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dasatinib (CID 3062316) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(815)
 
 
Inactive(333)
 
 
Inconclusive(97)
 
 
Unspecified(734)
 
 
Top Targets:
PKc(95)
 
 
 
 
PKc like(69)
 
 
 
 
PTKc Abl(37)
 
 
 
 
PTKc EGFR(34)
 
 
 
PTKc Src like(34)
 
 
 
BioAssay Types:
Literature(1291)
 
 
 
 
 
Confirmatory(246)
 
 
 
 
 
Screening(35)
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Kd(765)
 
 
 
IC50(538)
 
 
 
Potency(151)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1624    Data Row: 1979   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103501621]
IC50 1.09e-07SANGER: Inhibition of human BV-173 cell growth in a cell viability assay. [AID741988, Type: other]
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2
[SID103501621]
IC50 2.66e-07SANGER: Inhibition of human K-562 cell growth in a cell viability assay. [AID742260, Type: other]
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3
[SID103501621]
IC50 8.22e-07SANGER: Inhibition of human BL-70 cell growth in a cell viability assay. [AID741982, Type: other]
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4
[SID103501621]
IC50 1.08e-06SANGER: Inhibition of human EM-2 cell growth in a cell viability assay. [AID742144, Type: other]
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5
[SID103501621]
IC50 3.21e-06SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay. [AID742302, Type: other]
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6
[SID103501621]
IC50 9.8e-06SANGER: Inhibition of human MEG-01 cell growth in a cell viability assay. [AID742350, Type: other]
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7
[SID103501621]
IC50 1.31e-05SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: other]
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8
[SID103501621]
Kd 1.6e-05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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9
[SID103501621]
Kd 1.9e-05Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID103501621]
Kd 2.5e-05Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103501621]
Kd 2.9e-05Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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12
[SID103501621]
Kd 3.2e-05Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103501621]
Kd 3.7e-05Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID103501621]
Kd 3.9e-05Binding constant for EPHB6 kinase domain [AID624957, Type: Literature]Ephrin type-B receptor 6 [gi:294862532]
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15
[SID103501621]
IC50 4.04e-05SANGER: Inhibition of human CTV-1 cell growth in a cell viability assay. [AID742089, Type: other]
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16
[SID103501621]
Kd 4.1e-05Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
17
[SID103501621]
Kd 4.6e-05Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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18
[SID103501621]
Kd 4.6e-05Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
19
[SID103501621]
Kd 4.7e-05Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103501621]
Kd 5.8e-05Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
21
[SID103501621]
Kd 6.4e-05Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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22
[SID103501621]
IC50 7e-05Growth inhibition of human M07ep210 cells cells after 48 hrs by [3H]thymidine uptake assay [AID303308, Type: Literature]
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23
[SID103501621]
Kd 9.3e-05Binding constant for EPHA3 kinase domain [AID625009, Type: Literature]Ephrin type-A receptor 3 [gi:116241351]
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24
[SID103501621]
Kd 9.3e-05Binding constant for EPHA3 kinase domain [AID435794, Type: Literature]Ephrin type-A receptor 3 [gi:116241351]
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25
[SID103501621]
Kd 0.0001Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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26
[SID103501621]
IC50 0.00012Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl M244V mutant after 72 hrs by CCK-8 assay [AID709992, Type: Literature]
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27
[SID103501621]
IC50 0.00017Inhibition of human recombinant ABL1 Y253F mutant expressed in insect cells after 30 mins by FRET assay [AID724974, Type: Literature]
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28
[SID103501621]
Kd 0.00017Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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29
[SID103501621]
Kd 0.00017Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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30
[SID103501621]
IC50 0.0002Inhibition of Fyn [AID271967, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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31
[SID103501621]
Kd 0.0002Binding constant for LCK kinase domain [AID435676, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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32
[SID103501621]
Kd 0.0002Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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33
[SID103501621]
IC50 0.0002Cytotoxicity against mouse BA/F3 cells expressing BCR-ABL M351T mutant assessed as growth inhibition after 72 hrs by CCK-8 assay [AID724668, Type: Literature]
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34
[SID103501621]
IC50 0.00021Inhibition of human recombinant ABL1 E255K mutant expressed in insect cells after 30 mins by FRET assay [AID724979, Type: Literature]
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35
[SID103501621]
Kd 0.00021Binding constant for SRC kinase domain [AID435195, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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36
[SID103501621]
Kd 0.00021Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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37
[SID103501621]
Kd 0.00021Binding constant for BLK kinase domain [AID624841, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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38
[SID103501621]
Kd 0.00021Binding constant for BLK kinase domain [AID435646, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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39
[SID103501621]
IC50 0.00022Inhibition of human recombinant ABL1 M351T mutant expressed in insect cells after 30 mins by FRET assay [AID724975, Type: Literature]
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40
[SID103501621]
IC50 0.00024Inhibition of human recombinant ABL1 Q252H mutant expressed in insect cells after 30 mins by FRET assay [AID724978, Type: Literature]
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41
[SID103501621]
Kd 0.00024Binding constant for EPHA8 kinase domain [AID435287, Type: Literature]Ephrin type-A receptor 8 [gi:19857975]
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42
[SID103501621]
Kd 0.00024Binding constant for EPHA8 kinase domain [AID625120, Type: Literature]Ephrin type-A receptor 8 [gi:19857975]
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43
[SID103501621]
Kd 0.00024Binding constant for EPHA5 kinase domain [AID435158, Type: Literature]Ephrin type-A receptor 5 [gi:259016353]
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44
[SID103501621]
Kd 0.00024Binding constant for EPHA5 kinase domain [AID624737, Type: Literature]Ephrin type-A receptor 5 [gi:259016353]
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45
[SID103501621]
IC50 0.00025Inhibition of human recombinant ABL1 G250E mutant expressed in insect cells after 30 mins by FRET assay [AID724977, Type: Literature]
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46
[SID103501621]
IC50 0.00026Inhibition of BCR/ABL (unknown origin) using tyrosine 2 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET assay [AID732856, Type: Literature]
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47
[SID103501621]
IC50 0.00026Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assay [AID724981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID103501621]
IC50 0.0003Inhibition of human recombinant ABL1 H396P mutant expressed in insect cells after 30 mins by FRET assay [AID724976, Type: Literature]
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49
[SID103501621]
Kd 0.0003Binding constant for YES kinase domain [AID625018, Type: Literature]Tyrosine-protein kinase Yes [gi:125870]
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50
[SID103501621]
Kd 0.0003Binding constant for YES kinase domain [AID435328, Type: Literature]Tyrosine-protein kinase Yes [gi:125870]
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