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Choline (CID 305) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(131)
 
 
Inconclusive(9)
 
 
Unspecified(54)
 
 
Top Targets:
MFS(36)
 
 
Neur chan LBD(10)
 
 
p450(9)
 
 
7TM GPCR Srx(6)
 
 
 
Pyr redox dim(4)
 
 
BioAssay Types:
Confirmatory(125)
 
 
 
Literature(82)
 
 
 
 
BioActivity Types:
Potency(104)
 
 
 
Ki(15)
 
 
Kd(9)
 
 
IC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 194    Data Row: 221   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103240245]
IC50 1.6In vitro ability to inhibit the transport of [3H]choline in to high affinity choline transport system HAChT [AID52130, Type: Literature]
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2
[SID170481258]
Kd 2.3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Abc-transporter Choline Binding Protein In Complex With Choline [gi:203282240]
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3
[SID170481258]
Kd 2.3Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Abc-transporter Choline Binding Protein In Complex With Choline [gi:203282240]
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4
[SID103240245]
Ki 18Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:2851491]
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5
[SID103240245]
Ki 18Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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6
[SID103240245]
Ki 21Binding affinity towards rat alpha2-beta4 nACh receptor expressed in HEK293 cells using [3H]EB as radioligand [AID225720, Type: Literature]
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7
[SID170483711]
Kd 28Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structures Of The Substrate-binding Protein Provide Insights Into The Multiple Compatible Solutes Binding Specificities Of Bacillus Subtilis Abc Transporter Opuc [gi:332639773]
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8
[SID170483711]
Kd 28Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Structures Of The Substrate-binding Protein Provide Insights Into The Multiple Compatible Solutes Binding Specificities Of Bacillus Subtilis Abc Transporter Opuc [gi:332639773]
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9
[SID170483933]
Kd 30.5Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Choline Binding Protein Opubc From Bacillus Subtilis [gi:340708458]
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10
[SID170483933]
Kd 30.5Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of Choline Binding Protein Opubc From Bacillus Subtilis [gi:340708458]
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11
[SID103240245]
Ki 34Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
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12
[SID103240245]
Ki 34Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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13
[SID103240245]
Ki 37Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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14
[SID103240245]
Ki 37Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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15
[SID103240245]
Ki 37Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
16
[SID103240245]
Ki 37Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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17
[SID103240245]
Ki 41Binding affinity to blood-brain barrier choline transporter in rat brain assessed as inhibition of [3H]choline uptake [AID344669, Type: Literature]
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18
[SID103240245]
Ki 41Binding affinity to blood-brain barrier choline transporter in rat brain assessed as inhibition of [3H]choline uptake [AID483710, Type: Literature]
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19
[SID103240245]
Ki 42Inhibition of [3H]-choline brain uptake was determined by in situ brain perfusion studies in male rats [AID52133, Type: Literature]
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20
[SID103240245]
Ki 42Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligand [AID145685, Type: Literature]
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