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BioActivity Data for Compound 173374-91-9 (CID 3025920)

BioActivity Outcomes:
Active(6)
 
 
Inactive(199)
 
 
Inconclusive(3)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(17)
 
 
NACHT(7)
 
 
 
 
RasGEF(4)
 
 
 
ZnMc TACE lik..(4)
 
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(151)
 
 
 
Confirmatory(44)
 
 
 
 
Literature(13)
 
 
 
 
BioAssay Categories:
Biochemical(52)
 
 
 
 
Toxicity(3)
 
 
 
ADME(1)
 
 
Cell-based(59)
 
 
 
 
Organism-base..(5)
 
 
BioActivity Types:
Potency(35)
 
 
 
IC50(12)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 197    Data Row: 211   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160666492]
IC50 2.2Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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2
[SID85248361]
IC50_Mean 2.22SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID85248361]
IC50_Mean 2.41SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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4
[SID85248361]
IC50 5.247SAR analysis of NF-kB dependent luciferase using DAP as an inducer [AID2264, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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5
[SID99495606]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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6
[SID99495606]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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7
[SID160666492]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
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8
[SID160666492]
IC50 20Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
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9
[SID160666492]
Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
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10
[SID85248361]
IC50_Mean 5SAR analysis of muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells. [AID2260, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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11
[SID85248361]
IC50_Mean 5SAR analysis of tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells. [AID2245, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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12
[SID85248361]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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13
[SID85248361]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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14
[SID85248361]
IC50 25SAR analysis of NF-kB dependent luciferase using PMA/Ionomycin as an inducer [AID2261, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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15
[SID85248361]
IC50 25SAR analysis of NF-kB dependent luciferase using Doxorucibin as an inducer [AID2255, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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16
[SID99495606]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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17
[SID99495606]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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18
[SID99495606]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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19
[SID99495606]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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20
[SID99495606]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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