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3,3'-diindolylmethane (CID 3071) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(249)
 
 
Inconclusive(11)
 
 
Unspecified(44)
 
 
Top Targets:
NR LBD TR(8)
 
 
Tubulin-bindi..(8)
 
 
 
PLN02808(6)
 
 
HELICc(6)
 
 
PLDc mTdp1 2(6)
 
 
BioAssay Types:
Confirmatory(228)
 
 
 
 
 
Literature(69)
 
 
 
 
Screening(16)
 
 
BioActivity Types:
Potency(157)
 
 
 
 
Kd(8)
 
 
 
IC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 226    Data Row: 328   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103525320]
Kd 0.0097Binding affinity to recombinant wild type Leishmania donovani AG83 topoisomerase 1b after 24 hrs by equilibrium dialysis method [AID582000, Type: Literature]
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2
[SID103525320]
Kd 0.05Binding affinity to Leishmania donovani small subunit of topoisomerase 1b [AID582007, Type: Literature]
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3
[SID103525320]
Kd 0.428Binding affinity to Leishmania donovani large subunit of topoisomerase 1b [AID582006, Type: Literature]
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4
[SID103525320]
IC50 1.25Antimicrobial activity against wild type Leishmania donovani AG83 assessed as inhibition of parasite growth after 24 hrs by MTT assay [AID581854, Type: Literature]
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5
[SID103525320]
IC50 5.5Antitumor activity against MCF7 cells [AID292177, Type: Literature]
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6
[SID26753758]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID103525320]
IC50 10Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay [AID660427, Type: Literature]
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8
[SID26753757]
Potency 15.8489Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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9
[SID26749354]
Potency 17.7828Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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10
[SID103525320]
Kd 24Binding affinity to recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit F270L, K430N mutant and small subunit N184S mutant after 24 hrs by equilibrium dialysis method [AID582002, Type: Literature]
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11
[SID26753757]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID103525320]
Inhibition of recombinant Leishmania donovani AG83 topoisomerase 1b-mediated religation of 14-mer/25-mer suicide DNA substrate at 20 uM after 120 mins by PAGE analysis [AID581997, Type: Literature]
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13
[SID103525320]
Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant-mediated religation of 14-mer/25-mer suicide DNA substrate at 20 uM after 120 mins by PAGE analysis [AID581998, Type: Literature]
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14
[SID103525320]
Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b wild type small subunit and large subunit K430N mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581988, Type: Literature]
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15
[SID103525320]
Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit K430N mutant and small subunit N184S mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581989, Type: Literature]
View
16
[SID103525320]
Inhibition of recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b wild type large subunit and small subunit N184S mutant-mediated relaxation of supercoiled pBluescript SK(+) DNA at up to 50 uM after 30 mins using ethidium bromide staining [AID581990, Type: Literature]
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17
[SID103525320]
Effect on recombinant wild type Leishmania donovani AG83 topoisomerase 1b-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581991, Type: Literature]
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18
[SID103525320]
Effect on recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b large subunit K430N mutant-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581993, Type: Literature]
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19
[SID103525320]
Effect on recombinant drug-resistant Leishmania donovani LdDR50 topoisomerase 1b small subunit N184S mutant-mediated cleavage of 25-mer duplex oligonucleotide at 20 uM after 30 mins by PAGE analysis [AID581995, Type: Literature]
View
20
[SID103525320]
Antimicrobial activity against drug-resistant Leishmania donovani LdDR50 assessed as inhibition of parasite growth at up to 50 uM after 24 hrs by MTT assay [AID581853, Type: Literature]
View