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Diflunisal (CID 3059) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(752)
 
 
Inconclusive(98)
 
 
Unspecified(221)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(24)
 
 
 
p450(21)
 
 
 
 
alkPPc(14)
 
 
NR LBD PPAR(14)
 
 
 
 
BioAssay Types:
Confirmatory(363)
 
 
 
 
 
Screening(308)
 
 
 
 
Literature(167)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(289)
 
 
 
 
IC50(173)
 
 
 
 
 
EC50(12)
 
 
 
 
Ki(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 874    Data Row: 1097   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
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2
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID144204149]
Potency-Replicate_1 11.3588qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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7
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID170464956]
Potency-Replicate_1 13.3322qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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10
[SID855794]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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12
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID170464956]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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14
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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15
[SID855794]
HTS to identify Inhibitors of West Nile Virus NS2bNS3 Proteinase [AID577, Type: screening]unnamed protein product [West Nile virus] [gi:11528014]
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16
[SID103235071]
The first dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210956, Type: Literature]
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17
[SID103235071]
The second dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210957, Type: Literature]
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18
[SID48415892]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID855794]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors with Validation compound Set [AID588506, Type: screening]
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20
[SID855794]
HTS to identify compounds that promote myeloid differentiation with Validation compound set [AID588685, Type: screening] [geneid:3205]
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21
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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22
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 2 with KCC2 cells [AID1715, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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23
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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24
[SID103235071]
Inhibition of TNF-alpha-induced NF-kappaB activation in human HCT116 cells at 1 mM after 6 hrs by luciferase reporter gene assay [AID639952, Type: Literature]
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25
[SID855794]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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26
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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27
[SID103235071]
IC50 0.85TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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28
[SID103235071]
IC50 109Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes [AID624662, Type: Literature]
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29
[SID103235071]
IC50 122Inhibition of mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes [AID624661, Type: Literature]
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30
[SID103235071]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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31
[SID103235071]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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32
[SID103235071]
In vitro inhibitory activity against ovine cyclooxygenase-1 (COX-1) at 200 uM; Inactive [AID243647, Type: Literature]
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33
[SID103235071]
Antiinflammatory activity against BALB/c mouse assessed as inhibition of carrageenan-induced paw edema at 50 mg/kg, po after 4 hrs [AID295862, Type: Literature]
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34
[SID103235071]
Antinociceptive activity against mouse assessed as paw withdrawal latency at 50 mg/kg, po after 60 mins by hot plate test [AID295863, Type: Literature]
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35
[SID103235071]
Oral bioavailability in human [AID311524, Type: Literature]
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36
[SID103235071]
Apparent permeability across parallel artificial membrane [AID327169, Type: Literature]
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37
[SID103235071]
Hepatic clearance in human hepatocytes in absence of fetal calf serum [AID373867, Type: Literature]
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38
[SID103235071]
Antiinflammatory activity in mouse assessed as inhibition of xylene-induced ear edema at 40 mg/kg, po [AID396470, Type: Literature]
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39
[SID103235071]
Analgesic activity in Kunming mouse assessed as inhibition of acetic acid-induced writhing response at 40 mg/kg, po [AID396471, Type: Literature]
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40
[SID103235071]
Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema [AID396474, Type: Literature]
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41
[SID103235071]
Antiinflammatory activity against assessed as inhibition of carrageenan-induced foot paw edema in po dosed rat after 3 hrs [AID443729, Type: Literature]
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42
[SID11112675]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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43
[SID103235071]
Calculated membrane partition coefficient (Kmemb) [AID19006, Type: Literature]
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44
[SID103235071]
Delta logD (logD6.5 - logD7.4) [AID27167, Type: Literature]
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45
[SID103235071]
Partition coefficient (logD6.5) [AID28681, Type: other]
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46
[SID103235071]
Ionization constant (pKa) [AID29359, Type: other]
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47
[SID103235071]
Oral bioavailability in human [AID29811, Type: Literature]
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48
[SID103235071]
Beta-blocking activity was measured by applying the stepwise linear discriminate analysis; Active [AID41895, Type: other]
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49
[SID103235071]
Inhibition of beta-lactamase at 100 uM [AID43581, Type: Literature]
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50
[SID103235071]
Inhibition of chymotrypsin at 250 uM [AID52790, Type: Literature]
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