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Gestodene (CID 3033968) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(64)
 
 
Inconclusive(35)
 
 
Unspecified(13)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
 
p450(7)
 
 
 
 
NAD binding 8(4)
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
 
Literature(31)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(85)
 
 
 
 
IC50(16)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 126    Data Row: 126   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144205785]
Ratio Potency (uM) 0.000648625qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144205785]
Potency-Replicate_1 0.0133qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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3
[SID144205785]
Potency-Replicate_1 0.1679qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144205785]
Ratio Potency (uM) 0.169301qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144205785]
Potency-Replicate_1 0.19qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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6
[SID144205785]
Potency-Replicate_1 0.5354qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID144205785]
Ratio Potency (uM) 0.64799qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID144205785]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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9
[SID144205785]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144205785]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID144205785]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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12
[SID144205785]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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13
[SID144205785]
Potency-Replicate_1 26.6032qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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14
[SID144205785]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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15
[SID104239756]
Clinically relevant substrates of human liver microsomal P450 enzymes, isoform CYP3A4 [AID589039, Type: other]Cytochrome P450 3A4 [gi:116241312]
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16
[SID104239756]
Clinically relevant inhibitors of human liver microsomal P450 enzymes, isoform CYP3A4 [AID589048, Type: other]Cytochrome P450 3A4 [gi:116241312]
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17
[SID104239756]
Mechanism based inhibition of human cytochrome P450 3A4 [AID589108, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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18
[SID104239756]
Mechanism based inhibition of human cytochrome P450 3A4 [AID589109, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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19
[SID104239756]
Mechanism based inhibition of human cytochrome P450 3A4 measured by midazolam hydroxylation in vivo [AID589128, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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20
[SID104239756]
Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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