Bookmark and Share
fosfestrol (CID 3032325) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(149)
 
 
Inconclusive(4)
 
 
Unspecified(20)
 
 
Top Targets:
NR LBD ER(9)
 
 
 
NR LBD AR(7)
 
 
NR LBD GR(4)
 
 
Bromo ALL-1(3)
 
 
NR LBD TR(3)
 
 
BioAssay Types:
Literature(81)
 
 
 
Confirmatory(78)
 
 
 
 
Summary(15)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(90)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 114    Data Row: 178   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144206347]
Potency-Replicate_1 0.015qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
2
[SID144206347]
Potency-Replicate_1 0.0849qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
3
[SID144206347]
Ratio Potency (uM) 0.095112qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
4
[SID103770581]
Estrogen receptor agonist [AID742469, Type: other]Estrogen receptor [gi:544257]
View
5
[SID103770581]
Estrogen receptor agonist [AID742469, Type: other]Estrogen receptor beta [gi:6166154]
View
6
[SID103770581]
Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] [AID1079931, Type: Literature]
View
7
[SID103770581]
Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] [AID1079932, Type: Literature]
View
8
[SID103770581]
Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is number of references indexed. [column 'AIGUE' in source] [AID1079933, Type: Literature]
View
9
[SID103770581]
Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] [AID1079934, Type: Literature]
View
10
[SID103770581]
Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] [AID1079935, Type: Literature]
View
11
[SID103770581]
Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] [AID1079936, Type: Literature]
View
12
[SID103770581]
Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] [AID1079937, Type: Literature]
View
13
[SID103770581]
Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] [AID1079938, Type: Literature]
View
14
[SID103770581]
Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] [AID1079939, Type: Literature]
View
15
[SID103770581]
Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] [AID1079940, Type: Literature]
View
16
[SID103770581]
Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] [AID1079941, Type: Literature]
View
17
[SID103770581]
Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] [AID1079942, Type: Literature]
View
18
[SID103770581]
Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] [AID1079943, Type: Literature]
View
19
[SID103770581]
Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] [AID1079944, Type: Literature]
View
20
[SID103770581]
Animal toxicity known. [column 'TOXIC' in source] [AID1079945, Type: Literature]
View