 
 
Unspecified(29)
 
 
Top Targets:
Tubulin-bindi..(8)
 
 
 
NR LBD TR(8)
 
 
PLN02808(6)
 
 
HELICc(6)
 
 
pantethn trn(4)
 
 
BioAssay Types:
Confirmatory(205)
 
 
 
 
 
Literature(65)
 
 
 
 
Screening(16)
 
 
BioActivity Types:
Potency(138)
 
 
 
 
Kd(8)
 
 
 
IC50(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 202    Data Row: 289   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103525320]
Kd 0.0097Binding affinity to recombinant wild type Leishmania donovani AG83 topoisomerase 1b after 24 hrs by equilibrium dialysis method [AID582000, Type: Literature]
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2
[SID103525320]
Kd 0.05Binding affinity to Leishmania donovani small subunit of topoisomerase 1b [AID582007, Type: Literature]
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3
[SID103525320]
Kd 0.428Binding affinity to Leishmania donovani large subunit of topoisomerase 1b [AID582006, Type: Literature]
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4
[SID103525320]
IC50 1.25Antimicrobial activity against wild type Leishmania donovani AG83 assessed as inhibition of parasite growth after 24 hrs by MTT assay [AID581854, Type: Literature]
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5
[SID103525320]
IC50 5.5Antitumor activity against MCF7 cells [AID292177, Type: Literature]
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6
[SID26753758]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID103525320]
IC50 10Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay [AID660427, Type: Literature]
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8
[SID26753757]
Potency 15.8489Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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9
[SID26749354]
Potency 17.7828Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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10
[SID103525320]
Kd 24Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant and small subunit N184S mutant after 24 hrs by equilibrium dialysis method [AID582002, Type: Literature]
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11
[SID26753757]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID26753757]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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13
[SID26753757]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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14
[SID26753757]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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15
[SID103525320]
 Drug uptake in drug-resistant Leishmania donovani LdDR50 at 20 uM after 30 mins by spectrophotometric analysis [AID581977, Type: Literature]
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16
[SID103525320]
 Drug uptake in wild type Leishmania donovani AG83 at 20 uM after 30 mins by spectrophotometric analysis [AID581978, Type: Literature]
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17
[SID103525320]
 Antimicrobial activity against drug-resistant Leishmania donovani LdDR50 assessed as inhibition of parasite growth at up to 50 uM after 24 hrs by MTT assay [AID581853, Type: Literature]
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18
[SID103525320]
 Inhibition of recombinant Leishmania donovani AG83 topoisomerase 1b-mediated religation of 14-mer/25-mer suicide DNA substrate at 20 uM after 120 mins by PAGE analysis [AID581997, Type: Literature]
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19
[SID103525320]
 Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant-mediated religation of 14-mer/25-mer suicide DNA substrate at 20 uM after 120 mins by PAGE analysis [AID581998, Type: Literature]
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20
[SID103525320]
 Effect on recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit K430N mutant-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581993, Type: Literature]
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21
[SID103525320]
 Effect on recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581995, Type: Literature]
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22
[SID103525320]
 Inhibition of recombinant wild type Leishmania donovani AG83 topoisomerase 1b-mediated relaxation of supercoiled pBluescript SK(+) DNA at 10 uM after 30 mins using ethidium bromide staining [AID581983, Type: Literature]
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23
[SID103525320]
 Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant and small subunit N184S mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581984, Type: Literature]
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24
[SID103525320]
 Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b wild type small subunit and large subunit K430N mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581988, Type: Literature]
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25
[SID103525320]
 Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit K430N mutant and small subunit N184S mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581989, Type: Literature]
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26
[SID103525320]
 Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b wild type large subunit and small subunit N184S mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581990, Type: Literature]
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27
[SID103525320]
 Effect on recombinant wild type Leishmania donovani AG83 topoisomerase 1b-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581991, Type: Literature]
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28
[SID103525320]
IC50 50Growth inhibition of human MCF7 cells after 48 hrs by MTT assay [AID660428, Type: Literature]
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29
[SID103525320]
Kd 240Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b after 24 hrs by equilibrium dialysis method [AID581999, Type: Literature]
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30
[SID103525320]
Kd 380Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant after 24 hrs by equilibrium dialysis method [AID582005, Type: Literature]
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31
[SID103525320]
Kd 530Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L mutant after 24 hrs by equilibrium dialysis method [AID582004, Type: Literature]
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32
[SID103525320]
Kd 760Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant after 24 hrs by equilibrium dialysis method [AID582003, Type: Literature]
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33
[SID103525320]
IC50 36600Cytotoxicity against human WS1 cells for 48 hrs by MTT assay [AID436769, Type: Literature]
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34
[SID103525320]
IC50 37000Cytotoxicity against human ME18 cells for 48 hrs by MTT assay [AID436767, Type: Literature]
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35
[SID103525320]
IC50 40700Cytotoxicity against doxorubicin-resistant human ME18 cells for 48 hrs by MTT assay [AID436768, Type: Literature]
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36
[SID103525320]
 Ratio of antimicrobial activity against drug-resistant Leishmania donovani LdDR50 to antimicrobial activity against wild type Leishmania donovani AG83 [AID581852, Type: Literature]
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37
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 F270L, K430N mutant in large subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581856, Type: Literature]
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38
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 F270L, N184S mutant in large subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581855, Type: Literature]
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39
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 F270Lmutant in large subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581857, Type: Literature]
View
40
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 K430N mutant in large subunit and N184S mutant in small subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581979, Type: Literature]
View
41
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 K430N mutant in large subunit and wild type small subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581980, Type: Literature]
View
42
[SID103525320]
 Antimicrobial activity against wild type Leishmania donovani AG83 transfected with drug-resistant Leishmania donovani LdDR50 topoisomerase 1 wild type large subunit and N184S mutant in small subunit assessed as inhibition of parasite growth at 20 uM after 24 hrs by MTT assay [AID581981, Type: Literature]
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43
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as shoot length at 31.25 ppm on day 5 [AID308565, Type: Literature]
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44
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as root length at 31.25 ppm on day 5 [AID308566, Type: Literature]
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45
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as shoot length at 62.5 ppm on day 5 [AID308567, Type: Literature]
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46
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as root length at 62.5 ppm on day 5 [AID308568, Type: Literature]
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47
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as shoot length at 125 ppm on day 5 [AID308569, Type: Literature]
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48
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as root length at 125 ppm on day 5 [AID308570, Type: Literature]
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49
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as shoot length at 250 ppm on day 5 [AID308571, Type: Literature]
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50
[SID103525320]
 Growth promoting activity in Oryza sativa assessed as root length at 250 ppm on day 5 [AID308572, Type: Literature]
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